Fertility and Sterility
Volume 91, Issue 4 , Pages 998-1004 , April 2009

Pathophysiologic features of “thin” endometrium

  • Ichiro Miwa, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan
  • ,
  • Hiroshi Tamura, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan
  • ,
  • Akihisa Takasaki, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Saiseikai Shimonoseki General Hospital, Shimonoseki, Japan
  • ,
  • Yoshiaki Yamagata, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan
  • ,
  • Katsunori Shimamura, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Saiseikai Shimonoseki General Hospital, Shimonoseki, Japan
  • ,
  • Norihiro Sugino, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan
    • Corresponding Author InformationReprint requests: Norihiro Sugino, M.D., Ph.D., Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Minamikogushi 1–1-1, Ube 755–8505, Japan (FAX: +81-836-22-2287).

Received 16 October 2007 ,Revised 7 January 2008 ,Accepted 7 January 2008.

References 

  1. Abdalla HI, Brooks AA, Johnson MR, Kirkland A, Thomas A, Studd JW. Endometrial thickness: a predictor of implantation in ovum recipients?. Hum Reprod. 1994;9:363–365
  2. Alam V, Bernardini L, Gonzales J, Asch RH, Balmaceda JP. A prospective study of echographic endometrial characteristics and pregnancy rates during hormonal replacement cycles. J Assist Reprod Genet. 1993;10:215–219
  3. Gonen Y, Casper RF, Jacobson W, Blankier J. Endometrial thickness and growth during ovarian stimulation: a possible predictor of implantation in in vitro fertilization. Fertil Steril. 1989;52:446–450
  4. Richter KS, Bugge KR, Bromer JG, Levy MJ. Relationship between endometrial thickness and embryo implantation, based on 1,294 cycles of in vitro fertilization with transfer of two blastocyst-stage embryos. Fertil Steril. 2007;87:53–59
  5. Hurst BS, Bhojwani JT, Marshburn PB, Papadakis MA, Loeb TA, Matthews ML. Low-dose aspirin does not improve ovarian stimulation, endometrial response, or pregnancy rates for in vitro fertilization. J Exp Clin Assist Reprod. 2005;2:8
  6. Urman B, Mercan R, Alatas C, Balaban B, Isiklar A, Nuhoglu A. Low-dose aspirin does not increase implantation rates in patients undergoing intracytoplasmic sperm injection: a prospective randomized study. J Assist Reprod Genet. 2000;17:586–590
  7. Weckstein LN, Jacobson A, Galen D, Hampton K, Hammel J. Low-dose aspirin for oocyte donation recipients with a thin endometrium: prospective, randomized study. Fertil Steril. 1997;68:927–930
  8. Gargett CE, Rogers PA. Human endometrial angiogenesis. Reproduction. 2001;121:181–186
  9. Matsuoka-Sakata A, Tamura H, Asada H, Miwa I, Taketani T, Sugino N. Changes in vascular leakage and expression of angiopoietins in the corpus luteum during pregnancy in rats. Reproduction. 2006;131:351–360
  10. Shimizu T, Jiang JY, Sasada H, Sato E. Changes of messenger RNA expression of angiogenic factors and related receptors during follicular development in gilts. Biol Reprod. 2002;67:1846–1852
  11. Shimizu T, Jiang JY, Iijima K, Miyabayashi K, Ogawa Y, Sasada H, et al. Induction of follicular development by direct single injection of vascular endothelial growth factor gene fragments into the ovary of miniature gilts. Biol Reprod. 2003;69:1388–1393
  12. Smith SK. Angiogenesis and implantation. Hum Reprod. 2000;15:59–66
  13. Sugino N, Suzuki T, Sakata A, Miwa I, Asada H, Taketani T, et al. Angiogenesis in the human corpus luteum: changes in expression of angiopoietins in the corpus luteum throughout the menstrual cycle and in early pregnancy. J Clin Endocrinol Metab. 2005;90:6141–6148
  14. Smith SK. Angiogenesis, vascular endothelial growth factor and the endometrium. Hum Reprod Update. 1998;4:509–519
  15. Kashida S, Sugino N, Takiguchi S, Karube A, Takayama H, Yamagata Y, et al. Regulation and role of vascular endothelial growth factor in the corpus luteum during mid-pregnancy in rats. Biol Reprod. 2001;64:317–323
  16. Sharkey AM, Day K, McPherson A, Malik S, Licence D, Smith SK, et al. Vascular endothelial growth factor expression in human endometrium is regulated by hypoxia. J Clin Endocrinol Metab. 2000;85:402–409
  17. Shifren JL, Tseng JF, Zaloudek CJ, Ryan IP, Meng YG, Ferrara N, et al. Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. J Clin Endocrinol Metab. 1996;81:3112–3118
