Fertility and Sterility
Volume 92, Issue 5 , Pages 1579-1585 , November 2009

The sex ratio of singleton offspring in assisted-conception pregnancies

  • Barbara Luke, Sc.D., M.P.H.

      Affiliations

    • Department of Obstetrics, Gynecology, and Reproductive Biology and Department of Epidemiology, Michigan State University, East Lansing, Michigan
    • Corresponding Author InformationReprint requests: Barbara Luke, Sc.D., M.P.H., Department of Obstetrics, Gynecology, and Reproductive Biology and Department of Epidemiology, B227 West Fee Hall, Michigan State University, East Lansing, Michigan 48824 (FAX: 517-353-1663).
  • ,
  • Morton B. Brown, Ph.D.

      Affiliations

    • Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan
  • ,
  • David A. Grainger, M.D., M.P.H.

      Affiliations

    • Center for Reproductive Medicine, University of Kansas, Wichita, Kansas
  • ,
  • Valerie L. Baker, M.D.

      Affiliations

    • Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University Medical Center, Stanford, California
  • ,
  • Elizabeth Ginsburg, M.D.

      Affiliations

    • Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts
  • ,
  • Judy E. Stern, Ph.D.

      Affiliations

    • Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
  • ,
  • Society for Assisted Reproductive Technology Writing Group

Received 21 July 2008 ,Revised 20 August 2008 ,Accepted 20 August 2008.

