Fertility and Sterility
Volume 92, Issue 2 , Pages 417-427, August 2009

Effects of cancer treatment on ovarian function

  • Jaymeson S. Stroud, M.D.

      Affiliations

    • Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri
    • ,
  • David Mutch, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, Missouri
    • Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri
    • ,
  • Janet Rader, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, Missouri
    • Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri
    • ,
  • Matt Powell, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, Missouri
    • Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri
    • ,
  • Premal H. Thaker, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, Missouri
    • Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri
    • ,
  • Perry W. Grigsby, M.D.

      Affiliations

    • Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri
    • Department of Radiology, Division of Nuclear Medicine, Washington University School of Medicine, St. Louis, Missouri
    • Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, Missouri
    • Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri
    • Corresponding Author InformationReprint requests: Perry W. Grigsby, M.D., Department of Radiation Oncology, Box 8224, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4921 Parkview Place, Lower Level, St. Louis, MO 63110 (FAX: 314-747-9557).

Received 7 March 2008; received in revised form 23 June 2008; accepted 9 July 2008. published online 09 September 2008.

Causes of primary ovarian failure are reviewed, focusing specifically on cancer treatment-related modalities. Strategies and future directions for protection of the ovaries during cancer therapy, including ovarian transposition, and conformal radiation techniques are presented.

Key Words: Ovarian failure, cancer treatment, radiation toxicity

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 J.S.S. has nothing to disclose. D.M. has nothing to disclose. J.R. has nothing to disclose. M.P. has nothing to disclose. P.H.T. has nothing to disclose. P.W.G. has nothing to disclose.

PII: S0015-0282(08)01489-1

doi:10.1016/j.fertnstert.2008.07.1714

Fertility and Sterility
Volume 92, Issue 2 , Pages 417-427, August 2009

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