Premature ovarian failure and androgen receptor gene CAG repeat lengths weighted by X chromosome inactivation patterns
The CAG repeat lengths weighted by X-inactivation ratios were significantly shorter in 58 Japanese patients with premature ovarian failure (POF) than in 42 age-matched control females with normal menses. The results suggest that short CAG repeats with a relatively high androgen receptor function may constitute a susceptibility factor for the development of POF.
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This study was supported by Grants for Child Health and Development (17C-2) and for Research on Children and Families (H18-005) from the Ministry of Health, Labor, and Welfare, and by Grants-in-Aid for Scientific Research (priority areas: 16086215; category B: 19390290) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.
PII: S0015-0282(07)04152-0
doi:10.1016/j.fertnstert.2007.11.085
© 2009 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