References 

  1. Jongbloet PH. Fetal sex and very preterm birth. Am J Obstet Gynecol. 2005;193:302
  2. Kukharenko VI. The primary sex ratio in man (analysis of 1,014 embryos). Genetika. 1970;6:142–149
  3. Smith GG. Sex, birth weight, and the risk of stillbirth in Scotland, 1980–1996. Am J Epidemiol. 2000;151:614–619
  4. Vatten LJ, Skjærven R. Offspring and pregnancy outcome by length of gestation. Early Hum Devel. 2004;76:47–54
  5. Mathews TJ, Hamilton BE. Trend analysis of the sex ratio at birth in the United States. Nat Vital Stat Rep. 2005;53:1–18
  6. Marcus M, Kiely J, Xu F, McGeehin M, Jackson R, Sinks T. Changing sex ratio in the United States, 1969–1995. Fertil Steril. 1998;70:270–273
  7. Nicolich MJ, Huebner WW, Schnatter AR. Influence of parental and biological factors on the male birth fraction in the United States: an analysis of birth certificate data from 1964 through 1988. Fertil Steril. 2000;73:487–492
  8. Martin JA, Hamilton BE, Sutton PD, Ventura SJ, Menacker F, Kirmeyer S, et al. Births: final data for 2005. Nat Vital Stat Rep. 2007;56:1–104
  9. Jacobsen R. Parental ages and secondary sex ratio. Hum Reprod. 2001;16:2244
  10. Fukuda M, Fukuda K, Shimizu T, Moller H. Decline in sex ratio at birth after Kobe earthquake. Hum Reprod. 1998;13:2321–2322
  11. Fukuda M, Fukuda K, Shimizu T, Anderson CY, Byskov AG. Parental periconceptional smoking and male:female ratio of newborn infants. Lancet. 2002;359:1407–1408
  12. Cagnacci A, Renzi A, Arangino S, Alessandrini C, Volpe A. Influences of maternal weight on the secondary sex ratio of human offspring. Hum Reprod. 2004;19:442–444
  13. Catalano RA. Sex ratios in the two Germanies: a test of the economic stress hypothesis. Hum Reprod. 2003;18:1972–1975
  14. Ryan JJ, Amirova Z, Carrier G. Sex ratios of children of Russian pesticide producers exposed to dioxin. Environ Health Perspect. 2002;110:A699–A701
  15. Ding QJ, Hesketh T. Family size, fertility preferences, and sex ratio in China in the era of the one child family policy: results from national family planning and reproductive health survey. Br Med J. 2006;333:371–373
  16. Gu B, Roy K. Sex ratio at birth in China, with reference to other areas in East Asia: what we know. Asia-Pacific Pop J. 1995;10:17–42
  17. Jacobsen R, Bostofte E, Engholm G, Hansen J, Skakkabæk NE, Møller H. Fertility and offspring sex ratio of men who develop testicular cancer: a record linkage study. Hum Reprod. 2000;15:1958–1961
  18. Jacobsen R, Bostofte E, Skakkabæk NE, Hansen J, Møller H. Offspring sex ratio of subfertile men and men with abnormal sperm characteristics. Hum Reprod. 2000;15:2369–2370
  19. Jakobovits A, Jakobovits AA, Viski A. Sex ratio of the stillborn fetuses and neonates dying in the first week. Early Hum Devel. 1987;15:131–135
  20. Zeitlin J, Ancel P-Y, Larroque B, Kaminski M EPIPAGE group. Fetal sex and indicated very preterm birth: results of the EPIPAGE study. Am J Obstet Gynecol. 2004;190:1322–1325
  21. Di Renzo GC, Rosati A, Sarti RD, Cruciani L, Cutuli AM. Does fetal sex affect pregnancy outcome?. Gender Med. 2007;4:19–30
  22. Graffelman J, Fugger EF, Keyvanfar K, Schulman JD. Human live birth and sperm—sex ratios compared. Hum Reprod. 1999;14:2917–2919
  23. Bahadur G, Ling KLE, Priya S, Davis CJ, Wafa R, Ashraf A. Sex ratio and maternal age effect in nulliparous women receiving donor insemination. Fertil Steril. 2001;75:219–220
  24. Fedder J, Gabrielsen A, Humaidan P, Erb K, Ernst E, Loft A. Malformation rate and sex ratio in 412 children conceived with epididymal or testicular sperm. Hum Reprod. 2007;22:1080–1085
  25. Luna M, Duke M, Copperman A, Grunfeld L, Sandler B, Barritt J. Blastocyst embryo transfer is associated with a sex-ratio imbalance in favor of male offspring. Fertil Steril. 2007;87:519–523
  26. Silverman AY, Stephens SR, Drouin MT, Zack RG, Osborne J, Ericsson SA. Female sex selection using chlomiphene citrate and albumin separation of human sperm. Hum Reprod. 2002;17:1254–1256
  27. Barczyk A. Sperm capacitation and primary sex ratio. Med Hypoth. 2001;56:737–738
  28. Yan J, Feng HL, Chen Z, Hu J, Gao X, Qin Y. Influence of swim-up on the ratio of X- and Y-bearing spermatozoa. Eur J Obstet Gynecol Reprod Biol. 2006;129:150–154
  29. Macas E, Imthurn B, Keller PJ. Increased incidence of numerical chromosome abnormalities in spermatozoa injected into human oocytes by ICSI. Hum Reprod. 2001;16:115–120
  30. Allen C, Reardon W. Assisted reproduction technology and defects of genomic imprinting. Br J Obstet Gynecol. 2005;112:1589–1594
  31. Menezo Y. Paternal and maternal factors in preimplantation embryogeneisis: interaction with the biochemical environment. Reprod Biomed Online. 2006;12:616–621
  32. Emery BR, Carrell DT. The effect of epigenetic sperm abnormalities on early embryogenesis. Asian J Androl. 2006;8:131–142
  33. Jain T, Gupta RS. Trends in the use of intracytoplasmic sperm injection in the United States. New Engl J Med. 2007;357:251–257

 B.L. has nothing to disclose. M.B.B. has nothing to disclose. D.A.G. has nothing to disclose. V.L.B. has nothing to disclose. E.G. has nothing to disclose. J.E.S. has nothing to disclose.

 This study was supported by the Society for Assisted Reproductive Technology. V.L.B. received research support from Institut Biochimique SA (IBSA).

 Presented at the 63rd annual meeting of the American Society for Reproductive Medicine, which was held in Washington, D.C., on October 13–17, 2007.

PII: S0015-0282(08)03726-6

doi: 10.1016/j.fertnstert.2008.08.107

Fertility and Sterility
Volume 92, Issue 5 , Pages 1579-1585 , November 2009