Fertility and Sterility
Volume 92, Issue 1 , Pages 61-67 , July 2009

The impact of peritoneal fluid from healthy women and from women with endometriosis on sperm DNA and its relationship to the sperm deformity index

  • Gihan Mansour, M.D.

      Affiliations

    • Obstetrics and Gynecology and Women's Health Institute, Cleveland Clinic, Cleveland, Ohio
  • ,
  • Nabil Aziz, M.D.

      Affiliations

    • Liverpool Women's Hospital, Liverpool, United Kingdom
  • ,
  • Rakesh Sharma, Ph.D.

      Affiliations

    • Obstetrics and Gynecology and Women's Health Institute, Cleveland Clinic, Cleveland, Ohio
    • Glickman Urological and Kidney Institute, Center for Reproductive Medicine, Cleveland Clinic, Cleveland, Ohio
  • ,
  • Tommaso Falcone, M.D.

      Affiliations

    • Obstetrics and Gynecology and Women's Health Institute, Cleveland Clinic, Cleveland, Ohio
    • Glickman Urological and Kidney Institute, Center for Reproductive Medicine, Cleveland Clinic, Cleveland, Ohio
  • ,
  • Jeffery Goldberg, M.D.

      Affiliations

    • Obstetrics and Gynecology and Women's Health Institute, Cleveland Clinic, Cleveland, Ohio
  • ,
  • Ashok Agarwal, Ph.D., H.C.L.D.

      Affiliations

    • Obstetrics and Gynecology and Women's Health Institute, Cleveland Clinic, Cleveland, Ohio
    • Glickman Urological and Kidney Institute, Center for Reproductive Medicine, Cleveland Clinic, Cleveland, Ohio
    • Corresponding Author InformationReprint requests: Ashok Agarwal, Ph.D., H.C.L.D., Professor and Director, Center for Reproductive Medicine, Staff, Glickman Urological and Kidney Institute and Obstetrics/Gynecology and Women's Health Institute, Cleveland Clinic, 9500 Euclid Avenue, Desk A19.1, Cleveland, Ohio 44195 (FAX: 216-636-3118).

Received 31 March 2008 ,Revised 2 May 2008 ,Accepted 15 May 2008.

