Fertility and Sterility
Volume 92, Issue 4 , Pages 1297-1301 , October 2009

Natural-cycle in vitro fertilization in poor responder patients: a survey of 500 consecutive cycles

  • Mauro Schimberni, M.D.

      Affiliations

    • Bioroma Centro di Riproduzione Assistita Casa di Cura “Paideia”, Rome, Italy
    • ,
  • Francesco Morgia, B.S.

      Affiliations

    • Bioroma Centro di Riproduzione Assistita Casa di Cura “Paideia”, Rome, Italy
    • ,
  • Julio Colabianchi, M.D.

      Affiliations

    • Bioroma Centro di Riproduzione Assistita Casa di Cura “Paideia”, Rome, Italy
    • ,
  • Annalise Giallonardo, M.D.

      Affiliations

    • Bioroma Centro di Riproduzione Assistita Casa di Cura “Paideia”, Rome, Italy
    • ,
  • Claudio Piscitelli, M.D.

      Affiliations

    • Bioroma Centro di Riproduzione Assistita Casa di Cura “Paideia”, Rome, Italy
    • ,
  • Pierluigi Giannini, M.D.

      Affiliations

    • Bioroma Centro di Riproduzione Assistita Casa di Cura “Paideia”, Rome, Italy
    • ,
  • Monica Montigiani, B.S.

      Affiliations

    • Bioroma Centro di Riproduzione Assistita Casa di Cura “Paideia”, Rome, Italy
    • ,
  • Marco Sbracia, M.D.

      Affiliations

    • Center for Endocrinology and Reproductive Medicine (CERM), Rome, Italy
    • Corresponding Author InformationReprint requests: Marco Sbracia, M.D., Center Endocrinology Reproductive Medicine (CERM), Via Carlo Porta 10, 00153 Rome, Italy (FAX: 39-06-5880096).

Received 2 April 2008 ,Revised 16 July 2008 ,Accepted 25 July 2008.

References 

  1. Bassil S, Godin PA, Donnez J. Outcome of in-vitro fertilization through natural cycles in poor responders. Hum Reprod. 1999;14:1262–1265
  2. Rongieres-Bertrand C, Olivennes F, Righini C, Fanchin R, Taieb J, Hamamah S, et al. Revival of the natural cycles in in-vitro fertilization with the use of a new gonadotrophin-releasing hormone antagonist (Cetrorelix): a pilot study with minimal stimulation. Hum Reprod. 1999;14:683–688
  3. Janssens RM, Lambalk CB, Vermeiden JP, Schats R, Schoemaker J. In-vitro fertilization in a spontaneous cycle: easy, cheap and realistic. Hum Reprod. 2000;15:314–318
  4. Nargund G, Waterstone J, Bland J, Philips Z, Parsons J, Campbell S. Cumulative conception and live birth rates in natural (unstimulated) IVF cycles. Hum Reprod. 2001;16:259–262
  5. Ng EH, Chui DK, Tang OS, Lau EY, Yeung WS, Chung HP. In vitro fertilization and embryo transfer during natural cycles. J Reprod Med. 2001;46:95–99
  6. Omland AK, Fedorcsak P, Storeng R, Dale PO, Abyholm T, Tanbo T. Natural cycle IVF in unexplained, endometriosis-associated and tubal factor infertility. Hum Reprod. 2001;16:2587–2592
  7. Pelinck MJ, Hoek A, Simons AH, Heineman MJ. Efficacy of natural cycle IVF: a review of the literature. Hum Reprod Update. 2002;8:129–139
  8. Pelinck MJ, Vogel NE, Hoek A, Arts EG, Simons AH, Heineman MJ. Minimal stimulation IVF with late follicular phase administration of the GnRH antagonist cetrorelix and concomitant substitution with recombinant FSH: a pilot study. Hum Reprod. 2005;20:642–648
  9. Pelinck MJ, Vogel NE, Hoek A, Simons AH, Arts EG, Mochtar MH, et al. Cumulative pregnancy rates after three cycles of minimal stimulation IVF and results according to subfertility diagnosis: a multicentre cohort study. Hum Reprod. 2006;21:2375–2383
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  11. Kolibianakis E, Zikopoulos K, Camus M, Tournaye H, Van Steirteghem A, Devroey P. Modified natural cycle for IVF does not offer a realistic chance of parenthood in poor responders with high day 3 FSH levels, as a last resort prior to oocyte donation. Hum Reprod. 2004;19:2545–2549
  12. Hanoch J, Lavy Y, Holzer H, Hurwitz A, Simon A, Revel A, et al. Young low responders protected from untoward effects of reduced ovarian response. Fertil Steril. 1998;69:1001–1004
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  14. Pellicer A, Ballester MJ, Serrano MD, Mir A, Serra-Serra V, Remohi J, et al. Aetiological factors involved in the low response to gonadotrophins in infertile women with normal basal serum follicle stimulating hormone levels. Hum Reprod. 1994;9:806–811
  15. Jacobs SL, Metzger DA, Dodson WC, Haney AF. Effect of age on response to human menopausal gonadotropin stimulation. J Clin Endocrinol Metab. 1990;71:1525–1530
  16. Karande V, Gleicher N. The diameter of the proximal tube—large enough for a single sperm or do you need more?. Fertil Steril. 1999;72:950–951
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  18. Janssens RM, Lambalk CB, Schats R, Schoemaker J. Successful in-vitro fertilization in a natural cycle after four previously failed attempts in stimulated cycles: case report. Hum Reprod. 1999;14:2497–2498
  19. Morgia F, Sbracia M, Schimberni M, Giallonardo A, Piscitelli C, Giannini P, et al. A controlled trial of natural cycle versus microdose gonadotropin releasing hormone analog flare cycles in poor responders undergoing in vitro fertilization. Fertil Steril. 2004;81:1542–1547
  20. van Rooij IAJ, Bancsi LF, Broekmans FJ, Looman CW, Habberna JD, te Velde ER. Women older than 40 years of age and those with elevated follicle-stimulating hormone levels differ in poor response rate and embryo quality in in vitro fertilization. Fertil Steril. 2003;79:482–488
  21. Surrey ES, Schoolcraft WB. Evaluating strategies for improving ovarian response of the poor responder undergoing assisted reproductive techniques. Fertil Steril. 2000;73:667–676
  22. Palermo G, Joris H, Devroey P, Van Steirteghem AC. Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte. Lancet. 1992;340:17–18
  23. Veeck LL. Fertilization and early embryonic development. Curr Opin Obstet Gynecol. 1992;4:702–711
  24. Mahutte NG, Arici A. Role of gonadotropin-releasing hormone antagonists in poor responders. Fertil Steril. 2007;87:241–249
  25. Daya S, Gunby J, Hughes EG, Collins JA, Sagle MA, YoungLai EV. Natural cycles for in-vitro fertilization: cost-effectiveness analysis and factors influencing outcome. Hum Reprod. 1995;10:1719–1724

 M.S. has nothing to disclose. F.M. has nothing to disclose. J.C. has nothing to disclose. A.G. has nothing to disclose. C.P. has nothing to disclose. P.G. has nothing to disclose. M.M. has nothing to disclose. M.S. has nothing to disclose.

PII: S0015-0282(08)03294-9

doi: 10.1016/j.fertnstert.2008.07.1765

Fertility and Sterility
Volume 92, Issue 4 , Pages 1297-1301 , October 2009

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