Fertility and Sterility
Volume 92, Issue 5 , Pages 1532-1535 , November 2009

CYP17 and CYP19 gene polymorphisms in women affected with endometriosis

  • Maria Teresa Vietri, M.D.

      Affiliations

    • Department of General Pathology, Second Medical School of Naples, Naples, Italy
    • ,
  • Michele Cioffi, M.D.

      Affiliations

    • Department of General Pathology, Second Medical School of Naples, Naples, Italy
    • Corresponding Author InformationReprint requests: Michele Cioffi, M.D., General Pathology, Second Medical School Naples, Via Luigi de Crecchio, 7, 80138 Naples, Italy (FAX: +39081450169).
    • ,
  • Marcella Sessa, Ph.D.

      Affiliations

    • Department of General Pathology, Second Medical School of Naples, Naples, Italy
    • ,
  • Serena Simeone, M.D.

      Affiliations

    • Department of General Pathology, Second Medical School of Naples, Naples, Italy
    • ,
  • Paola Bontempo, M.D.

      Affiliations

    • Department of General Pathology, Second Medical School of Naples, Naples, Italy
    • ,
  • Elisabetta Trabucco, M.D.

      Affiliations

    • Department of Gynaecology, Obstetrics and Reproductive Medicine, Second Medical School of Naples, Naples, Italy
    • ,
  • Mario Ardovino, M.D.

      Affiliations

    • Department of Gynaecology, Obstetrics and Reproductive Medicine, Second Medical School of Naples, Naples, Italy
    • ,
  • Nicola Colacurci, M.D.

      Affiliations

    • Department of Gynaecology, Obstetrics and Reproductive Medicine, Second Medical School of Naples, Naples, Italy
    • ,
  • Anna Maria Molinari, M.D.

      Affiliations

    • Department of General Pathology, Second Medical School of Naples, Naples, Italy
    • ,
  • Luigi Cobellis, M.D.

      Affiliations

    • Department of Gynaecology, Obstetrics and Reproductive Medicine, Second Medical School of Naples, Naples, Italy

Received 30 January 2008 ,Revised 8 July 2008 ,Accepted 30 July 2008.

References 

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  2. Kennedy S. Genetics of endometriosis: a review of the positional cloning approaches. Semin Reprod Med. 2003;21:111–118
  3. Vietri MT, Molinari AM, Iannella I, Cioffi M, Bontempo P, Ardovino M, et al. Arg72Pro p53 polymorphism in Italian women: no association with endometriosis. Fert Steril. 2007;88:1468–1469
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  5. Kado N, Kitawaki J, Obayashi H, Ishihara H, Koshiba I, Kusuki K, et al. Association of the CYP17 gene and CYP19 gene polymorphisms with risk of endometriosis in Japonese woman. Hum Reprod. 2002;17:897–902
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  11. Feigelson HS, Shames LS, Pike MC, Coetzee GA, Stanczyk FZ, Henderson BE. Cytochrome P450c17alpha gene (CYP17) polymorphism is associated with serum estrogen and progesterone concentrations. Cancer Res. 1998;58:585
  12. Gennari L, Nuti R, Bilezikian JP. Aromatase activity and bone homeostasis in men. J Clin Endocrinol Metab. 2004;89:5898–5907
  13. Kristensen VN, Harada N, Yoshimura N, Haraldsen E, Lonning PE, Erikstein B, et al. Genetic variant of CYP19 (aromatase) and brest cancer risk. Oncogene. 2000;19:1329–1333
  14. Siegelmann-Danieli N, Buetow KH. Costitutional genetic variant at the human aromatase gene (CYP19) and breast cancer risk. Br J Cancer. 1999;79:456–463
  15. Hsieh YY, Chang CC, Tsai FJ, Lin CC, Tsai CH. Cytochrome P450c17alpha 5′-untranslated region ∗T/C polymorphism in endometriosis. J Genet. 2004;83:189–192
  16. Juo SH, Wang TN, Lee JN, Wu MT, Long CY, CYP17 Tsai EM. CYP1A1 and COMT polymorphisms and the risk of adenomyosis and endometriosis in Taiwanese women. Hum Reprod. 2006;21:1498–1502
  17. Huber A, Keck CC, Hefler LA, Schneeberger C, Huber JC, Bentz EK, et al. Ten estrogen-related polymorphisms and endometriosis: a study of multiple gene-gene interactions. Obstet Gynecol. 2005;106:1025–1031
  18. The World Medical Association (WMA). The WMA declaration of Helsinki 1960 with recommendations on biomedical research on human subjects (modified in 1975, 1980 and 1989). Chirurgia (Bucur). 1998;93:138–140
  19. American Fertility Society—Revised American Fertility Society. Classification of endometriosis. Fertil Steril. 1985;43:351–352
  20. Redwine DB. "Invisible" microscopic endometriosis: a review. Gynecol Obstet Invest. 2003;55:63
  21. Tofteng CL, Kindmark A, Brandstrom H, Abrahamsen B, Petersen S, Stiger F, et al. Polymorphisms in the CYP19 and AR genes-relation to bone mass and longitudinal bone changes in postmenopausal women with or without hormone replacement therapy: the Danish Osteoporosis Prevention Study. Calcif Tissue Int. 2004;74:25–34
  22. Somner J, McLellan S, Cheung J, Mak YT, Frost ML, Knapp KM, et al. Polymorphisms in the P450 c17 (17-hydroxylase/17,20-Lyase) and P450 c19 (aromatase) genes: association with serum sex steroid concentrations and bone mineral density in postmenopausal women. J Clin Endocrinol Metab. 2004;89:344–351

 M.T.V. has nothing to declare. M.C. has nothing to declare. M.S. has nothing to declare. S.S. has nothing to declare. P.B. has nothing to declare. E.T. has nothing to declare. M.A. has nothing to declare. N.C. has nothing to declare. A.M.N. has nothing to declare. L.C. has nothing to declare.

 Teresa Vietri and Michele Cioffi contributed equally to this article.

PII: S0015-0282(08)03577-2

doi: 10.1016/j.fertnstert.2008.07.1786

Fertility and Sterility
Volume 92, Issue 5 , Pages 1532-1535 , November 2009

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