References 

  1. Missmer SA, Cramer DW. The epidemiology of endometriosis. Obstet Gynecol Clin North Am. 2003;30:1–19
  2. Eskenazi B, Warner ML. Epidemiology of endometriosis. Obstet Gynecol Clin North Am. 1997;24:235–258
  3. Hompes PG, Mijatovic V. Endometriosis: the way forward. Gynecol Endocrinol. 2007;23:5–12
  4. Practice Committee of the ASRM. Endometriosis and infertility. Fertil Steril. 2004;81:1441–1446
  5. Donnez J, Van Langendonckt A, Casanas-Roux F, Van Gossum JP, Pirard C, Jadoul P, et al. Current thinking on the pathogenesis of endometriosis. Gynecol Obstet Invest. 2002;54(Suppl 1):52–58discussion 9–62
  6. Gupta S, Agarwal A, Krajcir N, Alvarez JG. Role of oxidative stress in endometriosis. Reprod Biomed Online. 2006;13:126–134
  7. Bedaiwy MA, Falcone T. Laboratory testing for endometriosis. Clin Chim Acta. 2004;340:41–56
  8. Bedaiwy MA, Falcone T, Sharma RK, Goldberg JM, Attaran M, Nelson DR, et al. Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial. Hum Reprod. 2002;17:426–431
  9. Agarwal A, Sharma RK, Nallella KP, Thomas AJ, Alvarez JG, Sikka SC. Reactive oxygen species as an independent marker of male factor infertility. Fertil Steril. 2006;86:878–885
  10. Tremellen K. Oxidative stress and male infertility—a clinical perspective. Hum Reprod Update. 2008;14:243–258
  11. Irvine DS, Twigg JP, Gordon EL, Fulton N, Milne PA, Aitken RJ. DNA integrity in human spermatozoa: relationships with semen quality. J Androl. 2000;21:33–44
  12. Rosety M, Rosety I, Frias L, Rosety JM, Ordonez FJ, Rosety-Rodriguez M. Lipid peroxidation was associated to the impairment of the fertilizing capability of gilthead sperm exposed to surfactants. Histol Histopathol. 2007;22:869–872
  13. Chenoweth PJ. Influence of the male on embryo quality. Theriogenology. 2007;68:308–315
  14. Eisermann J, Gast MJ, Pineda J, Odem RR, Collins JL. Tumor necrosis factor in peritoneal fluid of women undergoing laparoscopic surgery. Fertil Steril. 1988;50:573–579
  15. Perdichizzi A, Nicoletti F, La Vignera S, Barone N, D'Agata R, Vicari E, et al. Effects of tumour necrosis factor-alpha on human sperm motility and apoptosis. J Clin Immunol. 2007;27:152–162
  16. Aziz N, Buchan I, Taylor C, Kingsland CR, Lewis-Jones I. The sperm deformity index: a reliable predictor of the outcome of oocyte fertilization in vitro. Fertil Steril. 1996;66:1000–1008
  17. Aziz N, Agarwal A, Lewis-Jones I, Sharma RK, Thomas AJ. Novel associations between specific sperm morphological defects and leukocytospermia. Fertil Steril. 2004;82:621–627
  18. Said TM, Aziz N, Sharma RK, Lewis-Jones I, Thomas AJ, Agarwal A. Novel association between sperm deformity index and oxidative stress–induced DNA damage in infertile male patients. Asian J Androl. 2005;7:121–126
  19. Aziz N, Said T, Paasch U, Agarwal A. The relationship between human sperm apoptosis, morphology and the sperm deformity index. Hum Reprod. 2007;22:1413–1419
  20. World Health Organization WHO. WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 4th ed.. Cambridge: Cambridge University Press; 1999;
  21. ASRM . Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril. 1997;67:817–821
  22. Eliasson R. standards for investigation of human semen. Andrologia. 1971;3:49–64
  23. Kruger TF, Acosta AA, Simmons KF, Swanson RJ, Matta JF, Oehninger S. Predictive value of abnormal sperm morphology in in vitro fertilization. Fertil Steril. 1988;49:112–117
  24. Suarez SS, Pacey AA. Sperm transport in the female reproductive tract. Hum Reprod Update. 2006;12:23–37
  25. Zeller JM, Henig I, Radwanska E, Dmowski WP. Enhancement of human monocyte and peritoneal macrophage chemiluminescence activities in women with endometriosis. Am J Reprod Immunol Microbiol. 1987;13:78–82
  26. Said TM, Agarwal A, Sharma RK, Thomas AJ, Sikka SC. Impact of sperm morphology on DNA damage caused by oxidative stress induced by beta-nicotinamide adenine dinucleotide phosphate. Fertil Steril. 2005;83:95–103
