Fertility and Sterility
Volume 91, Issue 3 , Pages 884-892 , March 2009

Recanalization and particle exclusion after embolization of uterine arteries in sheep: a long-term study

  • Alexandre Laurent, M.D., Ph.D.

      Affiliations

    • Department of Interventional Neuroradiology, AP-HP, Lariboisière Hospital, Paris, France
    • Center for Research of Interventional Imaging (CR2i), AP-HP, INRA, Paris, France
    • Corresponding Author InformationReprint requests: Alexandre Laurent, M.D., Ph.D., APHP - Hopital Lariboisiere, Department of Interventional Neuroradiology, 3 rue A. Pare, F-75010 Paris, France (FAX: 33-1-49-95-83-56).
    • ,
  • Michel Wassef, M.D.

      Affiliations

    • Department of Pathology, AP-HP, Lariboisière Hospital, Paris, France
    • ,
  • Julien Namur, Ph.D.

      Affiliations

    • Department of Pathology, AP-HP, Lariboisière Hospital, Paris, France
    • ,
  • Jacques Martal, Vet. D. Ph.D.

      Affiliations

    • Unit of Physiology of Reproduction, INRA, Paris, France
    • ,
  • Denis Labarre, Ph.D.

      Affiliations

    • Biomaterials and Polymers, CNRS UMR 8612, Paris, France
    • ,
  • Jean-Pierre Pelage, M.D., Ph.D.

      Affiliations

    • Department of Radiology and Interventional Imaging, AP-HP, Ambroise Paré Hospital, Paris, France

Received 20 August 2007 ,Revised 5 December 2007 ,Accepted 5 December 2007.

