Fertility and Sterility
Volume 92, Issue 5 , Pages 1557-1561 , November 2009

Risk of birth defects increased in pregnancies conceived by assisted human reproduction

  • Darine El-Chaar, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology and Neonatal Care, Ottawa Health Research Institute, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Qiuying Yang, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology and Neonatal Care, Ottawa Health Research Institute, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
    • OMNI Research Group, Ottawa Health Research Institute, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Jun Gao, M.D.

      Affiliations

    • OMNI Research Group, Ottawa Health Research Institute, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Jim Bottomley, M.H.A.

      Affiliations

    • Ontario Perinatal Surveillance System, Ottawa Health Research Institute, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Arthur Leader, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology and Neonatal Care, Ottawa Health Research Institute, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
    • The Ottawa Fertility Centre, Ottawa Health Research Institute, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Shi Wu Wen, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology and Neonatal Care, Ottawa Health Research Institute, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
    • OMNI Research Group, Ottawa Health Research Institute, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Mark Walker, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology and Neonatal Care, Ottawa Health Research Institute, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
    • OMNI Research Group, Ottawa Health Research Institute, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
    • Ontario Perinatal Surveillance System, Ottawa Health Research Institute, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
    • Corresponding Author InformationReprints requests: Dr. Mark Walker, The Ottawa Hospital, General Campus, 501 Smyth Road, Box 241, Room 1818, Ottawa, ON K1H 8L6 (FAX: 613-739-6266).

Received 28 February 2008 ,Revised 23 July 2008 ,Accepted 7 August 2008.

References 

  1. Nyboe Andersen A, Goossens V, Gianaroli L, Felberbaum R, de Mouzon J, Nygren KG. Assisted reproductive technology in Europe, 2003. Results generated from European registers by ESHRE. Hum Reprod. 2007;22:1513–1525
  2. Assisted reproductive technology in the United States: 2001 results generated from the American Society for Reproductive Medicine/Society for Assisted Reproductive Technology registry. Fertil Steril. 2007;87:1253–1266
  3. Dhont M, De Neubourg F, Van der Elst J, De Sutter P. Perinatal outcome of pregnancies after assisted reproduction: a case-control study. J Assist Reprod Genet. 1997;14:575–580
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 D.E.-C. has nothing to disclose. Q.Y. has nothing to disclose. J.G. has nothing to disclose. J.B. has nothing to disclose. A.L. has nothing to disclose. S.W.W. has nothing to disclose. M.W. has nothing to disclose.

 This project was presented at the Society of Maternal Fetal Medicine's 27th Annual Scientific Meeting, which was held in San Francisco on February 9, 2007.

 This study was done in partnership with the Ontario Perinatal Surveillance System. Drs. Wen and Walker are recipients of a New Investigator's Award from CIHR.

 This study was part of the Program on Oocyte Health, funded under the Healthy Gametes and Great Embryos Strategic Initiative of the Canadian Institutes of Health Research (CIHR) Institute of Human Development, Child and Youth Health (IHDCYH) (grant no: HGG62293).

PII: S0015-0282(08)03574-7

doi: 10.1016/j.fertnstert.2008.08.080

Fertility and Sterility
Volume 92, Issue 5 , Pages 1557-1561 , November 2009

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