Fertility and Sterility
Volume 91, Issue 4, Supplement , Pages 1424-1426 , April 2009

Cyclin and protamine as prognostic molecular marker for testicular sperm extraction in patients with azoospermia

  • Takahiro Haraguchi, M.D.
    • ,
  • Tomomoto Ishikawa, M.D., Ph.D.

      Affiliations

    • Corresponding Author InformationReprint requests: Tomomoto Ishikawa, M.D., Ph.D., Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe 650-0017, Japan (FAX: 81-78-382-6169).
    • ,
  • Kohei Yamaguchi, M.D.
    • ,
  • Masato Fujisawa, M.D., Ph.D.

Received 21 January 2008 ,Revised 19 May 2008 ,Accepted 20 May 2008.

References 

  1. Wolgemuth DJ, Laurion E, Lele KM. Regulation of the mitotic and meiotic cell cycles in the male germ line. Rec Prog Horm Res. 2002;57:75–101
  2. Muller C, Readhead C, Diederichs S, Idos G, Yang R, Tidow N, et al. Methylation of the cyclin A1 promoter correlates with gene silencing in somatic cell lines, while tissue-specific expression of cyclin A1 is methylation independent. Mol Cell Biol. 2000;20:3316–3329
  3. Lin YM, Teng YN, Chung CL, Tsai WC, Lin YH, Lin JSN, et al. Decreased mRNA transcripts of M-phase promoting factor and its regulators in testes of infertile men. Hum Reprod. 2006;21:138–144
  4. McKay DJ, Renaux BS, Dixon GH. The amino acid sequence of human sperm protamine P1. Biosci Rep. 1985;5:383–391
  5. Domenjoud L, Fronia C, Uhde F, Engel W. Sequence of human protamine 2 cDNA. Nucleic Acids Res. 1988;16:7733
  6. Schrader M, Muller-Tidow C, Ravnik S, Muller M, Schulze W, Diederichs S, et al. Cyclin A1 and gametogenesis in fertile and infertile patients: a potential new molecular diagnostic marker. Hum Reprod. 2002;17:2338–2343
  7. Steger K, Fink L, Failing K, Bohle RM, Kliesch S, Weidner W, et al. Decreased protamine-1 transcript levels in testes from infertile men. Mol Hum Reprod. 2003;9:331–336
  8. Cho C, Willis WD, Goulding EH, Jung-Ha H, Choi YC, Hecht NB, et al. Haploinsufficiency of protamine-1 or -2 causes infertility in mice. Nat Genet. 2001;28:82–86
  9. Brandeis M, Rosewell I, Carrington M, Crompton T, Jacobs MA, Kirk J, et al. Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero. Proc Natl Acad Sci USA. 1998;95:4344–4349
  10. Weikert S, Schrader M, Muller M, Schulze W, Krause H, Miller K. Expression levels of the inhibitor of apoptosis survivin in testes of patients with normal spermatogenesis and spermatogenic failure. Fertil Steril. 2005;83:1100–1105
  11. Lin YM, Kuo PL, Lin YH, Teng YN, Lin JSN. Messenger RNA transcripts of the meiotic regulator BOULE in the testis of azoospermic men and their application in predicting the success of sperm retrieval. Hum Reprod. 2005;20:782–788

 T.H. has nothing to disclose. T.I. has nothing to disclose. K.Y. has nothing to disclose. M.F. has nothing to disclose.

PII: S0015-0282(08)01185-0

doi: 10.1016/j.fertnstert.2008.05.072

Fertility and Sterility
Volume 91, Issue 4, Supplement , Pages 1424-1426 , April 2009

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