Fertility and Sterility
Volume 91, Issue 4, Supplement , Pages 1420-1423 , April 2009

Expressions of steroid receptors and Ki67 in first-trimester decidua and chorionic villi exposed to levonorgestrel used for emergency contraception

  • Chun-Xia Meng, M.D.

      Affiliations

    • Department of Woman and Child Health, Division of Obstetrics and Gynecology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    • The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
    • ,
  • Li-Nan Cheng, M.D.

      Affiliations

    • The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
    • ,
  • Parameswaran Grace Luther Lalitkumar, Ph.D.

      Affiliations

    • Department of Woman and Child Health, Division of Obstetrics and Gynecology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    • ,
  • Lin Zhang, M.D.

      Affiliations

    • The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
    • ,
  • Hui-Juan Zhang, M.D.

      Affiliations

    • The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
    • ,
  • Kristina Gemzell-Danielsson, M.D., Ph.D.

      Affiliations

    • Department of Woman and Child Health, Division of Obstetrics and Gynecology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    • Corresponding Author InformationReprint requests: Kristina Gemzell-Danielsson, M.D., Ph.D., WHO-Collaborating Center, C1:05, Karolinska University Hospital, 17176, Stockholm, Sweden (FAX: 46-8-51774314).

Received 1 February 2008 ,Revised 6 May 2008 ,Accepted 15 May 2008.

References 

  1. Croxatto HB, Fernandez SD. Emergency contraception—a human rights issue. Best Practice & Res. 2006;20:311–322
  2. von Hertzen H, Piaggio G, Ding J, Chen J, Song S, Bartfai G, et al. Low dose mifepristone and two regimens of levonorgestrel for emergency contraception: a WHO multicentre randomised trial. Lancet. 2002;360:1803–1810
  3. Gemzell-Danielsson K, Marions L. Mechanisms of action of mifepristone and levonorgestrel when used for emergency contraception. Hum Reprod Update. 2004;10:341–348
  4. Vermeulen-Meiners C, Poortman J, Nabuurs M, Thijssen JH. The endogenous concentration and subcellular distribution of androgens in normal human premenopausal endometrium, myometrium and vagina. Gynecol Endocrinol. 1988;2:121–130
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  6. Achache H, Revel A. Endometrial receptivity markers, the journey to successful embryo implantation. Hum Reprod Update. 2006;12:731–746
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  8. Marx L, Arck P, Kapp M, Kieslich C, Dietl J. Leukocyte populations, hormone receptors and apoptosis in eutopic and ectopic first trimester human pregnancies. Hum Reprod (Oxford, Engl). 1999;14:1111–1117
  9. Taylor LJ, Jackson TL, Reid JG, Duffy SR. The differential expression of oestrogen receptors, progesterone receptors, Bcl-2 and Ki67 in endometrial polyps. BJOG. 2003;110:794–798
  10. Mylonas I, Jeschke U, Shabani N, Kuhn C, Balle A, Kriegel S, et al. Immunohistochemical analysis of estrogen receptor alpha, estrogen receptor beta and progesterone receptor in normal human endometrium. Acta Histochem. 2004;106:245–252
  11. Lenton EA, Landgren BM, Sexton L. Normal variation in the length of the luteal phase of the menstrual cycle: identification of the short luteal phase. BJOG. 1984;91:685–689
  12. Milne SA, Henderson TA, Kelly RW, Saunders PT, Baird DT, Critchley HO. Leukocyte populations and steroid receptor expression in human first-trimester decidua; regulation by antiprogestin and prostaglandin E analog. J Clin Endocrinol Metab. 2005;90:4315–4321
  13. Wu WX, Brooks J, Millar MR, Ledger WL, Glasier AF, McNeilly AS. Immunolocalization of oestrogen and progesterone receptors in the human decidua in relation to prolactin production. Hum Reprod (Oxford, Engl). 1993;8:1129–1135
  14. Horie K, Takakura K, Imai K, Liao S, Mori T. Immunohistochemical localization of androgen receptor in the human endometrium, decidua, placenta and pathological conditions of the endometrium. Hum Reprod (Oxford, Engl). 1992;7:1461–1466
  15. Perrot-Applanat M, Groyer-Picard MT, Garcia E, Lorenzo F, Milgrom E. Immunocytochemical demonstration of estrogen and progesterone receptors in muscle cells of uterine arteries in rabbits and humans. Endocrinology. 1988;123:1511–1519
  16. Lalitkumar PG, Lalitkumar S, Meng CX, Stavreus-Evers A, Hambiliki F, Bentin-Ley U, et al. Mifepristone, but not levonorgestrel, inhibits human blastocyst attachment to an in vitro endometrial three-dimensional cell culture model. Hum Reprod (Oxford, Engl). 2007;22:3031–3037

 C.-X.M. has nothing to disclose. L.-N.C. has nothing to disclose. P.G.L.L.K. has nothing to disclose. L.Z. has nothing to disclose. H.-J.Z. has nothing to disclose. K.G.-D. has nothing to disclose.

 Li-Nan Cheng and Kristina Gemzell-Danielsson contributed equally to the study.

 Supported by Chinese Committee of Population and Family Planning (2004BA709B11) and Swedish Medical Research Council (K2007-54X-14212-06-3) and Stockholm City County, Karolinska Institutet (ALF).

PII: S0015-0282(08)01165-5

doi: 10.1016/j.fertnstert.2008.05.058

Fertility and Sterility
Volume 91, Issue 4, Supplement , Pages 1420-1423 , April 2009

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