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Fertility and Sterility
Volume 91, Issue 1
, Pages 1-17
, January 2009
Strategies to reduce multiple pregnancies due to ovulation stimulation
References
- . Multiple pregnancies following ovulation induction. Fertil Steril. 1981;35:105–123
- . The relative contribution of assisted reproductive technologies and ovulation induction to multiple births in the United States 5 years after the Society for Assisted Reproductive Technology/American Society for Reproductive Medicine recommendation to limit the number of embryos transferred. Fertil Steril. 2007;88:1554–1561
- Spontaneous reduction of multiple pregnancy: incidence and effect on outcome. Am J Obstet Gynecol. 2002;186:77–83
- Luke B, Brown MB, Maternal morbidity and infant death in twin vs triplet and quadruplet pregnancies. Am J Obstet Gynecol 2098;198:401–3.
- . Multiple gestation and infertility treatment: registration, reflection and reaction—the Belgian Project. Hum Reprod Update. 2005;11:3–14
- . Perinatal outcomes of singleton and multiple births in the United States, 1995–98. In: Blickstein I, Keith LG editor. Multiple pregnancy: epidemiology, gestation, and perinatal outcome. 2nd ed.. London and New York: Taylor and Francis; 2005;p. 3–11
- . Guidelines on number of embryos transferred. A practice committee report. Birmingham, AL: American Society for Reproductive Medicine; 1998;
- . Guidelines on number of embryos transferred. Revised and amended November 1999, a practice committee report. Birmingham, AL: American Society for Reproductive Medicine; 1999;
- . Reducing the risk of high-order multiple pregnancy after ovarian induction with gonadotropins. N Engl J Med. 2000;343:2–7
- . Multiple pregnancy associated with infertility therapy: educational Bulletin. Fertil Steril. 2006;86(Suppl 4):S106–S110
- . Multiple births: how are we doing?. Fertil Steril. 2003;79:17–21
- . A year of inaction on high-order multiple pregnancies due to ovulation induction. Fertil Steril. 2003;79:14–16
- . Practice guidelines cannot be justifies in the absence of sufficient evidence: inaction is far more appropriate than indefensible action. Fertil Steril. 2003;79:22–24
- . Practice bulletin no. 34: management of infertility caused by ovulatory dysfunction. Obstet Gynecol. 2002;99:347–358
- . Evidence-based clinical guidelines. The management of infertility in secondary care. London: RCOG Press; 1998;
- . Multiple birth resulting from ovarian stimulation for infertility treatment. Lancet. 2005;365:1807–1816
- . Is controlled ovarian stimulation in intrauterine insemination an acceptable therapy in couples with unexplained nonconception in the perspective of multiple pregnancies?. Hum Reprod. 2006;21:701–704
- . Further clinical experience with clomiphene citrate. Fertil Steril. 1968;19:616–622
- . Pergonal (menotropins): a summary of clinical experience in the induction of ovulation and pregnancy. Fertil Steril. 1970;21:844–853
- . Maintenance of certification. ABOG Diplomate. 2005;31:1–7
- . In vitro fertilization/embryo transfer in the United States: 1985–1986 results from the National IVF-ET Registry. Fertil Steril. 1988;49:212–215
- . 2004 assisted reproductive technecology society rates. Atlanta, GA: Department of Health and Human Services, Centers for Disease Control and Prevention; 2006;
- . Perganol (menotropins for injection USP). [package insert] Randolf, MA: Serono Laboratories; 1969;
- . In vitro sperm capacitation and transcervical intrauterine insemination for the treatment of refractory infertility: phase I. Fertil Steril. 1984;41:260–264
- . Superovulation with intrauterine insemination in the treatment of infertility: a possible alternative to gamete intrafallopian transfer and in vitro fertilization. Fertil Steril. 1987;48:441–445
- . Risk factors for high-order multiple implantation after ovarian induction with gonadotropins: evidence from a large series of 1878 consecutive pregnancies in a single center. Hum Reprod. 2001;16:2124–2129
- . The study of induction of ovulation with menotropins: analysis of results of 1897 treatment cycles. Fertil Steril. 1978;30:538–544