References 

  1. Tomashefski JF, Cohen AM, Doershuk CF. Longterm histopathologic follow-up of bronchial arteries after therapeutic embolization with polyvinyl alcohol (Ivalon) in patients with cystic fibrosis. Hum Pathol. 1988;19:555–561
  2. Griendling KK, Fuller EO, Cox RH. Pregnancy-induced changes in sheep uterine and carotid arteries. Am J Physiol. 1985;248:H658–H665
  3. Ford SP. Control of uterine and ovarian blood flow throughout the estrous cycle and pregnancy of ewes, sows and cows. J Anim Sci. 1982;55(Suppl 2):32–42
  4. Palmer SK, Zamudio S, Coffin C, Parker S, Stamm E, Moore LG. Quantitative estimation of human uterine artery blood flow and pelvic blood flow redistribution in pregnancy. Obstet Gynecol. 1992;80:1000–1006
  5. Fuller EO, Galletti PM, Takeuchi T. Major and collateral components of blood flow to pregnant sheep uterus. Am J Physiol. 1975;229:279–285
  6. Lang U, Baker RS, Braems G, Zygmunt M, Kunzel W, Clark KE. Uterine blood flow—a determinant of fetal growth. Eur J Obstet Gynecol Reprod Biol. 2003;110(Suppl 1):S55–S61
  7. Casele HL, Laifer SA. Successful pregnancy after bilateral hypogastric artery ligation. A case report. J Reprod Med. 1997;42:306–308
  8. Nizard J, Barrinque L, Frydman R, Fernandez H. Fertility and pregnancy outcomes following hypogastric artery ligation for severe post-partum haemorrhage. Hum Reprod. 2003;18:844–848
  9. Cordonnier C, Ha-Vien DE, Depret S, Houfflin-Debarge V, Provost N, Subtil D. Foetal growth restriction in the next pregnancy after uterine artery embolisation for post-partum haemorrhage. Eur J Obstet Gynecol Reprod Biol. 2002;103:183–184
  10. Kim MD, Kim NK, Kim HJ, Lee MH. Pregnancy following uterine artery embolization with polyvinyl alcohol particles for patients with uterine fibroid or adenomyosis. Cardiovasc Intervent Radiol. 2005;28:611–615
  11. Goldberg J, Pereira L, Berghella V. Pregnancy after uterine artery embolization. Obstet Gynecol. 2002;100:869–872
  12. Pron G, Mocarski E, Bennett J, Vilos G, Common A, Vanderburgh L. Pregnancy after uterine artery embolization for leiomyomata: the Ontario multicenter trial. Obstet Gynecol. 2005;105:67–76
  13. Spies JB, Allison S, Flick P, McCullough M, Sterbis K, Cramp M, et al. Polyvinyl alcohol particles and tris-acryl gelatin microspheres for uterine artery embolization for leiomyomas: results of a randomized comparative study. J Vasc Interv Radiol. 2004;15:793–800
  14. Siskin GP, Englander M, Stainken BF, Ahn J, Dowling K, Dolen EG. Embolic agents used for uterine fibroid embolization. AJR Am J Roentgenol. 2000;175:767–773
  15. Laurent A, Pelage JP, Wassef M, Martal J. Fertility after bilateral uterine artery embolization in sheep model. Fertil Steril. Published online May 24, 2007.
  16. Pelage JP, Laurent A, Wassef M, Bonneau M, Germain D, Rymer R, et al. Uterine artery embolization in sheep: comparison of acute effects with polyvinyl alcohol particles and calibrated microspheres. Radiology. 2002;224:436–445
  17. Chua GC, Wilsher M, Young MPA, Manyonda I, Morgan R, Belli AM. Comparison of particle penetration with non spherical polyvinyl alcohol versus trisacryl gelatin microspheres in women undergoing premyomectomy uterine artery embolization. Clin Radiol. 2000;60:116–122
  18. Andrews RT, Binkert CA. Relative rates of blood flow reduction during transcatheter arterial embolization with tris-acryl gelatin microspheres or polyvinyl alcohol: quantitative comparison in a swine model. J Vasc Interv Radiol. 2003;14:1311–1316
  19. Colgan TJ, Pron G, Mocarski EJ, Bennett JD, Asch MR, Common A. Pathologic features of uteri and leiomyomas following uterine artery embolization for leiomyomas. Am J Surg Pathol. 2003;27:167–177
  20. Laurent A, Wassef M, Chapot R, Houdart E, Merland JJ. Location of vessel occlusion of calibrated tris-acryl gelatin microspheres for tumor and arteriovenous malformation embolization. J Vasc Interv Radiol. 2004;15:491–496
  21. Pelage JP, Laurent A, Bonneau M, Wassef M, Rymer R, Merland JJ. Arterial blood supply to the uterus in nonpregnant sheep: a pertinent model for clinical practice?. Invest Radiol. 2001;36:721–725
  22. McCluggage WG, Ellis PK, McClure N, Walker WJ, Jackson PA, Manek S. Pathologic features of uterine leiomyomas following uterine artery embolization. Int J Gynecol Pathol. 2000;19:342–347
  23. Biondi A, Merland JJ, Reizine D, Aymard A, Hodes JE, Lecoz P, et al. Embolization with particles in thoracic intramedullary arteriovenous malformations: long-term angiographic and clinical results. Radiology. 1990;177:651–658
  24. Hall WA, Oldfield EH, Doppman JL. Recanalization of spinal arteriovenous malformations following embolization. J Neurosurg. 1989;70:714–720
  25. Chiesa AG, Hart WR. Uterine artery embolization of leiomyomas with trisacryl gelatin microspheres (TGM): pathologic features and comparison with polyvinyl alcohol emboli. Int J Gynecol Pathol. 2004;23:386–392
  26. Cornelis F, Ferrand J, Le Chapelain Y, Ciraru-Vigneron N, Ravina JH. Morphological features of embolised myomata. Minim Invasive Ther Allied Technol. 1999;8:437–439
  27. Chaouat G, Menu E. Immunology of pregnancy. In:  Thibault C,  Levasseur MC,  Hunter RHF editor. Reproduction in mammals and man. Paris: Ellipses; 2001;p. 461–474
  28. Martal J, Chene N, Camous S, Huynh L, Lantier F, Hermier P, et al. Recent developments and potentialities for reducing embryo mortality in ruminants: the role of IFN-tau and other cytokines in early pregnancy. Reprod Fertil Dev. 1997;9:355–380
  29. Stewart CL, Kaspar P, Brunet LJ, Bhatt H, Gadi I, Kontgen F, et al. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature. 1992;359:76–79
  30. Laurent A, Wassef M, Pelage JP, Velzenberger E, Namur J, Schwartz-Cornil I, Martal J, Merland JJ. Quantification of inflammatory reaction towards Embosphere and Contour SE microspheres after embolization in uterine sheep. Presented at: CIRSE 2004, September 25–29, 2004. Cardiovascular and Interventional Radiological Society of Europe, Vienna, Austria.
  31. Castaneda-Zuniga WR, Sanchez R, Amplatz K. Experimental observations on short and long-term effects of arterial occlusion with Ivalon. Radiology. 1978;126:783–785
  32. Davidson GS, Terbrugge KG. Histologic long-term follow-up after embolization with polyvinyl alcohol particles. AJNR Am J Neuroradiol. 1995;16:843–846
  33. White RI, Strandberg JV, Gross GS, Barth KH. Therapeutic embolization with long-term occluding agents and their effects on embolized tissues. Radiology. 1977;125:677–687

 A.L. and M.W. contributed equally to the work, and therefore should both be considered first authors.

 A.L. and M.W. are the inventors of TGMS, the patent of which assignee is Assistance Publique Hôpitaux de Paris (APHP). J.N. has nothing to disclose. J.M. has nothing to disclose. D.L. has nothing to disclose. J.-P.P. has nothing to disclose.

 Presented at the Cardiovascular and Interventional Society of Europe (CIRSE), Antalya, Turkey, September 20–24, 2003.

PII: S0015-0282(07)04197-0

doi: 10.1016/j.fertnstert.2007.12.015

Fertility and Sterility
Volume 91, Issue 3 , Pages 884-892 , March 2009

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