Weight change and ovarian steroid profiles in young women
Received 15 November 2007; received in revised form 31 December 2007; accepted 31 December 2007. published online 04 March 2008.
Objective
To investigate possible short-term effects of voluntary weight loss on ovarian steroid profiles in young women, in light of better established long-term effects in older women.
Design
We tested for an association of voluntary weight change over the course of a menstrual cycle with salivary E2 and P profiles in the same menstrual cycle.
Setting
Students were recruited in a college residence hall, and they provided daily saliva samples to a researcher living nearby.
Patient(s)
The 65 women who participated were all college students and ranged in age between 18 and 23 years.
Intervention(s)
None.
Main Outcome Measure(s)
Weight was assessed in the first week of the menstrual cycle and first week of the following menstrual cycle. Estradiol and P were measured by radioimmunoassay in daily saliva samples.
Result(s)
We did not detect a suppressive effect of weight loss on the overall level of either hormone. However, we did find evidence for more distinct follicular and luteal E2 peaks in women who gained weight. Peak luteal P also arrived about 2 days earlier in women who gained weight.
Conclusion(s)
This finding adds to evidence that short-term response of ovarian function to weight loss in young women is less pronounced than long-term response in older women.
aDepartment of Anthropology, Harvard University Peabody Museum, Cambridge, Massachusetts
bDepartment of Anthropology and College of Medicine, University of Central Florida, Orlando, Florida
Reprint requests: Matthew McIntyre, Ph.D., S.M., Assistant Professor, Department of Anthropology and College of Medicine, University of Central Florida, 309 Howard Phillips Hall, 4000 Central Florida Blvd., Orlando, Florida, 32816.
J.F.C. has nothing to disclose. M.H.M. has nothing to disclose. S.F.L. has nothing to disclose. P.T.E. has nothing to disclose.
Supported by the Wenner-Gren Anthropological Association, the Woodrow Wilson-Johnson & Johnson Women's Health Dissertation Awards, and an NSF Dissertation Improvement Award.
ABSTRACT