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Fertility and Sterility
Volume 91, Issue 4
, Pages 1135-1140
, April 2009
Evaluation of the relationship between plasma concentrations of en- and zuclomiphene and induction of ovulation in anovulatory women being treated with clomiphene citrate
References
- . WHO manual for the standardized investigation and diagnosis of the infertile couple. Cambridge, United Kingdom: Cambridge University Press; 1993;
- . Anovulatory infertility. Hum Reprod. 1995;10:1549–1553
- . Metformin in polycystic ovary syndrome: systematic review and meta-analysis. BMJ. 2003;327:951–953
- . What is the best first-step therapeutic approach in treating anovulatory infertility in patients with polycystic ovary syndrome? Questions that are still unanswered. Gynecol Endocrinol. 2007;23:245–247
- . Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction and achievement of pregnancy in 154 women with polycystic ovary syndrome. Fertil Steril. 2007;87:113–120
- . Clomiphene versus metformin for ovulation induction in polycystic ovary syndrome: the winner is. J Clin Endocrinol Metab. 2007;92:3399–3401
- Prospective parallel randomized, double-blind, double-dummy controlled clinical trial comparing clomiphene citrate and metformin as the first-line treatment for ovulation induction in nonobese anovulatory women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2005;90:4068–4074
- . A new era in ovulation induction. Fertil Steril. 2006;85:277–284
- . Metformin does not enhance ovulation induction in clomiphene resistant polycystic ovary syndrome in clinical practice. Br J Clin Pharmacol. 2002;53:469–473
- Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome. N Engl J Med. 2007;356:551–566
- . Effect of clomifene citrate plus metformin and clomifene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomised double blind clinical trial. BMJ. 2006;332:1485
- . Clomiphene citrate for ovulation induction in women with oligo-amenorrhoea. Cochrane Database Syst Rev. 2000;(2):CD000056
- . Prediction of the individual follicle-stimulating hormone threshold for gonadotropin induction of ovulation in normogonadotropic anovulatory infertility: an approach to increase safety and efficiency. Fertil Steril. 2002;77:83–90
- . Predictors of patients remaining anovulatory during clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility. J Clin Endocrinol Metab. 1998;83:2361–2365
- . Predictors of chances to conceive in ovulatory patients during clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility. J Clin Endocrinol Metab. 1999;84:1617–1622
- . A nomogram to predict the probability of live birth after clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility. Fertil Steril. 2002;77:91–97
- . Relationship of clomiphene dose and patient weight to successful treatment. Hum Reprod. 1997;12:449–453
- . Rabbit liver microsomal metabolism of enclomiphene. Drug Metab Dispos. 1981;9:456–460
- . Biotransformation of the antiestrogen clomiphene to chemically reactive metabolites in the immature female rat. Cancer Res. 1987;47:4015–4019
- . Metabolism of clomiphene in the rat. Estrogen receptor affinity and antiestrogenic activity of clomiphene metabolites. Biochem Pharmacol. 1983;32:2941–2947
- . Monitoring plasma concentrations to individualize treatment with clomiphene citrate. Fertil Steril. 2004;81:1187–1193
- . Stereochemistry of geometric isomers of clomiphene: a correction of the literature and a reexamination of structure-activity relationships. J Pharm Sci. 1976;65:148–150
- . Clinical guide to laboratory tests. Philadelphia: W.B. Saunders; 1995;
- . Endocrinological and endometrial factors in recurrent miscarriage. BJOG. 2000;107:1471–1479
- . Determination by liquid chromatography-mass spectrometry of clomiphene isomers in the plasma of patients undergoing treatment for the induction of ovulation. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;847:296–299
- . Multiple imputation for multivariate data with missing and below-threshold measurements: time-series concentrations of pollutants in the Arctic. Biometrics. 2001;57:22–33
- . Ways to fit a PK model with some data below the quantification limit. J Pharmacokinet Pharmacodyn. 2001;28:481–504
- . Serum concentrations of enclomiphene and zuclomiphene across consecutive cycles of clomiphene citrate therapy in anovulatory infertile women. Fertil Steril. 1999;71:639–644
- . Single-dose pharmacokinetics of clomiphene citrate in normal volunteers. Fertil Steril. 1986;46:392–396
- Ghobadi C, Gregory A, Crewe HK, Rostami-Hodjegan A, Lennard MS. CYP2D6 is primarily responsible for the metabolism of clomiphene. Drug Metab Pharmacokinet. In press.
- The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen. Breast Cancer Res Treat. 2007;101:113–121
- . CYP2D6 polymorphisms and the impact on tamoxifen therapy. J Pharm Sci. 2007;96:2224–2231
- . Variable contribution of cytochromes P450 2D6, 2C9 and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes. Biochem Pharmacol. 1997;53:171–178
- . Incorporating in vitro information on drug metabolism into clinical trial simulations to assess the effect of CYP2D6 polymorphism on pharmacokinetics and pharmacodynamics: dextromethorphan as a model application. J Clin Pharmacol. 2007;47:175–186
C.G. has nothing to disclose. S.A. has nothing to disclose. H.L. has nothing to disclose. M.S.L. has nothing to disclose. W.L.L. has nothing to disclose. A.R.-H. has nothing to disclose.
C.G. is a Ph.D. candidate, and the present work constitutes part of his thesis.
PII: S0015-0282(08)00153-2
doi: 10.1016/j.fertnstert.2008.01.058
© 2009 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
« Previous
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Fertility and Sterility
Volume 91, Issue 4
, Pages 1135-1140
, April 2009

