Association between polymorphisms in the protein L-isoaspartate (D-aspartate) O-methyltransferase gene and premature ovarian failure
Received 26 November 2007; received in revised form 28 March 2008; accepted 28 March 2008. published online 25 June 2008.
We found that four polymorphisms in the protein L-isoaspartyl-O-methyltransferase (PCMT1) gene, encoding a protein repair enzyme, are associated with premature ovarian failure (POF). All four polymorphisms were in strong linkage disequilibrium. The frequencies of two haplotypes were statistically significantly different between the POF group and the matched control group.
Medical Genomics Laboratory, Pochon CHA University, Gyeonggi-do, South Korea
Reprint requests: KyuBum Kwack, Ph.D., Medical Genomics Laboratory, CHA Research Institute, Bundang Campus, Pochon CHA University, 222 Yatap-dong, Bundang-gu, Seongnam, Gyeonggi-do 463-836, Republic of Korea (FAX: 82-31-725-8350).
Supported by grants from Ministry of Health and Welfare, Republic of Korea (01-PJ10-PG6-01GN13-0002 and 0405-BC02-0604-0004).
J-A.P. has nothing to disclose. HJ.K. has nothing to disclose. S.K.L. has nothing to disclose. M.K. has nothing to disclose. KB.K. has nothing to disclose.
ABSTRACT