Fertility and Sterility
Volume 91, Issue 3 , Pages 675-681 , March 2009

Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis—a randomized, double-blind, multicenter, controlled trial

  • Tasuku Harada, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan
    • Corresponding Author InformationReprint requests: Tasuku Harada, M.D., Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago 683-8504, Japan (FAX: +81-859-38-6649).
    • ,
  • Mikio Momoeda, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    • ,
  • Yuji Taketani, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    • ,
  • Takeshi Aso, M.D.

      Affiliations

    • Department of Comprehensive Reproductive Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    • ,
  • Masao Fukunaga, M.D.

      Affiliations

    • Department of Nuclear Medicine, Kawasaki Medical School, Kurashiki, Japan
    • ,
  • Hiroshi Hagino, M.D.

      Affiliations

    • Rehabilitation Division, Tottori University School of Medicine, Yonago, Japan
    • ,
  • Naoki Terakawa, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan

Received 4 December 2007 ,Revised 31 December 2007 ,Accepted 31 December 2007.

References 

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  3. Momoeda M, Taketani Y, Terakawa N, Hoshiai H, Tanaka K, Tsutsumi O, et al. Is endometriosis really associated with pain?. Gynecol Obstet Invest. 2002;54(Suppl 1):18–23
  4. Olive DL, Pritts EA. Treatment of endometriosis. N Engl J Med. 2001;345:266–275
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  9. Horie S, Harada T, Mitsunari M, Taniguchi F, Iwabe T, Terakawa N. Progesterone and progestational compounds attenuate tumor necrosis factor alpha-induced interleukin-8 production via nuclear factor kappa B inactivation in endometriotic stromal cells. Fertil Steril. 2005;83:1530–1535
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  17. Dallenbach-Hellweg G. The influence of contraceptive steroids on the histological appearance of the endometrium. In:  Diczfalusy E,  Fraser IS,  Webb FTG editor. Endometrial bleeding and steroidal contraception. Bath, England: Pitman Press; 1980;p. 153–173
  18. Fraser IS. Bleeding arising from the use of exogenous steroids. Baillieres Best Pract Res Clin Obstet Gynaecol. 1999;13:203–222
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 Dienogest and intranasal buserelin acetate were supplied by Mochida Pharmaceutical Co., Ltd, Tokyo, Japan.

 This study was sponsored by Mochida Pharmaceutical Co., Ltd.

 Tasuku Harada, Mikio Momoeda, Yuji Taketani, Takeshi Aso, Masao Fukunaga, Hiroshi Hagino and Naoki Terakawa have received consulting fees from Mochida Pharmaceutical Co., LTD.

PII: S0015-0282(08)00007-1

doi: 10.1016/j.fertnstert.2007.12.080

Fertility and Sterility
Volume 91, Issue 3 , Pages 675-681 , March 2009

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