Premature ovarian failure and androgen receptor gene CAG repeat lengths weighted by X chromosome inactivation patterns
Received 12 September 2007; received in revised form 28 November 2007; accepted 28 November 2007. published online 18 February 2008.
The CAG repeat lengths weighted by X-inactivation ratios were significantly shorter in 58 Japanese patients with premature ovarian failure (POF) than in 42 age-matched control females with normal menses. The results suggest that short CAG repeats with a relatively high androgen receptor function may constitute a susceptibility factor for the development of POF.
aDepartment of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan
bBiomedical Science PhD Program, Tokyo Medical and Dental University, Tokyo, Japan
cDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan
dDepartment of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kawasaki, Japan
Reprint requests: Tsutomu Ogata, M.D., Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan (FAX: 81-3-5494-7026).
This study was supported by Grants for Child Health and Development (17C-2) and for Research on Children and Families (H18-005) from the Ministry of Health, Labor, and Welfare, and by Grants-in-Aid for Scientific Research (priority areas: 16086215; category B: 19390290) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.
ABSTRACT