Fertility and Sterility
Volume 91, Issue 5, Supplement , Pages 2020-2024 , May 2009

Expression and localization of the novel and highly conserved gametocyte-specific factor 1 during oogenesis and spermatogenesis

  • Stephan P. Krotz, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas
    • Division of Reproductive Endocrinology, Women and Infants' Hospital of Rhode Island, Warren Alpert Medical School, Brown University, Providence, Rhode Island
    • Corresponding Author InformationReprint requests: Stephan Krotz, M.D., 101 Dudley Street, Division of Reproductive Endocrinology & Infertility, Providence, RI 02905 (FAX: 401-276-7845).
    • ,
  • Daniel J. Ballow, B.A.

      Affiliations

    • Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas
    • ,
  • Youngsok Choi, Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas
    • ,
  • Aleksandar Rajkovic, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas

Received 9 April 2008 ,Revised 14 May 2008 ,Accepted 15 May 2008.

References 

  1. Choi Y, Rajkovic A. Genetics of early mammalian folliculogenesis. Cell Mol Life Sci. 2006;63:579–590
  2. Lawson KA, Hage WJ. Clonal analysis of the origin of primordial germ cells in the mouse. Ciba Found Symp. 1994;182:68–84discussion 84–91
  3. McClellan KA, Gosden R, Taketo T. Continuous loss of oocytes throughout meiotic prophase in the normal mouse ovary. Dev Biol. 2003;258:334–338
  4. Elvin JA, Yan C, Matzuk MM. Oocyte-expressed TGF-beta superfamily members in female fertility. Mol Cell Endocrinol. 2000;159:1–5
  5. Pepling ME, Spradling AC. Mouse ovarian germ cell cysts undergo programmed breakdown to form primordial follicles. Dev Biol. 2001;234:339–351
  6. Clark JM, Eddy EM. Fine structural observations on the origin and associations of primordial germ cells of the mouse. Dev Biol. 1975;47:136–155
  7. Donovan PJ, Stott D, Cairns LA, Heasman J, Wylie CC. Migratory and postmigratory mouse primordial germ cells behave differently in culture. Cell. 1986;44:831–838
  8. Anderson R, Copeland TK, Scholer H, Heasman J, Wylie C. The onset of germ cell migration in the mouse embryo. Mech Dev. 2000;91:61–68
  9. Pedersen T, Peters H. Proposal for a classification of oocytes and follicles in the mouse ovary. J Reprod Fertil. 1968;17:555–557
  10. Pangas SA, Choi Y, Ballow DJ, Zhao Y, Westphal H, Matzuk MM, et al. Oogenesis requires germ cell-specific transcriptional Sohlh1 and Lhx8. Proc Natl Acad Sci U S A. 2006;103:8090–8095
  11. Rajkovic A, Yan MSC, Klysik M, Matzuk M. Discovery of germ cell-specific transcripts by expressed sequence tag database analysis. Fertil Steril. 2001;76:550–554
  12. Suzumori N, Yan C, Matzuk MM, Rajkovic A. Nobox is a homeobox-encoding gene preferentially expressed in primordial and growing oocytes. Mech Dev. 2002;111:137–141
  13. Rajkovic A, Pangas SA, Ballow D, Suzumori N, Matzuk MM. Nobox deficiency disrupts early folliculogenesis and oocyte-specific gene expression. Science. 2004;305:1157–1159
  14. Choi Y, Qin Y, Berger MF, Ballow DJ, Bulyk ML, Rajkovic A. Microarray analyses of newborn mouse ovaries lacking Nobox. Biol Reprod. 2007;77:312–319
  15. Elvin JA, Yan C, Wang P, Nishimori K, Matzuk MM. Molecular characterization of the follicle defects in the growth differentiation factor-9-deficient ovary. Mol Endocrinol. 1999;13:1018–1034
  16. Pangas SA, Rademaker AW, Fishman DA, Woodruff TK. Localization of the activin signal transduction components in normal human ovarian follicles: implications for autocrine and paracrine signaling in the ovary. J Clin Endocrinol Metab. 2002;87:2644–2657

 S.P.K. has nothing to disclose. D.J.B. has nothing to disclose. Y.C. has nothing to disclose. A.R. has nothing to disclose.

 Supported by a National Institutes of Health grant (HD44858) and a March of Dimes Basil O'Connor Award (5-FY02-266) (both to A.R.).

 Presented as an oral presentation at the 63rd Annual Meeting of the American Society for Reproductive Medicine, October 13–17, 2007, Washington, DC.

PII: S0015-0282(08)01154-0

doi: 10.1016/j.fertnstert.2008.05.042

Fertility and Sterility
Volume 91, Issue 5, Supplement , Pages 2020-2024 , May 2009

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