Fertility and Sterility
Volume 91, Issue 4 , Pages 1018-1022 , April 2009

Luteal phase estradiol level: a potential predictive marker for successful pregnancy in in vitro fertilization/intracytoplasmic sperm injection

  • Ashalatha Ganesh, M.B.B.S., M.M.S.T.

      Affiliations

    • School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, India
    • Institute of Reproductive Medicine, Salt Lake, Kolkata, India
    • Corresponding Author InformationReprint requests: Ashalatha Ganesh, M.B.B.S., School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal 721 302, India (FAX: 91-03222-282221).
  • ,
  • Sourendrakant Goswami, M.B.B.S.

      Affiliations

    • Institute of Reproductive Medicine, Salt Lake, Kolkata, India
  • ,
  • Ratna Chattopadhyay, M.B.B.S.

      Affiliations

    • Institute of Reproductive Medicine, Salt Lake, Kolkata, India
  • ,
  • Chandan Chakraborty, Ph.D.

      Affiliations

    • School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, India
  • ,
  • Koel Chaudhury, Ph.D.

      Affiliations

    • School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, India
  • ,
  • Baidya Nath Chakravarty, M.D., F.R.C.O.G.

      Affiliations

    • Institute of Reproductive Medicine, Salt Lake, Kolkata, India

Received 8 November 2007 ,Revised 16 January 2008 ,Accepted 21 January 2008.

References 

  1. Stewart DR, Overstreet JW, Nakajima ST, Lasley BL. Enhanced ovarian steroid secretion before implantation in early human pregnancy. J Clin Endocrinol Metab. 1993;76:1470–1476
  2. Vicdan K, Isik AZ. Luteal phase hormonal profile in prediction of pregnancy outcome after assisted reproduction. Eur J Obstet Gynecol Reprod Biol. 2001;96:98–101
  3. Gruber I, Just A, Birner M, Losch A. A Serum estradiol/progesterone ratio on day of embryo transfer may predict reproductive outcome following controlled ovarian hyperstimulation and in vitro fertilization. J Exp Clin Assist Reprod. 2007;4:1
  4. Balasch J, Creus M, Fabregues F, Carmona F, Casamitjana R, Penarrubia J, et al. Hormonal profiles in successful and unsuccessful implantation in IVF-ET after combined GnRH agonist/gonadotropin treatment for superovulation and hCG luteal support. Gynecol Endocrinol. 1995;l9:51–58
  5. Baird DD, Wilcox AJ, Weinberg CR, Kamel F, McConnaughey DR, Musey PI, et al. Preimplantation hormonal differences between the conception and non-conception menstrual cycles of 32 normal women. Hum Reprod. 1997;12:2607–2613
  6. Aktan E, Kaan B, Dilek O, Yucebilgin S, Karadadas M, Bilgin O. The effect of mid-luteal estradiol level on the outcome of ICSI-ET cycles. Arch Gynecol Obstet. 2004;269:134–138
  7. Laufer N, Navot D, Schenker JG. The pattern of luteal phase plasma progesterone and estradiol in fertile couples. Am J Obstet Gynecol. 1981;143:808–813
  8. Muasher SJ, Acosta AA, Garcia J, Jones GS, Jones HW. Luteal phase serum estradiol and progesterone in in vitro fertilization. Fertil Steril. 1984;41:838–843
  9. Smitz J, Devroey P, Camus M, Deschacht J, Khan I, Staessen C, et al. The luteal phase and early pregnancy after combined GnRH-agonist/HMG treatment for superovulation in IVF or GIFT. Hum Reprod. 1988;3:585–590
  10. Fujimoto A, Osuga Y, Fujiwara T, Yano T, Tsutsumi O, Momoeda M, et al. Human chorionic gonadotropin combined with progesterone for luteal support improves pregnancy rate in patients with low late-mid-luteal estradiol levels in IVF Cycles. J Assist Reprod Genet. 2002;19:550–554
  11. Nylund L, Beskow C, Carlstrom K, Fredricsson B, Gustafson O, Lunell NO, et al. The early luteal phase in successful and unsuccessful implantation after IVF-ET. Hum Reprod. 1990;5:40–42
  12. Smitz J, Bourgain C, Van Waesberghe L, Camus M, Devroey P, Van Steirteghem AC. A prospective randomized study on oestradiol valerate supplementation in addition to intravaginal micronized progesterone in buserelin and HMG induced superovulation. Hum Reprod. 1993;8:40–45
  13. Friedler S, Zimerman A, Schachter M, Raziel A, Strassburger D, Ron El R. The midluteal decline in serum estradiol levels is drastic but not deleterious for implantation after in vitro fertilization and embryo transfer in patients with normal or high responses. Fertil Steril. 2005;83:54–60
  14. Ng EHY, Yeung WSB, Lau EYL, So WWK, Ho PC. A rapid decline in serum estradiol concentrations around the mid-luteal phase had no adverse affect on outcome in 763 assisted reproduction cycles. Hum Reprod. 2000;15:1903–1908
  15. Costello MF, Emerson S, Lukic J, Sjoblom P, Garrett D, Hughes G, et al. Predictive value of mid-luteal progesterone concentration before luteal support in controlled ovarian hyperstimulation with intrauterine insemination. Aust N Z J Obstet Gynaecol. 2004;44:51–56
  16. Ioannidis G, Sacks G, Reddy N, Seyani L, Margara R, Lavery S, et al. Day 14 maternal serum progesterone levels predict pregnancy outcome in IVF/ICSI treatment cycles: a prospective study. Hum Reprod. 2005;20:741–746
  17. Daily CA, Laurent SL, Nunley WC. The prognostic value of serum progesterone and quantitative beta-human chorionic gonadotropin in early human pregnancy. Am J Obstet Gynecol. 1994;171:380–383
  18. Ledger WL, Sweeting VM, Chatterjee S. Rapid diagnosis of early ectopic pregnancy in an emergency gynaecology service—are measurements of progesterone, intact and free beta human chorionic gonadotrophin helpful?. Hum Reprod. 1994;9:157–160
  19. Mol BW, Lijmer JG, Ankum WM, Van der Veen F, Bossuyt PM. The accuracy of single serum progesterone measurement in the diagnosis of ectopic pregnancy: a meta-analysis. Hum Reprod. 1998;13:3220–3227
  20. Edgar DH. Estrogen and human implantation. Hum Reprod. 1995;10:2–4
  21. Greb RR, Lettmann N, Sonntag B, Schüring AN, von Otte S, Kiesel L. Enhanced oestradiol secretion briefly after embryo transfer in conception cycles from IVF. Reprod Biomed Online. 2004;9:271–278
  22. Liu HC, Kreiner D, Muasher SJ, Jones GS, Jones HW, Rosenwaks Z. Beta-human chorionic gonadotropin as monitor of pregnancy outcome in in-vitro fertilization embryo transfer patients. Fertil Steril. 1988;50:89–94
  23. Speroff L, Glass RH, Kase NG. Clinical gynecologic endocrinology and infertility. 6th ed.. Philadelphia: Lippincott Williams & Wilkins; 1999;
  24. Liu HC, Davis O, Berkley A, Graft M, Rosenwaks Z. Late luteal estradiol patterns are better prognosticator of pregnancy outcome than serial beta-human chorionic gonadotropin concentrations. Fertil Steril. 1991;56:421–426
  25. Sharara FI, McClamrock HD. Ratio of oestradiol concentration on the day of human chorionic gonadotrophin administration to mid-luteal oestradiol concentration is predictive of in-vitro fertilization outcome. Hum Reprod. 1999;14:2777–2782
  26. Elson J, Salim R, Tailor A, Banerjee S, Zosmer N, Jurkovic D. Prediction of early pregnancy viability in the absence of an ultrasonically detectable embryo. Ultrasound Obstet Gynecol. 2002;21:57–61

 A.G. has nothing to disclose. S.G. has nothing to disclose. R.C. has nothing to disclose. C.C. has nothing to disclose. K.C. has nothing to disclose. B.N.C. has nothing to disclose.

PII: S0015-0282(08)00168-4

doi: 10.1016/j.fertnstert.2008.01.074

Fertility and Sterility
Volume 91, Issue 4 , Pages 1018-1022 , April 2009