Fertility and Sterility
Volume 91, Issue 4, Supplement , Pages 1303-1306, April 2009

Cyclooxygenase-2 overexpression in ovarian endometriomas is associated with higher risk of recurrence

  • Lei Yuan, M.D.

      Affiliations

    • Department of Gynecology, Shanghai Obstetrics and Gynecology Hospital, and Department of Gynecology and Obstetrics, Shanghai Medical School, Fudan University, Shanghai, China
    • ,
  • Fanghua Shen

      Affiliations

    • Department of Gynecology, Shanghai Obstetrics and Gynecology Hospital, and Department of Gynecology and Obstetrics, Shanghai Medical School, Fudan University, Shanghai, China
    • ,
  • Yuan Lu, M.D., Ph.D.

      Affiliations

    • Department of Gynecology, Shanghai Obstetrics and Gynecology Hospital, and Department of Gynecology and Obstetrics, Shanghai Medical School, Fudan University, Shanghai, China
    • ,
  • Xishi Liu, M.D., Ph.D.

      Affiliations

    • Department of Gynecology, Shanghai Obstetrics and Gynecology Hospital, and Department of Gynecology and Obstetrics, Shanghai Medical School, Fudan University, Shanghai, China
    • ,
  • Sun-Wei Guo, Ph.D.

      Affiliations

    • Institute of Obstetric and Gynecologic Research, Shanghai Jiao-Tong University School of Medicine, Renji Hospital, Shanghai, China
    • Corresponding Author InformationReprint requests: Sun-Wei Guo, Ph.D., Institute of Obstetric and Gynecologic Research, Shanghai Jiao Tong University School of Medicine, Renji Hospital, 145 Shangdong Zhong Road, Shanghai 200001, People's Republic of China (FAX: 86-21-5889-0018).

Received 30 October 2007; received in revised form 17 January 2008; accepted 17 January 2008. published online 25 March 2008.

Cyclooxegenase-2 expression was evaluated by immunohistochemistry in endometrioma tissue samples taken from 109 patients, of whom 53 had recurrence by 30 months after surgery and 56 did not. Cyclooxegenase-2 overexpression, along with previous medical treatment of endometriosis and the presence of adhesion, is predictive of recurrence of ovarian endometrioma within 30 months after surgery, with a resultant sensitivity of 72.5% and a specificity of 72.4%, suggesting that there are intrinsic and identifiable biomarkers that confer recurrence risk.

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 L.Y. has nothing to disclose. F.S. has nothing to disclose. Y.L. has nothing to disclose. X.L. has nothing to disclose. S.-W.G. has nothing to disclose.

 L.Y. and F.S. contributed equally to this work.

PII: S0015-0282(08)00164-7

doi:10.1016/j.fertnstert.2008.01.070

Fertility and Sterility
Volume 91, Issue 4, Supplement , Pages 1303-1306, April 2009

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