Fertility and Sterility
Volume 91, Issue 6 , Pages 2451-2454 , June 2009

Embryonic heart rate as a predictor of first-trimester pregnancy loss in infertility patients after in vitro fertilization

  • Eden R. Rauch, M.D., M.P.H.

      Affiliations

    • Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, New York
    • Corresponding Author InformationReprint requests: Eden R. Rauch, M.D., M.P.H., Center for Reproductive Medicine and Infertility, 1305 York Avenue, 7th Floor, New York, New York 10021 (FAX: 212-746-8208).
    • ,
  • Glenn L. Schattman, M.D.

      Affiliations

    • Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, New York
    • ,
  • Paul J. Christos, M.P.H., M.S.

      Affiliations

    • Division of Biostatistics and Epidemiology, Department of Public Health, Weill Medical College of Cornell University, New York, New York
    • ,
  • Ty Chicketano, M.S.

      Affiliations

    • Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, New York
    • ,
  • Zev Rosenwaks, M.D.

      Affiliations

    • Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, New York

Received 30 August 2007 ,Revised 10 March 2008 ,Accepted 10 March 2008.

References 

  1. Montenegro N, Ramos C, Matias A, Barros H. Variation of embryonic/fetal heart rate at 6–13 weeks' gestation. Ultrasound Obstet Gynecol. 1998;11:274–276
  2. Tezuka N, Sato S, Kanasugi H, Hiroi M. Embryonic heart rate: development in early first trimester and clinical evaluation. Gynecol Obstet Invest. 1991;32:210–212
  3. Doubilet PM, Benson CB, Chow JA. Long-term prognosis of pregnancies complicated by slow embryonic heart rates in the early first trimester. J Ultrasound Med. 1999;18:537–541
  4. Doubilet PM, Benson CB, Chow JA. Outcome of pregnancies with rapid embryonic heart rates in the early first trimester. AJR. 2000;175:67–69
  5. Simpson JL, Mills JL, Holmes LB, Ober C, Aarons J, Jovanovic L, et al. Low fetal loss rates after ultrasound-proven viability in early pregnancy. JAMA. 1987;258:2555–2557
  6. Benson CB, Doubilet PM. Slow embryonic heart rate in early first trimester: indicator of poor pregnancy outcome. Radiology. 1994;192:343–344
  7. Spandorfer SD, Davis OK, Barmat LI, Chung PH, Rosenwaks Z. Relationship between maternal age and aneuploidy in in vitro fertilization pregnancy loss. Fertil Steril. 2004;81:1265–1269
  8. Hyer JS, Fong S, Kutteh WH. Predictive value of the presence of an embryonic heartbeat for live birth: comparison of women with and without recurrent pregnancy loss. Fertil Steril. 2004;82:1369–1373
  9. Davis OK, Rosenwaks Z. In vitro fertilization. In:  Adashi E,  Rock JA,  Rosenwaks Z editor. Reproductive endocrinology, surgery, and technology. Philadelphia: Lippincott-Raven; 1996;p. 2319–2334
  10. Tummers P, De Sutter P, Dhont M. Risk of spontaneous abortion in singleton and twin pregnancies after IVF/ICSI. Hum Reprod. 2003;18:1720–1723
  11. Smith KE, Buyalos RP. The profound effect of patient age on pregnancy outcome after early detection of fetal cardiac activity. Fertil Steril. 1996;65:35–40
  12. Andersen N, Wohlfahrt J, Christens P, Olsen J, Melbye M. Maternal age and fetal loss: population based register linkage study. Br Med J. 2000;320:1708–1712
  13. Hanprasertpong T, Phopong V. First trimester embryonic/fetal heart rate in normal pregnant women. Arch Gynecol Obstet. 2006;274:257–260
  14. Qasim SM, Sachdev R, Trias A, Senkowski K, Kemmann E. The predictive value of first-trimester embryonic heart rates in infertility patients. Obstet Gynecol. 1997;89:934–936

 E.R. has nothing to disclose. G.S. has nothing to disclose. P.C. has nothing to disclose. T.C. has nothing to disclose. Z.R. has nothing to disclose.

 Presented at the American Society or Reproductive Medicine, Montreal, Canada, November 2005.

PII: S0015-0282(08)00597-9

doi: 10.1016/j.fertnstert.2008.03.026

Fertility and Sterility
Volume 91, Issue 6 , Pages 2451-2454 , June 2009

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