- . What is the most relevant standard of success in assisted reproduction? No single outcome measure is satisfactory when evaluating success in assisted reproduction; both twin births and singleton births should be counted as successes. Hum Reprod. 2004;19:783–787
- . Preterm delivery: a review of the evidence-based literature. In: Blickstein I, Keith LG editor. Multiple pregnancy: epidemiology, gestation, and perinatal outcome. 2nd ed.. London and New York: Taylor and Francis; 2005;p. 626–630
- The relationships among psychosocial profile, maternal size, and smoking in predicting fetal growth retardation. Obstet Gynecol. 1992;80:262–267
- Prediction of preterm delivery in twins by cervical assessment at 23 weeks. Ultrasound Obstet Gynecol. 2001;17:7–10
- . Risk for one or two very low birth weight twins: a population study. Obstet Gynecol. 2000;96:400–402
- . Maternal morbidity and obstetric complications in triplet pregnancies and quadruplet and higher-order pregnancies. Am J Obstet Gynecol. 2004;191:254–258
- . Preventing preterm birth in twins and triplets. In: Blickstein I, Keith LG editor. Multiple pregnancy: epidemiology, gestation, and perinatal outcome. 2nd ed.. London and New York: Taylor and Francis; 2005;p. 631–639
- . Social groups and prevention of preterm births in a population of twin mothers. J Perinat Med. 1996;24:669–676
- . Effect of maternal height on gestational age and birth weight in nulliparous mothers of triplets with a normal pregravid body mass index. J Reprod Med. 2003;48:335–338
- . The likelihood of adverse outcomes in triplet pregnancies estimated by pre-gravid maternal characteristics. Fertil Steril. 2004;81:1079–1082
- . Factors responsible for multiple pregnancies after ovarian induction and intrauterine insemination with gonadotropins. J Assist Reprod Genet. 1996;13:663–668
- . Risk factors for high-order multiple pregnancy and multiple birth after controlled ovarian hyperstimulation: results of 4,062 intrauterine insemination cycles. Fertil Steril. 2005;83:671–683
- . Relationship of follicle numbers and estradiol concentrations to multiple implantation of 3608 intrauterine insemination cycles. Fertil Steril. 2001;75:69–78
- . Multiple gestation is associated with the use of high sperm numbers in the intrauterine insemination in women undergoing gonadotropin induction. Fertil Steril. 1988;49:607–610
- . Risk factors for multiple gestation in women undergoing intrauterine insemination with ovarian insemination. Fertil Steril. 1999;72:613–618
- . Treatment of anovulatory infertility: the problem of multiple pregnancy. Hum Reprod. 1996;11:429–434
- . A randomized controlled trial of three low-dose gonadotropins protocols for unexplained infertility. Hum Reprod. 1998;13:1527–1531
- . Cumulative pregnancy rates in couples with anovulatory infertility compared with unexplained infertility in an ovulation induction program. Hum Reprod. 1997;12:1939–1944
- . Intrauterine insemination and controlled ovarian hyperinduction in cycles before GIFT. Hum Reprod. 1989;4:918–920
- . Clomiphene citrate intrauterine insemination (IUI) before gonadotropin IUI affects the pregnancy rate and high order multiple pregnancy. Fertil Steril. 2004;81:545–550
- . Effect of diagnosis, age, sperm quality, and number of preovulatory follicles on the outcome of multiple cycles of clomiphene citrate–intrauterine insemination. Fertil Steril. 2002;78:1088–1095
- The safety and effectiveness of stepwise and low-dose administration of follicle stimulating hormone in WHO group II anovulatory infertile women: evidence from a large multicenter study in Spain. J Assist Reprod Genet. 1996;13:551–556
- Ovulation induction with a starting dose of 50 IU of recombinant follicle stimulating hormone in WHO group II anovulatory women: the IO-50 study, a prospective, observational, multicentre, open trial. BJOG. 2003;110:1072–1077
- . Risk of multiple pregnancy when infertility is treated with ovulation induction by gonadotropins. Fertil Steril. 2003;80:664–665
