Fertility and Sterility
Volume 91, Issue 5, Supplement , Pages 2247-2252 , May 2009

The effect of vascular endothelial growth factor on spermatogenesis and apoptosis in experimentally varicocele-induced adolescent rats

  • Mesut Tek, M.D.

      Affiliations

    • Department of Urology, University of Mersin School of Medicine, Mersin, Turkey
    • ,
  • Selahittin Çayan, M.D.

      Affiliations

    • Department of Urology, University of Mersin School of Medicine, Mersin, Turkey
    • Corresponding Author InformationReprint requests: Selahittin Çayan, M.D., Associate Professor of Urology, University of Mersin School of Medicine, Department of Urology, 33079-Mersin, Turkey (FAX: 90-324-337-4311).
    • ,
  • Nejat Yılmaz, M.D., Ph.D.

      Affiliations

    • Department of Histology and Embryology, University of Mersin School of Medicine, Mersin, Turkey
    • ,
  • İzzet Oğuz, M.D.

      Affiliations

    • Department of Histology and Embryology, University of Mersin School of Medicine, Mersin, Turkey
    • ,
  • Erkan Erdem, M.D.

      Affiliations

    • Department of Urology, University of Mersin School of Medicine, Mersin, Turkey
    • ,
  • Erdem Akbay, M.D.

      Affiliations

    • Department of Urology, University of Mersin School of Medicine, Mersin, Turkey

Received 23 March 2008 ,Revised 10 May 2008 ,Accepted 5 June 2008.

References 

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  2. Cayan S, Kadioğlu TC, Tefekli A, Kadioğlu A, Tellaloğlu S. Comparison of results and complications of high ligation surgery and microsurgical high inguinal varicocelectomy in the treatment of varicocele. Urology. 2000;55:750–754
  3. Marmar JL, Agarwal A, Prabakaran S, Agarwal R, Short RA, Benoff S, et al. Reassessing the value of varicocelectomy as a treatment for male subfertility with a new meta-analysis. Fertil Steril. 2007;88:639–648
  4. Fretz PC, Sandlow JI. Varicocele: current concepts in pathophysiology, diagnosis, and treatment. Urol Clin North Am. 2002;29:921–937
  5. Kilinc F, Kayaselcuk F, Aygun C, Guvel S, Egilmez T, Ozkardes H. Experimental varicocele induces hypoxia inducible factor-1 alpha, vascular endothelial growth factor expression and angiogenesis in the rat testis. J Urol. 2004;172:1188–1191
  6. Lee JD, Jeng SY, Lee TH. Increased expression of hypoxia-inducible factor-1 alpha in the internal spermatic vein of patients with varicocele. J Urol. 2006;175:1045–1048
  7. Fazlioglu A, Yılmaz I, Mete O, Kurtulus F, Parlakilic O, Guctas O, et al. The effect of varicocele repair on experimental varicocele induced testicular germ cell apoptosis. J Androl. 2008;29:29–34
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  14. Nagler HM, Luntz RK, Martinis FG. Varicocele. In:  Lipschultz LI,  Howards SS editor. Infertility in the Male. 3 ed. St. Louis: Mosby Year Book; 1997;p. 336–359
  15. Tulloch WS. A consideration of sterility factors in the light of subsequent pregnancies. Subfertility in the male. Trans Edinburg Obstet Soc. 1952;59:29
  16. Cayan S, Lee D, Black LD, Reijo Pera RA, Turek PJ. Response to varicocelectomy in oligospermic men with and without defined genetic infertility. Urology. 2001;57:530–535
  17. Hikim AP, Wang C, Lue Y, Johnson L, Wang XH, Swerdloff RS. Spontaneous germ cell apoptosis in humans: evidence for ethnic differences in the susceptibility of germ cells to programmed cell death. J Clin Endocrinol Metab. 1998;83:152–156
  18. Kerr JFR, Wyllie AH, Currie AR. Apoptosis. A basic biological phenomenon with wide ranging implications in tissue kinetics. Br J Cancer. 1972;26:239–245
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 M.T. has nothing to disclose. S.Ç. has nothing to disclose. N.Y. has nothing to disclose. I.O. has nothing to disclose. E.E. has nothing to disclose. E.A. has nothing to disclose.

PII: S0015-0282(08)01302-2

doi: 10.1016/j.fertnstert.2008.06.008

Fertility and Sterility
Volume 91, Issue 5, Supplement , Pages 2247-2252 , May 2009

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