Fertility and Sterility
Volume 91, Issue 6 , Pages 2361-2368 , June 2009

Attitudes of high-risk women toward preimplantation genetic diagnosis

  • Gwendolyn Quinn, Ph.D.

      Affiliations

    • University of South Florida, Tampa, Florida
    • Moffitt Cancer Center, Tampa, Florida
    • Corresponding Author InformationReprint requests: Gwendolyn Quinn, Ph.D., 12902 Magnolia Drive, MRC-CANCONT, Tampa, FL 33612 (FAX: 813-745-6525).
    • ,
  • Susan Vadaparampil, Ph.D., M.P.H.

      Affiliations

    • University of South Florida, Tampa, Florida
    • Moffitt Cancer Center, Tampa, Florida
    • ,
  • Crystal Wilson, B.A.

      Affiliations

    • Moffitt Cancer Center, Tampa, Florida
    • ,
  • Lindsey King, M.P.H., C.H.E.S.

      Affiliations

    • Moffitt Cancer Center, Tampa, Florida
    • ,
  • Jimin Choi, Ph.D.

      Affiliations

    • Moffitt Cancer Center, Tampa, Florida
    • ,
  • Cheryl Miree, M.S.

      Affiliations

    • Moffitt Cancer Center, Tampa, Florida
    • ,
  • Sue Friedman, D.V.M.

      Affiliations

    • Moffitt Cancer Center, Tampa, Florida
    • Facing Our Risk of Cancer Empowered (FORCE), Tampa, Florida

Received 7 January 2008 ,Revised 5 March 2008 ,Accepted 7 March 2008.

References 

  1. Marik JJ. Preimplantation genetic diagnosis. E-Medicine 2005. Available at: http://www.emedicine.com/med/topic3520.htm#section∼bibliography. Accessed on November 26, 2007.
  2. Coutelle C, Williams C, Handyside A, Hardy K, Winston R, Williamson R. Genetic analysis of DNA from single human oocytes: a model for preimplantation diagnosis of cystic fibrosis. BMJ. 1989;299:22–24
  3. Holding C, Monk M. Diagnosis of beta-thalassaemia by DNA amplification in single blastomeres from mouse preimplantation embryos. Lancet. 1989;2:532–535
  4. Handyside AH, Kontogianni EH, Hardy K, Winston RM. Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification. Nature. 1990;344:768–770
  5. Zitner A. The nation: cloning receives a makeover politics: nuances of language helped reframe the debate and derail an all-out ban in congress. L.A. Times 2002 Jun 17, 2007;Sect. A1.
  6. Sermon K. Preimplantation genetic diagnosis. Lancet. 2004;363:1633–1641
  7. Baruch S, Kaufman D, Hudson K. Genetic testing of embryos: practices and perspectives of U.S IVF clinics. Fertil Steril. Published online September 20, 2006 [online only].
  8. Offit K, Kohut K, Clagett B, Wadsworth EA, Lafaro KJ, Cummings S, et al. Cancer genetic testing and assisted reproduction. J Clin Oncol. 2006;24:4775–4782
  9. Reproductive Health Technologies Project. 2006. Available at: http://www.rhtp.org/fertility/pgd/default.asp. Accessed on November 7, 2007.
  10. American Society of Reproductive Medicine. 2006. Available at: http://www.asrm.org/Media/Press/AM07asrmpgd.html. Accessed on November 7, 2007.
  11. Testart J, Sele B. Towards an efficient medical eugenics: is the desirable always the feasible?. Hum Reprod. 1995;10:3086–3090
  12. Carter RF. BRCA1, BRCA2 and breast cancer: a concise clinical review. Clin Invest Med. 2001;24:147–157
  13. Chen S, Iversen ES, Friebel T, Finkelstein D, Weber BL, Eisen A, et al. Characterization of BRCA1 and BRCA2 mutations in a large United States sample. J Clin Oncol. 2006;24:863–871
  14. HFEA. Choices and Boundaries Report. 2006. Available at: http://www.hfea.gov.uk/docs/Choices_and_boundaries_Report_2006.pdf. Accessed on September 15, 2007.
  15. Hudson K. Public awareness and attitudes about reproductive genetic technology. Washington, DC: Genetics and Public Policy Center; 2002;
  16. Hudson KL. Preimplantation genetic diagnosis: public policy and public attitudes. Fertil Steril. 2006;85:1638–1645
  17. Menon U. Views of BRCA gene mutation carriers on preimplantation genetic diagnosis as a reproductive option for hereditary breast and ovarian cancer. Hum Reprod. 2007;22:1573–1577
  18. CftDot Faith. Instruction on respect for human life in its origin and on the dignity of procreation. Washington, DC: USCCB Publishing; 1987;
  19. Wideroff L, Vadaparampil ST, Breen N, Croyle RT, Freedman AN. Awareness of genetic testing for increased cancer risk in the year 2000 National Health Interview Survey. Community Genet. 2003;6:147–156
  20. Staton AD, Kurian AW, Cobb K, Mills MA, Ford JM. Cancer risk reduction and reproductive concerns in female BRCA1/2 mutation carriers. Fam Cancer. 2007;

 G.Q. has nothing to disclose. S.V. has nothing to disclose. C.W. has nothing to disclose. L.K. has nothing to disclose. J.C. has nothing to disclose. C.M. has nothing to disclose. S.F. has nothing to disclose.

 Supported in part by the Survey Methods Core Facility at the H. Lee Moffitt Cancer Center & Research Institute and RSGPB-07-019-01-CPPB, American Cancer Society, Atlanta, GA.

PII: S0015-0282(08)00590-6

doi: 10.1016/j.fertnstert.2008.03.019

Fertility and Sterility
Volume 91, Issue 6 , Pages 2361-2368 , June 2009

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