The role of antimullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count

Broer, Simone L.; Mol, Ben Willem J.; Hendriks, Dave; Broekmans, Frank J.M.

doi:10.1016/j.fertnstert.2007.12.013

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Volume 91, Issue 3 , Pages 705-714, March 2009

The role of antimullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count

Simone L. Broer, B.Sc.
- Department of Reproductive Medicine, Division of Obstetrics, Neonatology, and Gynecology, University Medical Center, Utrecht, The Netherlands
Ben Willem J. Mol, M.D., Ph.D.
- Department of Obstetrics and Gynecology, Academic Medical Center, Amsterdam, The Netherlands
Dave Hendriks, M.D., Ph.D.
- Department of Reproductive Medicine, Division of Obstetrics, Neonatology, and Gynecology, University Medical Center, Utrecht, The Netherlands
Frank J.M. Broekmans, M.D., Ph.D.
- Department of Reproductive Medicine, Division of Obstetrics, Neonatology, and Gynecology, University Medical Center, Utrecht, The Netherlands
- Reprint requests: F. Broekmans, M.D., Department of Reproductive Medicine, Division of Obstetrics, Neonatology, and Gynecology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands (FAX: 31-30-2505433).

Received 19 July 2007; received in revised form 5 December 2007; accepted 5 December 2007. published online 05 March 2008.

Objective

To assess the value of antimullerian hormone (AMH) as a test to predict poor ovarian response and pregnancy occurrence after IVF and to compare it with the performance of the antral follicle count (AFC).

Design

A systematic review of existing literature and a meta-analysis were carried out. After a comprehensive search, studies were included if 2 × 2 tables for outcomes poor response and pregnancy in IVF patients in relation to AMH or AFC could be constructed.

Setting

Academic referral center for tertiary care.

Patient(s)

Cases indicated for IVF.

Intervention(s)

None.

Main Outcome Measure(s)

Poor response and nonpregnancy after IVF.

Result(s)

A total of 13 studies were found reporting on AMH and 17 on AFC. Because of heterogeneity among studies, calculation of a summary point estimate for sensitivity and specificity was not possible. However, for both tests summary receiver operating characteristic curves for the outcome measures poor response and nonpregnancy could be estimated and compared. The curves for the prediction of poor response indicated no significant difference between the performances of AMH and AFC. For the prediction of nonpregnancy, poor performance for both AMH and AFC was found.

Conclusion(s)

In this meta-analysis it was shown that AMH has at least the same level of accuracy and clinical value for the prediction of poor response and nonpregnancy as AFC.

Key Words: Antimullerian hormone, antral follicle count, IVF, poor response, pregnancy, meta-analysis