  27. Menezo YJ, Hazout A, Panteix G, Robert F, Rollet J, Cohen-Bacrie P, et al. Antioxidants to reduce sperm DNA fragmentation: an unexpected adverse effect. Reprod Biomed Online. 2007;14:418–421
  28. Aitken RJ, Krausz C. Oxidative stress, DNA damage and the Y chromosome. Reproduction (Camb). 2001;122:497–506
  29. Agarwal A, Gupta S, Sharma R. Oxidative stress and its implications in female infertility—a clinician's perspective. Reprod Biomed Online. 2005;11:641–650
  30. Donnelly ET, Steele EK, McClure N, Lewis SE. Assessment of DNA integrity and morphology of ejaculated spermatozoa from fertile and infertile men before and after cryopreservation. Hum Reprod. 2001;16:1191–1199
  31. Saleh RA, Agarwal A, Nelson DR, Nada EA, El-Tonsy MH, Alvarez JG, et al. Increased sperm nuclear DNA damage in normozoospermic infertile men: a prospective study. Fertil Steril. 2002;78:313–318
  32. Prefumo F, Semino C, Melioli G, Venturini PL. A defective expression of ICAM-1 (CD54) on secretory endometrial cells is associated with endometriosis. Immunol Lett. 2002;80:49–53
  33. Dmowski WP, Radwanska E, Binor Z, Rana N. Mild endometriosis and ovulatory dysfunction: effect of danazol treatment on success of ovulation induction. Fertil Steril. 1986;46:784–789
  34. Garrido N, Navarro J, Garcia-Velasco J, Remoh J, Pellice A, Simon C. The endometrium versus embryonic quality in endometriosis-related infertility. Hum Reprod Update. 2002;8:95–103
  35. Garrido N, Pellicer A, Remohi J, Simon C. Uterine and ovarian function in endometriosis. Semin Reprod Med. 2003;21:183–192
  36. Lebovic DI, Mueller MD, Taylor RN. Immunobiology of endometriosis. Fertil Steril. 2001;75:1–10
  37. Mori H, Sawairi M, Nakagawa M, Itoh N, Wada K, Tamaya T. Peritoneal fluid interleukin-1 beta and tumor necrosis factor in patients with benign gynecologic disease. Am J Reprod Immunol. 1991;26:62–67
  38. Gnessi L, Fabbri A, Spera G. Gonadal peptides as mediators of development and functional control of the testis: an integrated system with hormones and local environment. Endocr Rev. 1997;18:541–609
  39. Bullimore DW. Endometriosis is sustained by tumour necrosis factor-alpha. Med Hypotheses. 2003;60:84–88
  40. Iwabe T, Harada T, Terakawa N. Role of cytokines in endometriosis-associated infertility. Gynecol Obstet Invest. 2002;53(Suppl 1):19–25
  41. Buch JP, Kolon TF, Maulik N, Kreutzer DL, Das DK. Cytokines stimulate lipid membrane peroxidation of human sperm. Fertil Steril. 1994;62:186–188
  42. Curtin JF, Cotter TG. Live and let die: regulatory mechanisms in Fas-mediated apoptosis. Cell Signal. 2003;15:983–992
  43. Shanti A, Santanam N, Morales AJ, Parthasarathy S, Murphy AA. Autoantibodies to markers of oxidative stress are elevated in women with endometriosis. Fertil Steril. 1999;71:1115–1118
  44. Muratori M, Maggi M, Spinelli S, Filimberti E, Forti G, Baldi E. Spontaneous DNA fragmentation in swim-up selected human spermatozoa during long term incubation. J Androl. 2003;24:253–262
  45. Lewis-Jones I, Aziz N, Seshadri S, Douglas A, Howard P. Sperm chromosomal abnormalities are linked to sperm morphologic deformities. Fertil Steril. 2003;79:212–215
  46. Ollero M, Gil-Guzman E, Lopez MC, Sharma RK, Agarwal A, Larson K, et al. Characterization of subsets of human spermatozoa at different stages of maturation: implications in the diagnosis and treatment of male infertility. Hum Reprod. 2001;16:1912–1921

 G.M. has nothing to disclose. N.A. has nothing to disclose. R.S. has nothing to disclose. T.F. has nothing to disclose. J.G. has nothing to disclose. A.A. has nothing to disclose.

 Presented at the 63rd Annual meeting of the American Society of Reproductive Medicine, which was held in Washington, D.C., on October 13–17, 2007.

 Research support provided by the Department of Obstetrics and Gynecology and Research Programs Committee (RPC 2006-1035), Cleveland Clinic.

PII: S0015-0282(08)01159-X

doi: 10.1016/j.fertnstert.2008.05.048

Fertility and Sterility
Volume 92, Issue 1 , Pages 61-67 , July 2009