The effect of surgical treatment for endometrioma on in vitro fertilization outcomes: a systematic review and meta-analysis
Received 26 March 2008; received in revised form 7 May 2008; accepted 15 May 2008. published online 11 August 2008.
Objective
To investigate the effect of surgical treatment of endometrioma on pregnancy rate and ovarian response to gonadotrophin stimulation in women undergoing IVF.
Design
A systematic review and meta-analysis.
Setting
Tertiary referral center for reproductive medicine.
Patient(s)
Subfertile women with endometrioma undergoing IVF.
Intervention(s)
Surgical removal of endometrioma or expectant management.
Main Outcome Measure(s)
Clinical pregnancy rate and ovarian response to gonadotrophins (number of gonadotrophin ampoules, peak E2 levels, number of oocytes retrieved, and number of embryos available for transfer).
Result(s)
A search of three electronic databases for articles published between January 1985 and November 2007 yielded 20 eligible studies. Meta-analysis was conducted for five studies that compared surgery vs. no treatment of endometrioma. There was no significant difference in clinical pregnancy rate between the treated and the untreated groups. Similarly, no significant difference was found between the two groups with regard to the outcome measures used to assess the response to controlled ovarian hyperstimulation with gonadotrophins.
Conclusion(s)
Collectively the available data in the literature show that surgical management of endometriomas has no significant effect on IVF pregnancy rates and ovarian response to stimulation compared with no treatment. Randomized controlled trials are needed before producing best-practice recommendations on this topic.
aDepartment of Obstetrics and Gynecology, Royal Lancaster Infirmary, Lancaster, United Kingdom
bDepartment of Obstetrics and Gynecology, Lancashire Teaching Hospitals, Preston, United Kingdom
cDepartment of Reproductive Medicine, St. Mary's Hospital, Central Manchester and Manchester Children's University Hospitals, Manchester, United Kingdom
Reprint requests: Luciano G. Nardo, M.D., Department of Reproductive Medicine, St. Mary's Hospital, Whitworth Park, Manchester M13 0JH, United Kingdom (FAX: 44-161-224-0957).
I.T. has nothing to disclose. M.K. has nothing to disclose. T.A.G. has nothing to disclose. L.G.N. has nothing to disclose.
ABSTRACT