Fertility and Sterility
Volume 91, Issue 4 , Pages 1104-1109 , April 2009

Consanguinity and family clustering of male factor infertility in Lebanon

  • Marcia C. Inhorn, Ph.D.

      Affiliations

    • Department of Health Behavior and Health Education, School of Public Health, University of Michigan, Ann Arbor, Michigan
    • Corresponding Author InformationReprint requests: Marcia C. Inhorn, Ph.D., Department of Health Behavior and Health Education, School of Public Health, University of Michigan, 109 S. Observatory, Ann Arbor, MI 48109-2029 (FAX: 734-763-7379).
    • ,
  • Loulou Kobeissi, Dr.P.H.

      Affiliations

    • American University of Beirut, Beirut, Lebanon
    • ,
  • Zaher Nassar, M.D.

      Affiliations

    • FIRST-IVF, Beirut, Lebanon
    • ,
  • Da'ad Lakkis, M.D.

      Affiliations

    • FIRST-IVF, Beirut, Lebanon
    • ,
  • Michael H. Fakih, M.D.

      Affiliations

    • FIRST-IVF, Beirut, Lebanon
    • IVF Michigan, Rochester Hills, Michigan

Received 20 August 2007 ,Revised 31 December 2007 ,Accepted 3 January 2008.

References 

  1. Gunaid AA, Hummad NA, Tamim KA. Consanguineous marriage in the capital city Sana'a, Yemen. J Biosoc Sci. 2004;36:111–121
  2. Bittles AH, Grant JC, Sullivan SG, Hussain R. Does inbreeding lead to decreased human fertility?. Ann Hum Biol. 2002;29:111–130
  3. Bittles AH, Manson WM, Greene J, Rao NA. Reproductive behavior and health in consanguineous marriages. Science. 1991;252:789–794
  4. El-Hazmi MA, Al-Swailem AR, Warsy AS, Al-Swailem AM, Sulaimani R, Al-Meshari A. Consanguinity among the Saudi Arabian population. J Med Genet. 1995;32:623–626
  5. Hussain R, Bittles AH. Assessment of association between consanguinity and fertility in Asian populations. J Health Popul Nutr. 2004;22:1–12
  6. Al Abdulkareem AA, Ballal SG. Consanguineous marriage in an urban area of Saudi Arabia: rates and adverse health effects on the offspring. J Community Health. 1998;23:75–83
  7. Al-Gazali LI, Bener A, Abdulrazzaq YM, Micallef R, Al-Khayat AI, Gaber T. Consanguineous marriages in the United Arab Emirates. J Biosoc Sci. 1997;29:491–497
  8. Baccetti B, Capitani S, Collodel G, Cairano G, Gambera L, Moretti E, et al. Genetic sperm defects and consanguinity. Hum Reprod. 2001;16:1365–1371
  9. Latini M, Gandini L, Lenzi A, Romanelli F. Sperm tail agenesis in a case of consanguinity. Fertil Steril. 2004;81:1688–1691
  10. Birenbaum-Carmeli D. Increased prevalence of Mediterranean and Muslim populations in mutation-related research literature. Community Genet. 2004;279:1–5
  11. Jurdi R, Saxena PC. The prevalence and correlates of consanguineous marriages in Yemen: similarities and contrasts with other Arab countries. J Biosoc Sci. 2003;35:1–13
  12. Hamamy H, Jamhawi L, Al-Darawsheh J, Ajlouni K. Consanguineous marriages in Jordan: why is the rate changing with time?. Clin Genet. 2005;67:511–516
  13. Saadat M, Ansari-Lari M, Farhud DD. Consanguineous marriage in Iran. Ann Hum Biol. 2004;2:263–269
  14. Sueyoshi S, Ohtsuka R. Effects of polygyny and consanguinity on high fertility in the rural Arab population of South Jordan. J Biosoc Sci. 2003;35:513–526
  15. Abbasi-Shavazi MJ, McDonald P, Hosseini-Chavoshi M. Modernization or cultural maintenance: the practice of consanguineous marriage in Iran. J Biosoc Sci. In press.
  16. In:  Teebi AS,  Farag TI editor. Genetic disorders among Arab populations. Oxford, United Kingdom: Oxford University Press; 1996;
  17. Rajab A, Patton MA. A study of consanguinity in the sultanate of Oman. Ann Hum Biol. 2000;27:321–326
  18. Zlotogora J. Genetic disorders among Palestinian Arabs. Am J Med Genet. 1997;68:472–475
  19. Inhorn MC. Middle Eastern masculinities in the age of new reproductive technologies: male infertility and stigma in Egypt and Lebanon. Med Anthropol Q. 2004;18:162–182
  20. Alkhalaf M, Verghese L, Muharib N. A cytogenetic study of Kuwaiti couples with infertility and reproductive disorders: short arm deletion of chromosome 21 is associated with male infertility. Ann Genet. 2002;45:147–149
  21. Mohammed F, Al-Yatama F, Al-Bader M, Tayel SM, Gouda S, Naguib KK. Primary male infertility in Kuwait: a cytogenetic and molecular study of 289 infertile Kuwaiti patients. Andrologia. 2007;39:87–92
  22. World Health Organization . Laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 4th ed.. New York: Cambridge University Press; 1999;
  23. Maduro MR, Lamb DJ. Understanding the new genetics of male infertility. J Urol. 2002;168:2197–2205
  24. Maduro MR, Lo KC, Chuang WW, Lamb DJ. Genes and male infertility: what can go wrong?. J Androl. 2003;24:485–493
  25. Chan P. Practical genetic issues in male infertility management. Paper presented at the American Society for Reproductive Medicine, 2007 Oct 13, Washington, DC.
  26. Krausz C, Forti G, McElreavey K. The Y chromosome and male fertility and infertility. Int J Androl. 2003;26:570–575
  27. Shah K, Sivapalan G, Gibbons N, Tempest H, Griffin DK. The genetic basis of infertility. Reproduction. 2003;126:13–25
  28. Inhorn MC. Local babies, global science: gender, religion, and in vitro fertilization in Egypt. New York: Routledge; 2003;
  29. Jabbra N. Family change in Lebanon's Biqa valley: what are the results of the civil war?. Journal of Comparative Family Studies. 2004;35:259–270
  30. Hussain R. Community perceptions of reasons for preference for consanguineous marriages in Pakistan. Am J Hum Biol. 1999;14:449–461
  31. Hussain R. Lay perceptions of genetic risks attributable to inbreeding in Pakistan. Am J Hum Biol. 2002;14:264–274
  32. Panter-Brick C. Parental responses to consanguinity and genetic disease in Saudi Arabia. Soc Sci Med. 1991;33:1295–1302

 Supported by the National Science Foundation (BCS 0549264) and U.S. Department of Education Fulbright-Hays Faculty Research Abroad Program.

PII: S0015-0282(08)00020-4

doi: 10.1016/j.fertnstert.2008.01.008

Fertility and Sterility
Volume 91, Issue 4 , Pages 1104-1109 , April 2009

Article Tools