Fertility and Sterility
Volume 92, Issue 3 , Pages 913-917 , September 2009

Live birth sex ratios are not influenced by blastocyst-stage embryo transfer

  • John M. Csokmay, M.D.

      Affiliations

    • National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland
    • ,
  • Micah J. Hill, D.O.

      Affiliations

    • Blanchfield Army Community Hospital, Ft. Campbell, Kentucky
    • ,
  • Frank V. Cioppettini

      Affiliations

    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • ,
  • Kathleen A. Miller, BS

      Affiliations

    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • ,
  • Richard T. Scott Jr., M.D., HCLD

      Affiliations

    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • ,
  • John L. Frattarelli, M.D.

      Affiliations

    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • Corresponding Author InformationReprint requests: John L. Frattarelli, M.D., Reproductive Medicine Associates of New Jersey, 111 Madison Avenue, Suite 100, Morristown, NJ 07960 (FAX: 732-537-0134).

Received 29 February 2008 ,Revised 1 June 2008 ,Accepted 10 July 2008.

References 

  1. Gardner DK, Schoolcraft WB, Wagley L, Schlenker T, Stevens J, Hesla J. A prospective randomized trial of blastocyst culture and transfer in in-vitro fertilization. Hum Reprod. 1998;13:3434–3440
  2. Papanikolaou EG, Camus M, Kolibianakis EM, Van Landuyt L, Van Steirteghem A, Devroey P. In vitro fertilization with single blastocyst-stage versus single cleavage-stage embryos. N Engl J Med. 2006;354:1139–1146
  3. Blake D, Farquhar CM, Johnson N, Proctor M. Cleavage stage versus blastocyst stage embryo transfer in assisted conception. Cochrane Database Syst Rev. 2005;19:CD002118
  4. Frattarelli JL, Leondires MP, McKeeby JL, Miller BT, Segars JH. Blastocyst transfer decreases multiple pregnancy rates: a prospective randomized study. Fertil Steril. 2003;79:228–230
  5. Avery B, Jørgensen CB, Madison V, Greve T. Morphological development and sex of bovine in vitro-fertilized embryos. Mol Reprod Dev. 1992;32:265–270
  6. Valdivia RP, Kunieda T, Azuma S, Toyoda Y. PCR sexing and developmental rate differences in preimplantation mouse embryos fertilized and cultured in vitro. Mol Reprod Dev. 1993;35:121–126
  7. Cassar G, King WA, King GJ. Influence of sex on early growth of pig conceptuses. J Reprod Fertil. 1994;101:317–320
  8. Ray PF, Conaghan J, Winston RM, Handyside AH. Increased number of cells and metabolic activity in male human preimplantation embryos following in vitro fertilization. J Reprod Fertil. 1995;104:165–171
  9. Tarín JJ, Bernabeu R, Baviera A, Bonada M, Cano A. Sex selection may be inadvertently performed in in-vitro fertilization-embryo transfer programmes. Hum Reprod. 1995;10:2992–2998
  10. Ng E, Claman P, Léveillé MC, Tanphaichitr N, Compitak K, Suwajanakorn S, et al. Sex ratio of babies is unchanged after transfer of fast- versus slow-cleaving embryos. J Assist Reprod Genet. 1995;12:566–568
  11. Kausche A, Jones GM, Trounson AO, Figueiredo F, MacLachlan V, Lolatgis N. Sex ratio and birth weights of infants born as a result of blastocyst transfers compared with early cleavage stage embryo transfers. Fertil Steril. 2001;76:688–693
  12. Schwärzler P, Zech H, Auer M, Pfau K, Göbel G, Vanderzwalmen P, et al. Pregnancy outcome after blastocyst transfer as compared with early cleavage stage embryo transfer. Hum Reprod. 2004;19:2097–2102
  13. Milki AA, Jun SH, Hinckley MD, Westphal LW, Giudice LC, Behr B. Comparison of the sex ratio with blastocyst transfer and cleavage stage transfer. J Assist Reprod Genet. 2003;20:323–326
  14. Luna M, Duke M, Copperman A, Grunfeld L, Sandler B, Barritt J. Blastocyst embryo transfer is associated with a sex-ratio imbalance in favor of male offspring. Fertil Steril. 2007;87:519–523
  15. Ménézo YJ, Chouteau J, Torelló MJ, Girard A, Veiga A. Birth weight and sex ratio after transfer at the blastocyst stage in humans. Fertil Steril. 1999;72:221–224
  16. Richter KS, Anderson M, Osborn BH. Selection for faster development does not bias sex ratios resulting from blastocyst embryo transfer. Reprod Biomed Online. 2006;12:460–465

 J.M.C. has nothing to disclose. M.J.H. has nothing to disclose. F.V.C. has nothing to disclose. K.A.M. has nothing to disclose. R.T.S. has nothing to disclose. J.L.F. has nothing to disclose.

PII: S0015-0282(08)03262-7

doi: 10.1016/j.fertnstert.2008.07.1741

Fertility and Sterility
Volume 92, Issue 3 , Pages 913-917 , September 2009

Article Tools