Fertility and Sterility
Volume 91, Issue 5 , Pages 1646-1653 , May 2009

Safety and efficacy of a single-rod etonogestrel implant (Implanon): results from 11 international clinical trials

  • Philip Darney, M.D.

      Affiliations

    • Bixby Center for Global Reproductive Health, San Francisco General Hospital, University of California, San Francisco, California
    • Corresponding Author InformationReprint requests: Philip D. Darney, M.D., M.Sc., San Francisco General Hospital 6D, 1001 Potrero Avenue, San Francisco, CA 94941.
    • ,
  • Ashlesha Patel, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, John H. Stroger Jr. Hospital of Cook County, Chicago, Illinois
    • ,
  • Kimberly Rosen, M.D.

      Affiliations

    • Organon USA, Roseland, New Jersey
    • ,
  • Lena S. Shapiro, Ph.D.

      Affiliations

    • Organon USA, Roseland, New Jersey
    • ,
  • Andrew M. Kaunitz, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, University of Florida College of Medicine, Jacksonville, Florida

Received 15 October 2007 ,Revised 21 February 2008 ,Accepted 21 February 2008.

References 

  1. Brache V, Faundes A, Alvarez F. Risk-benefit effects of implantable contraceptives in women. Expert Opin Drug Safety. 2003;2:321–332
  2. Croxatto HB, Urbancsek J, Massai R, Coelingh Bennink H, van Beek A Implanon Study Group. A multicentre efficacy and safety study of the single contraceptive implant Implanon. Hum Reprod. 1999;14:976–981
  3. Belsey EM, Machin D, d'Arcangues C. The analysis of vaginal bleeding patterns induced by fertility regulating methods. Contraception. 1986;34:253–260
  4. Erkkola R, Landgren BM. Role of progestins in contraception. Acta Obstet Gynecol Scand. 2005;84:207–216
  5. Shulman LP. Advances in female hormonal contraception: current alternatives to oral regimens. Treat Endocrinol. 2003;2:247–256
  6. David PS, Boatwright EA, Tozer BS, Verma DP, Blair JE, Mayer AP, et al. Hormonal contraception update. Mayo Clin Proc. 2006;81:949–954
  7. Trussell J. Contraceptive failure in the United States. Contraception. 2004;70:89–96
  8. National Institute for Health and Clinical Excellence. Long acting reversible contraception. Clinical guideline 30. October 2005. Available at: http://guidance.nice.org.uk/CG30/guidance/pdf/English. Accessed April 13, 2007.
  9. Peterson HB, Xia Z, Hughes JM, Wilcox LS, Ratliff Taylor L, Trussell J U.S. Collaborative Review of Sterilization Working Group. The risk of pregnancy after tubal sterilization: findings from the U.S. Collaborative Review of Sterilization. Contraception. 1996;174:1161–1170
  10. Harrison-Woolrych M, Hill R. Unintended pregnancies with the etonogestrel implant (Implanon): a case series from postmarketing experience in Australia. Contraception. 2005;71:306–308
  11. Piessens SG, Palmer DC, Sampson AJ. Ultrasound localisation of nonpalpable Implanon. Aust N Z J Obstet Gynaecol. 2005;45:112–116
  12. Shoupe D, Mishell DR, Bopp BL, Fielding M. The significance of bleeding patterns in Norplant implant users. Obstet Gynecol. 1991;77:256–260
  13. Darney PD, Klaisle CM. Contraception-associated menstrual problems: etiology and management. Dialogues Contraception. 1998;5:1–6
  14. Zheng SR, Zheng HM, Qian SZ Sang GW, Kaper RF. A randomized multicenter study comparing the efficacy and bleeding pattern of a single-rod (Implanon) and a six-capsule (Norplant) hormonal contraceptive implant. Contraception. 1999;60:1–8

 Supported by Organon.

 Dr. Darney has received research funding from Organon and has served as an advisor to Organon. Dr. Patel has served on the Speakers' Bureau for Organon. Dr. Kaunitz has received research funding from Barr, Bayer, Organon, and Warner-Chilcott and has served as a speaker and/or consultant for the American College of Obstetricians and Gynecologists, Barr, Bayer, Johnson and Johnson, Organon, and Warner-Chilcott. Dr. Rosen has nothing to disclose. D. Shapiro has nothing to disclose.

PII: S0015-0282(08)00515-3

doi: 10.1016/j.fertnstert.2008.02.140

Fertility and Sterility
Volume 91, Issue 5 , Pages 1646-1653 , May 2009

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