Fertility and Sterility
Volume 92, Issue 4 , Pages 1290-1296 , October 2009

The p53 codon 72 single nucleotide polymorphism lacks a significant effect on implantation rate in fresh in vitro fertilization cycles: an analysis of 1,056 patients

  • George Patounakis, Ph.D.

      Affiliations

    • University of Medicine and Dentistry of New Jersey–Robert Wood Johnson Medical School, Piscataway, New Jersey
    • ,
  • Nathan Treff, Ph.D.

      Affiliations

    • University of Medicine and Dentistry of New Jersey–Robert Wood Johnson Medical School, Piscataway, New Jersey
    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • ,
  • Xin Tao, M.S.

      Affiliations

    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • ,
  • Agnieszka Lonczak, B.A.

      Affiliations

    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • ,
  • Richard T. Scott Jr., M.D., H.C.L.D.

      Affiliations

    • University of Medicine and Dentistry of New Jersey–Robert Wood Johnson Medical School, Piscataway, New Jersey
    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • ,
  • John L. Frattarelli, M.D.

      Affiliations

    • University of Medicine and Dentistry of New Jersey–Robert Wood Johnson Medical School, Piscataway, New Jersey
    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • Corresponding Author InformationReprint requests: John L. Frattarelli, M.D., Reproductive Medicine Associates of New Jersey, 100 Franklin Square Drive, Suite 200, Somerset, NJ 08873 (FAX: 732-537-0134).

Received 17 May 2008 ,Revised 29 July 2008 ,Accepted 31 July 2008.

References 

  1. Urman B. Recurrent implantation failure in assisted reproduction: how to counsel and manage. A. General considerations and treatment options that may benefit the couple. Reprod Biomed Online. 2005;11:371–381
  2. The International HapMap Consortium. A second generation human haplotype map of over 3.1 million SNPs. Nature. 2007;449:851–861
  3. Dobson AT, Davis RM, Rosen MP, Shen S, Rinaudo PF, Chan J, et al. Methylenetetrahydrofolate reductase C677T and A1298C variants do not affect ongoing pregnancy rates following IVF. Hum Reprod. 2007;22:450–456
  4. Haggarty P, McCallum H, McBain H, Andrews K, Duthie S, McNeill G, et al. Effects of B vitamins and genetics on success of in-vitro fertilisation: prospective cohort study. Lancet. 2006;367:1513–1519
  5. Coulam CB, Jeyendran RS, Fishel LA, Roussev R. Multiple thrombophilic gene mutations are risk factors for implantation failure. Reprod Biomed Online. 2006;12:322–327
  6. Cramer DW, Hornstein MD, McShane P, Powers RD, Lescault PJ, Vitonis AF, et al. Human progesterone receptor polymorphisms and implantation failure during in vitro fertilization. Am J Obstet Gynecol. 2003;189:1085–1092
  7. Wunsch A, Ahda Y, Banaz-Yasar F, Sonntag B, Nieschlag E, Simoni M, et al. Single-nucleotide polymorphisms in the promoter region influence the expression of the human follicle-stimulating hormone receptor. Fertil Steril. 2005;84:446–453
  8. Klinkert ER, te Velde ER, Weima S, van Zandvoort PM, Hanssen R, Nilsson PR, et al. FSH receptor genotype is associated with pregnancy but not with ovarian response in IVF. Reprod Biomed Online. 2006;13:687–695
  9. Georgiou I, Konstantelli M, Syrrour M, Messinis IE, Lolis DE. Oestrogen receptor gene polymorphisms and ovarian stimulation for in-vitro fertilization. Hum Reprod. 1997;12:1430–1433
  10. Hu W, Feng Z, Teresky AK, Levine AJ. p53 regulates maternal reproduction through LIF. Nature. 2007;450:721–724
  11. Vousden KH, Lane DP. p53 in health and disease. Nat Rev Mol Cell Biol. 2007;8:275–283
  12. Thomas M, Kalita A, Labrecque S, Pim D, Banks L, Matlashewski G. Two polymorphic variants of wild-type p53 differ biochemically and biologically. Mol Cell Biol. 1999;19:1092–1100
  13. Olschwang S, Laurent-Puig P, Vassal A, Salmon RJ, Thomas G. Characterization of a frequent polymorphism in the coding sequence of the Tp53 gene in colonic cancer patients and a control population. Hum Genet. 1991;86:369–370
  14. Zehbe I, Voglino G, Wilander E, Delius H, Marongiu A, Edler L, et al. p53 Codon 72 polymorphism and various human papillomavirus 16 E6 genotypes are risk factors for cervical cancer development. Cancer Res. 2001;61:608–611
  15. Chang CC, Hsieh YY, Tsai FJ, Tsai CH, Tsai HD, Lin CC. The proline form of p53 codon 72 polymorphism is associated with endometriosis. Fertil Steril. 2002;77:43–45
  16. Vietri MT, Molinari AM, Iannella I, Cioffi M, Bontempo P, Ardovino M, et al. Arg72Pro p53 polymorphism in Italian women: no association with endometriosis. Fertil Steril. 2007;88:1468–1469
  17. Lattuada D, Vigano P, Somigliana E, Abbiati A, Candiani M, Di Blasio AM. Analysis of the codon 72 polymorphism of the TP53 gene in patients with endometriosis. Mol Hum Reprod. 2004;10:651–654
  18. Kay C, Jeyendran RS, Coulam CB. p53 tumor suppressor gene polymorphism is associated with recurrent implantation failure. Reprod Biomed Online. 2006;13:492–496
  19. Coulam CB, Kay C, Jeyendran RS. Role of p53 codon 72 polymorphism in recurrent pregnancy loss. Reprod Biomed Online. 2006;12:378–382
  20. Pietrowski D, Bettendorf H, Riener E-K, Keck C, Hefler LA, Huber JC, et al. Recurrent pregnancy failure is associated with a polymorphism in the p53 tumour suppressor gene. Hum Reprod. 2005;20:848–851
  21. Gleicher N, Barad D. Unexplained infertility: does it really exist?. Hum Reprod. 2006;21:1951–1955

 G.P. has nothing to disclose. N.T. has nothing to disclose. X.T. has nothing to disclose. A.L. has nothing to disclose. R.T.S. has nothing to disclose. J.L.F. has nothing to disclose.

 Supported by Ferring Pharmaceuticals, Saint-Prex, Switzerland, with an unrestricted research grant.

PII: S0015-0282(08)03566-8

doi: 10.1016/j.fertnstert.2008.07.1783

Fertility and Sterility
Volume 92, Issue 4 , Pages 1290-1296 , October 2009

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