Fertility and Sterility
Volume 91, Issue 2 , Pages 649-652 , February 2009

Premature ovarian failure and androgen receptor gene CAG repeat lengths weighted by X chromosome inactivation patterns

  • Fumihiro Sugawa, B.Sc.

      Affiliations

    • Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan
    • Biomedical Science PhD Program, Tokyo Medical and Dental University, Tokyo, Japan
    • ,
  • Yuka Wada, M.D.

      Affiliations

    • Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan
    • ,
  • Tetsuo Maruyama, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan
    • ,
  • Hiroshi Uchida, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan
    • ,
  • Bunpei Ishizuka, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kawasaki, Japan
    • ,
  • Tsutomu Ogata, M.D.

      Affiliations

    • Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan
    • Biomedical Science PhD Program, Tokyo Medical and Dental University, Tokyo, Japan
    • Corresponding Author InformationReprint requests: Tsutomu Ogata, M.D., Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan (FAX: 81-3-5494-7026).

Received 12 September 2007 ,Revised 28 November 2007 ,Accepted 28 November 2007.

References 

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  11. Calvo RM, Asuncion M, Sancho J, San Millan JL, Escobar-Morreale HF. The role of the CAG repeat polymorphism in the androgen receptor gene and of skewed X-chromosome inactivation, in the pathogenesis of hirsutism. J Clin Endocrinol Metab. 2000;85:1735–1740
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  15. Allen RC, Zoghbi HY, Moseley AB, Rosenblatt HM, Belmont JW. Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation. Am J Hum Genet. 1992;51:1229–1239
  16. Tetsuka M, Whitelaw PF, Bremner WJ, Millar MR, Smyth CD, Hillier SG. Developmental regulation of androgen receptor in rat ovary. J Endocrinol. 1995;145:535–543
  17. Bachelot A, Plu-Bureau G, Thibaud E, Laborde K, Pinto G, Samara D, et al. Long-term outcome of patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Horm Res. 2006;67:268–276
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  19. Sharp A, Robinson D, Jacobs P. Age- and tissue-specific variation of X chromosome inactivation ratios in normal women. Hum Genet. 2000;107:343–349
  20. Shiina H, Matsumoto T, Sato T, Igarashi K, Miyamoto J, Takemasa S, et al. Premature ovarian failure in androgen receptor-deficient mice. Proc Natl Acad Sci U S A. 2005;103:224–229

 This study was supported by Grants for Child Health and Development (17C-2) and for Research on Children and Families (H18-005) from the Ministry of Health, Labor, and Welfare, and by Grants-in-Aid for Scientific Research (priority areas: 16086215; category B: 19390290) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.

PII: S0015-0282(07)04152-0

doi: 10.1016/j.fertnstert.2007.11.085

Fertility and Sterility
Volume 91, Issue 2 , Pages 649-652 , February 2009

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