- Low dose recombinant FSH treatment may reduce multiple gestations caused by controlled ovarian hyperinduction and intrauterine insemination. BJOG. 2004;111:1277–1282
- . Preventing high-order multiple pregnancies during controlled ovarian hyperinduction and intrauterine insemination: 3 years' experience using a low-dose recombinant follicle-stimulating hormone and gonadotropin-releasing hormone antagonists. Fertil Steril. 2006;85:619–14
- . Relationship of clomiphene dose and patient weight to successful treatment. Hum. Reprod. 1997;12:449–453
- . Evaluation of predictive factors for multiple pregnancies during gonadotropin-IUI treatment. J Assist Reprod Genet. 1997;14:88–91
- . Relationship of follicle number and other factors to fecundability and multiple pregnancies in clomiphene citrate induced intrauterine insemination cycles. Fertil Steril. 1992;57:613–619
- . Manipulation of human ovarian function: physiological concepts and clinical consequences. Endocr Rev. 1997;18:71–106
- . Treating infertility: controlled ovarian hyperinduction using human menopausal gonadotropin in combination with intrauterine insemination. J Reprod Med. 1996;41:658–664
- External validation of a prediction model for an ongoing pregnancy after intrauterine insemination. Fertil Steril. 2007;88:425–430
- . Prognostic indicators for intrauterine insemination (IUI): statistical model for IUI success. Hum Reprod. 1996;11:1892–1896
- . Is twin pregnancy necessarily an adverse outcome of assisted reproductive technologies?. Hum Reprod. 2006;21:2736–2738
- . Guidelines on number of embryos transferred. Fertil Steril. 2006;86(Suppl 4):S51–S52
- . Metformin in polycystic ovary syndrome:systematic review and meta-analysis. BMJ. 2003;327:951–953
- Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome. N Engl J Med. 2007;356:551–566
- . Efficacy of treatment for unexplained infertility. Fertil Steril. 1998;70:207–213
- . Clomiphene citrate with intrauterine insemination: is it effective therapy in women above the age of 35 years. Fertil Steril. 1996;65:759–763
- Park SJ, Alvarez JR, Weiss G, Von Hagen S, Smith D, McGovern PG. Ovulatory status and follicular response predict success of clomiphene citrate–intrauterine insemination. 2007;87:1102–7.
- . Factors affecting the pregnancy rate in clomiphene citrate induction of ovulation. Obstet Gynecol. 1983;62:196–202
- MacGregor AH, Johnson JE, Bunde CA. Induction of ovulation with clomiphene citrate. Presented at the 14th Annual Meeting of the Canadian Society for the Study of Fertility; Montreal; June 19–21, 1967.
- . Relationship of endometrial thickness and pattern to fecundity in ovulation induction cycles: effect of clomiphene citrate alone and with human menopausal gonadotropin. Fertil Steril. 1993;59:756–760
- . The effect of clomiphene on follicular phase increase in endometrial thickness and uterine volume. Fertil Steril. 1989;73:187–190
- . Treatment of infertile women with a deficient postcoital test with two antiestrogens: clomiphene and tamoxifen. Fertil Steril. 1989;41:237–243
- . The effect of three antioestrogen drugs on cervical mucus quality and in-vitro sperm–cervical mucus interaction in ovulatory women. Hum Reprod. 1993;8:437–441
- . The effect of ethinyl estradiol on endometrial thickness and uterine volume during ovulation induction by clomiphene citrate. Fertil Steril. 1992;57:33–36
- . Comparison of tamoxifen and clomiphene citrate for ovulation induction: a meta-analysis. Hum Reprod. 2005;20:1511–1515
- . A prospective randomized trial comparing clomiphene citrate for ovulation induction. Fertil Steril. 2001;75:1024–1026
- . Letrozole: ovulation or superovulation?. Fertil Steril. 2003;80:1335–1337
- . A randomized double-blind comparison of the effects of clomiphene citrate and the aromatase inhibitor letrozole on ovulatory function in normal. Fertil Steril. 2002;78:280–285
- . Aromatase inhibitors in ovulation induction. Semin Reprod Med. 2004;22:61–78
- . The outcome of 150 babies following the treatment with letrozole or letrozole and gonadotropins. Fertil Steril. 2005;(Suppl 1):84;O-231 (abstr. 1033)
