Fertility and Sterility
Volume 92, Issue 5 , Pages 1569-1578 , November 2009

A proteomic analysis of IVF follicular fluid in women ≤32 years old

  • Stephanie J. Estes, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
    • ,
  • Bin Ye, Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
    • ,
  • Weiliang Qiu, Ph.D.

      Affiliations

    • Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
    • ,
  • Daniel Cramer, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
    • Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
    • ,
  • Mark D. Hornstein, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
    • ,
  • Stacey A. Missmer, Sc.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
    • Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
    • Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
    • Corresponding Author InformationReprint requests: Stacey A. Missmer, Sc.D., OB/GYN Epidemiology Center, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115–5804 (FAX: 617-732-4899).

Received 2 February 2008 ,Revised 16 August 2008 ,Accepted 24 August 2008.

References 

  1. Petricoin EF, Ardekani AM, Hitt BA, Levine PJ, Fusaro VA, Steinberg SM, et al. Use of proteomic patterns in serum to identify ovarian cancer. Lancet. 2002;359:572–577
  2. Ye B, Cramer DW, Skates SJ, Gygi SP, Pratomo V, Fu L, et al. Haptoglobin-alpha subunit as potential serum biomarker in ovarian cancer: identification and characterization using proteomic profiling and mass spectrometry. Clin Cancer Res. 2003;9:2904–2911
  3. Wright GL, Cazares LH, Leung SM, Nasim S, