Fertility and Sterility
Volume 91, Issue 6 , Pages 2593-2595 , June 2009

Foreign fetal cells persist in the maternal circulation

  • Zev Williams, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
    • Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts
    • Corresponding Author InformationReprint requests: Zev Williams M.D., Ph.D., Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115 (FAX: 617-730-2833).
    • ,
  • Dimity Zepf, B.A.

      Affiliations

    • Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
    • ,
  • Janina Longtine, M.D.

      Affiliations

    • Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
    • ,
  • Raymond Anchan, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
    • ,
  • Betsy Broadman, J.D.

      Affiliations

    • Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
    • ,
  • Stacey A. Missmer, Ph.D.

      Affiliations

    • Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
    • Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
    • Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
    • ,
  • Mark D. Hornstein, M.D.

      Affiliations

    • Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts

Received 23 October 2007 ,Revised 5 February 2008 ,Accepted 5 February 2008.

References 

  1. Bianchi DW, Zickwolf GK, Weil GJ, Sylvester S, DeMaria MA. Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum. Proc Natl Acad Sci U S A. 1996;93:705–708
  2. Khosrotehrani K, Johnson KL, Cha DH, Salomon RN, Bianchi DW. Transfer of fetal cells with multilineage potential to maternal tissue. JAMA. 2004;292:75–80
  3. Srivatsa B, Srivatsa S, Johnson KL, Samura O, Lee SL, Bianchi DW. Microchimerism of presumed fetal origin in thyroid specimens from women: a case-control study. Lancet. 2001;358:2034–2038
  4. Johnson KL, Samura O, Nelson JL, McDonnell WM, Bianchi DW. Significant fetal cell microchimerism in a nontransfused woman with hepatitis C: evidence of long-term survival and expansion. Hepatology. 2002;36:1295–1297
  5. Lo YM, Corbetta N, Chamberlain PF, Rai V, Sargent IL, Redman CW, et al. Presence of fetal DNA in maternal plasma and serum. Lancet. 1997;350:485–487
  6. Rosenwaks Z, Veeck LL, Liu HC. Pregnancy following transfer of in vitro fertilized donated oocytes. Fertil Steril. 1986;45:417–420
  7. Mehta YM, Patel NR. Exact logistic regression: theory and examples. Stat Med. 1995;14:2143–2160
  8. Evans PC, Lambert N, Maloney S, Furst DE, Moore JM, Nelson JL. Long-term fetal microchimerism in peripheral blood mononuclear cell subsets in healthy women and women with scleroderma. Blood. 1999;93:2033–2037
  9. Nguyen Huu S, Dubernard G, Aractingi S, Khosrotehrani K. Feto-maternal cell trafficking: a transfer of pregnancy associated progenitor cells. Stem Cell Rev. 2006;2:111–116
  10. De Coppi P, Bartsch G, Siddiqui MM, Xu T, Santos CC, Perin L, et al Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol. 2007;25:100–106
  11. Chung Y, Klimanskaya I, Becker S, Marh J, Lu SJ, Johnson J, et al Embryonic and extraembryonic stem cell lines derived from single mouse blastomeres. Nature. 2006;439:216–219

 Z.W. has nothing to disclose. D.Z. has nothing to disclose. J.L. has nothing to disclose. R.A. has nothing to disclose. B.B. has nothing to disclose. S.A.M. has nothing to disclose. M.D.H. has nothing to disclose.

 Supported by an Expanding the Boundaries grant from the Department of Obstetrics and Gynecology, Brigham and Women's Hospital.

PII: S0015-0282(08)00249-5

doi: 10.1016/j.fertnstert.2008.02.008

Fertility and Sterility
Volume 91, Issue 6 , Pages 2593-2595 , June 2009

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