Poor sperm quality affects clinical outcomes of intracytoplasmic sperm injection in fresh and subsequent frozen–thawed cycles: potential paternal effects on pregnancy outcomes

Lee, Sun-Hee; Song, Haengseok; Park, Yong-Seog; Koong, Mi Kyoung; Song, In Ok; Jun, Jin Hyun

doi:10.1016/j.fertnstert.2007.12.061

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Volume 91, Issue 3 , Pages 798-804, March 2009

Poor sperm quality affects clinical outcomes of intracytoplasmic sperm injection in fresh and subsequent frozen–thawed cycles: potential paternal effects on pregnancy outcomes

Sun-Hee Lee, M.Sc.
- Laboratory of Reproductive Biology and Infertility, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, South Korea
Haengseok Song, Ph.D.
- Laboratory of Reproductive Biology and Infertility, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, South Korea
- Department of Medicine, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, South Korea
Yong-Seog Park, Ph.D.
- Laboratory of Reproductive Biology and Infertility, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, South Korea
- Department of Medicine, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, South Korea
Mi Kyoung Koong, M.D., Ph.D.
- Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, South Korea
In Ok Song, M.D., Ph.D.
- Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, South Korea
Jin Hyun Jun, Ph.D.
- Laboratory of Reproductive Biology and Infertility, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, South Korea
- Department of Medicine, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, South Korea
- Reprint requests: Jin Hyun Jun, Ph.D., Laboratory of Reproductive Biology and Infertility, Cheil General Hospital and Women's Healthcare Center, 1-19 Mukjeong-dong, Jung-gu, Seoul 100-380, South Korea (FAX: 82-2-2265-5621).

Received 17 September 2007; received in revised form 19 December 2007; accepted 19 December 2007. published online 25 June 2008.

Objective

To evaluate objectively whether poor sperm quality affects sequential events from fertilization to delivery in fresh intracytoplasmic sperm injection (ICSI) and subsequent frozen–thawed embryo transfer (ET) cycles.

Design

Retrospective study.

Setting

University-based centers for reproductive medicine.

Patient(s)

For unbiased comparison, 206 cycles were chosen from 1,999 cycles of patients who underwent ICSI-ET and/or subsequent frozen–thawed ET. Cycles met the following criteria: day 3 ET; female age, <40 y; number of retrieved oocytes, ≥5; no split insemination; and no female factors but tubal factor.

Intervention(s)

None.

Main Outcome Measure(s)

The rates of fertilization, embryo implantation, clinical pregnancy, and delivery and sequential embryonic score (SES) were compared between normal-spermatogenesis patients (NSPs) and defective-spermatogenesis patients (DSPs).

Result(s)

Although sum SES, mean SES, and top SES of transferred embryos on day 3 were similar between NSPs and DSPs, the rates of implantation, clinical pregnancy, and delivery of NSPs were significantly higher than those of DSPs. Furthermore, subsequent ET cycles with frozen–thawed embryos in NSPs and DSPs who failed to achieve pregnancy in their fresh cycles showed that rates of implantation and clinical pregnancy also were significantly lower in DSPs.