  18. Sugino N, Kashida S, Karube-Harada A, Takiguchi S, Kato H. Expression of vascular endothelial growth factor (VEGF) and its receptors in human endometrium throughout the menstrual cycle and in early pregnancy. Reproduction. 2002;123:379–387
  19. Torry DS, Holt VJ, Keenan JA, Harris G, Caudle MR, Torry RJ. Vascular endothelial growth factor expression in cycling human endometrium. Fertil Steril. 1996;66:72–80
  20. Sher G, Fisch JD. Vaginal sildenafil (Viagra): a preliminary report of a novel method to improve uterine artery blood flow and endometrial development in patients undergoing IVF. Hum Reprod. 2000;15:806–809
  21. Sher G, Fisch JD. Effect of vaginal sildenafil on the outcome of in vitro fertilization (IVF) after multiple IVF failures attributed to poor endometrial development. Fertil Steril. 2002;78:1073–1076
  22. Chien LW, Au HK, Chen PL, Xiao J, Tzeng CR. Assessment of uterine receptivity by the endometrial-subendometrial blood flow distribution pattern in women undergoing in vitro fertilization–embryo transfer. Fertil Steril. 2002;78:245–251
  23. Friedler S, Schenker JG, Herman A, Lewin A. The role of ultrasonography in the evaluation of endometrial receptivity following assisted reproductive treatments: a critical review. Hum Reprod Update. 1996;2:323–335
  24. Chung TW, Chen TZ, Yu JJ, Lin SY, Chen SC. Effects of α-tocopherol nicotinate on hemorheology and retinal capillary blood flow in female NIDDM with retinopathy. Clin Hemorheol. 1995;15:775–782
  25. Chung TW, Yu JJ, Liu DZ. Reducing lipid peroxidation stress of erythrocyte membrane by α-tocopherol nicotinate plays an important role in improving blood rheological properties in type 2 diabetic patients with retinopathy. Diabetic Med. 1998;15:380–385
  26. Zaidi J, Campbell S, Pittrof R, Tan SL. Endometrial thickness, morphology, vascular penetration and velocimetry in predicting implantation in an in vitro fertilization program. Ultrasound Obstet Gynecol. 1995;6:191–198
  27. Ziegler WF, Bernstein I, Badger G, Leavitt T, Cerrero ML. Regional hemodynamic adaptation during the menstrual cycle. Obstet Gynecol. 1999;94:695–699
  28. Noyes RW, Herting AT, Rock J. Dating the endometrial biopsy. Fertil Steril. 1950;1:3–25
  29. Sugino N, Kashida S, Takiguchi S, Karube A, Kato H. Expression of vascular endothelial growth factor and its receptors in the human corpus luteum during the menstrual cycle and in early pregnancy. J Clin Endocrinol Metab. 2000;85:3919–3924
  30. Bernstein IM, Ziegler WF, Leavitt T, Badger GJ. Uterine artery hemodynamic adaptations through the menstrual cycle into early pregnancy. Obstet Gynecol. 2002;99:620–624
  31. Chakraborty I, Das SK, Dey SK. Differential expression of vascular endothelial growth factor and its receptor mRNAs in the mouse uterus around the time of implantation. J Endocrinol. 1995;147:339–352
  32. Das SK, Chakraborty I, Wang J, Dey SK, Hoffman LH. Expression of vascular endothelial growth factor (VEGF) and VEGF-receptor messenger ribonucleic acids in the peri-implantation rabbit uterus. Biol Reprod. 1997;56:1390–1399
  33. De Geyter C, Schmitter M, De Geyter M, Nieschlag E, Holzgreve W, Schneider HP. Prospective evaluation of the ultrasound appearance of the endometrium in a cohort of 1,186 infertile women. Fertil Steril. 2000;73:106–113
  34. Kovacs P, Matyas S, Boda K, Kaali SG. The effect of endometrial thickness on IVF/ICSI outcome. Hum Reprod. 2003;18:2337–2341
  35. Gonen Y, Casper RF. Prediction of implantation by the sonographic appearance of the endometrium during controlled ovarian stimulation for in vitro fertilization (IVF). J In Vitro Fert Embryo Transf. 1990;7:146–152
  36. Rashidi BH, Sadeghi M, Jafarabadi M, Tehrani Nejad ES. Relationships between pregnancy rates following in vitro fertilization or intracytoplasmic sperm injection and endometrial thickness and pattern. Eur J Obstet Gynecol Reprod Biol. 2005;120:179–184

 I.M. has nothing to disclose. H.T. has nothing to disclose. A.T. has nothing to disclose. Y.Y. has nothing to disclose. K.S. nothing to disclose. N.S. has nothing to disclose.

 Supported in part by grants-in-aid 17791121, 18791158, and 19791153 for Scientific Research from the Ministry of Education, Science, and Culture, Japan, and registered at clinicaltrials.gov.

PII: S0015-0282(08)00036-8

doi: 10.1016/j.fertnstert.2008.01.029

Fertility and Sterility
Volume 91, Issue 4 , Pages 998-1004 , April 2009