- . High singleton live birth rate following classical ovulation induction in normogonadotrophic anovulatory infertility (WHO 2). Hum Reprod. 2003;18:2357–2362
- . Evaluation of the relative cost-effectiveness of treatments for infertility in the UK. Hum Reprod. 2000;15:95–106
- Prospective randomized trial comparing the outcome and cost of in vitro fertilization with that of a traditional treatment algorithm as first-line therapy for couples with infertility. Fertil Steril. 1999;71:468–475
- . Use of clomiphene citrate, human chorionic gonadotropins and human menopausal gonadotropins for induction of ovulation in the human female. Fertil Steril. 1966;17:569–583
- . Sequential clomiphene citrate and human menopausal gonadotropin with intrauterine insemination: the effect of patient age on clinical outcome. Hum Reprod. 1998;13:2110–2114
- . Intrauterine insemination treatment in subfertility: an analysis of factors affecting outcome. Hum Reprod. 1999;14:698–703
- . Controlled ovarian hyperinduction and intrauterine insemination should be limited to a maximum of three trials. Fertil Steril. 2001;75:88–91
- . Sequential clomiphene citrate and human menopausal gonadotropin for ovulation induction: comparison to clomiphene citrate alone and human menopausal gonadotropin alone. Hum Reprod. 1993;8:56–5
- . Cost-effectiveness of aromatase inhibitor co-treatment for controlled ovarian stimulation. Hum Reprod. 2006;21:2838–2844
- . Gonadotropins for induction of ovulation, immunological, pharmacological and clinical studies. [dissertation] Amsterdam: Free University; 1990;
- . Pharmacokinetics of follicle stimulating hormone: clinical significance. Fertil Steril. 1995;63:689–700
- . Low-dose FSH therapy for anovulatory infertility associated with polycystic ovary syndrome: rationale, results reflections and refinements. Hum Reprod Update. 1999;3:493–499
- Induction of ovulation with low-dose gonadotrophins in polycystic ovary syndrome: an analysis of 109 pregnancies in 225 women. J Clin Endocrinol Metab. 1996;81:3821–3824
- . The use of decremental dose regimen in patients treated with a chronic low-dose step-up protocol for WHO group I anovulation: a prospective randomized multicentre study. Hum Reprod. 2006;21:2817–2822
- . Low-dose exogenous FSH initiated during the early, mid, or late follicular phase can induce multiple dominant follicle development. Hum Reprod. 2001;16:846–854
- . Clinical review 15: management of ovulatory disorders with pulsatile gonadotropin-releasing hormone. J Clin Endocrinol Metab. 1990;71:1081A–G
- The use of LH activity to drive folliculogenesis: exploring uncharted territories in ovulation induction. Hum Reprod Update. 2002;8:543–547
- . Induction and growth of antral ovarian follicles by selective LH activity administration in women. Clin Endocrinol Metab. 2002;87:1156–1161
- . Pharmacokinetics and pharmacodynamics of exogenous gonadotropin administration. In Filicori M. Fourth World Congress on Ovulation Induction 2004: from anovulation to assisted reproduction. Rome: Aracne; 2004;123–58
- . Variation in the biological and biochemical characteristics of human menopausal gonadotropin. Fertil Steril. 1988;49:704–712
- Batch to batch consistency of human-derived gonadotrophin preparations compared to recombinant products. Reprod Biomed Online. 2005;10:442–454
- . Disappearance rates of endogenous luteinizing hormone and chorionic gonadotropin in man. J Clin Endocrinol. 1968;28:1763–1767
- . Clinical outcome following induction with highly purified hMG or recombinant FSH in patients undergoing IVF: a randomized assessor-blind controlled trial. Hum Reprod. 2006;21:3217–3227
- Comparison of controlled ovarian stimulation with human menopausal gonadotropin or recombinant follicle-stimulating hormone. Fertil Steril. 2003;80:390–397
- . Similar ovulation rates, but different follicular development with highly purified menotrophin compared with recombinant FSH in WHO group II anovulatory infertility: a randomized controlled study. Hum Reprod. 2006;21:1798–1804
- . Practice patterns among board-certified reproductive endocrinologists regarding high-order multiple gestations: a United States national survey. Obstet Gynecol. 2002;99:763–770
