Fertility and Sterility
Volume 91, Issue 2 , Pages 649-652, February 2009

Premature ovarian failure and androgen receptor gene CAG repeat lengths weighted by X chromosome inactivation patterns

  • Fumihiro Sugawa, B.Sc.

      Affiliations

    • Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan
    • Biomedical Science PhD Program, Tokyo Medical and Dental University, Tokyo, Japan
    • ,
  • Yuka Wada, M.D.

      Affiliations

    • Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan
    • ,
  • Tetsuo Maruyama, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan
    • ,
  • Hiroshi Uchida, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan
    • ,
  • Bunpei Ishizuka, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kawasaki, Japan
    • ,
  • Tsutomu Ogata, M.D.

      Affiliations

    • Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan
    • Biomedical Science PhD Program, Tokyo Medical and Dental University, Tokyo, Japan
    • Corresponding Author InformationReprint requests: Tsutomu Ogata, M.D., Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan (FAX: 81-3-5494-7026).

Received 12 September 2007; received in revised form 28 November 2007; accepted 28 November 2007. published online 18 February 2008.

The CAG repeat lengths weighted by X-inactivation ratios were significantly shorter in 58 Japanese patients with premature ovarian failure (POF) than in 42 age-matched control females with normal menses. The results suggest that short CAG repeats with a relatively high androgen receptor function may constitute a susceptibility factor for the development of POF.

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 This study was supported by Grants for Child Health and Development (17C-2) and for Research on Children and Families (H18-005) from the Ministry of Health, Labor, and Welfare, and by Grants-in-Aid for Scientific Research (priority areas: 16086215; category B: 19390290) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.

PII: S0015-0282(07)04152-0

doi:10.1016/j.fertnstert.2007.11.085

Fertility and Sterility
Volume 91, Issue 2 , Pages 649-652, February 2009

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