- . Homologous intrauterine insemination has no advantage over timed natural intercourse when used in combination with ovulation induction for the treatment of unexplained infertility. Hum Reprod. 1993;8:563–567
- . Success of intrauterine insemination using cryopreserved donor sperm is related to the age of the woman and the number of preovulatory follicles. J Assist Reprod Genet. 1996;13:310–314
- . ASRM educational bulletin: multiple pregnancy associated with infertility therapy, revised. Fertil Steril. 2006;86(Suppl 4):2106–2110
- . Efficacy of double intrauterine insemination in controlled ovarian hyperinduction cycles. Fertil Steril. 1999;72:619–622
- Efficacy of superovulation and insemination in the treatment of infertility. N Engl J Med. 1999;340:177–183
- . Use of a prediction model for high-order multiple implantations after ovarian induction with gonadotropins. Fertil Steril. 2005;83:116–121
- . Predictors of success during the coasting period in high-responder patients undergoing controlled ovarian induction for assisted conception. Fertil Steril. 2004;82:238–242
- . Management of overstimulated gonadotropin cycles with a controlled drift period. Hum Reprod. 1992;7:213–217
- . Une alternative à la superovul embryonnaire: la superovul folliculaire. Gynécologie. 1984;35:119–121
- . Selective follicular reduction following ovulation induction by exogenous gonadotropins in polycystic ovarian disease. A novel approach to treatment. Hum Reprod. 1991;6:682–684
- . Avoidance of multiple pregnancies after ovulation induction by supernumerary preovulatory follicle reduction. Fertil Steril. 2001;76:820–822
- . Experience with transvaginal ultrasound-guided aspiration of supernummary follicles for the prevention of multiple pregnancy agter ovulation induction and intrauterine insemination. Fertil Steril. 1996;65:1163–1168
- . Low multiple pregnancy rates and reduced frequency of cancellation after ovulation induction with gonadotropins, if eventual supernumerary follicles are aspirated to prevent polyovulation. J Assist Reprod Genet. 1998;15:111–118
- . Avoidance of cancellation of potential hyperinduction cycles by conversion to in vitro fertilization–embryo transfer. Fertil Steril. 1991;56:75–78
- . Conversion of cycles involving ovarian hyperinduction with intrauterine insemination to in-vitro induction. Hum Reprod. 1994;9:406–408
- Efficacy of transabdominal multifetal pregnancy reduction: collaborative experience among the world's largest centers. Obstet Gynecol. 1993;82:61–66
- Improvement in outcomes of multifetal pregnancy reduction with increased experience. Am J Obstet Gynecol. 2001;184:97–103
- . Pregnancy outcome after multifetal pregnancy reduction to twins compared with spontaneously conceived twins. Hum Reprod. 1996;11:1334–1336
- . Multifetal pregnancy reduction is not associated with an increased risk of intrauterine growth restriction, except for very-high-order multiples. Am J Obstet Gynecol. 1998;179:221–225
- . Triplets: outcomes of expectant management versus multifetal reduction for 127 pregnancies. Am J Obstet Gynecol. 2000;183:454–459
- . Fetal reduction from twins to a singleton: a reasonable consideration?. Obstet Gynecol. 2004;104:102–109
- CDC MMWR Weekly. Contribution of assisted reproductive technology and ovulation-inducing drugs to triplet and higher-order multiple births—United States, 1980–97. 2000:49(24):535–8
- . Trends in multiple births conceived using assisted reproductive technology, United States, 1997–2000. Pediatrics. 2003;111:1159–1162
- . The impact of ovulation induction and in vitro fertilization on incidence of multiple gestations. In: Blickstein I, Keith LG editor. Multiple pregnancy: epidemiology, gestation, and perinatal outcome. 2nd edition. London and NewYork: Taylor & Francis; 2005;p. 119–139
R.P.D. has nothing to disclose.
PII: S0015-0282(08)03305-0
doi: 10.1016/j.fertnstert.2008.08.008
© 2009 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
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Fertility and Sterility
Volume 91, Issue 1
, Pages 1-17
, January 2009

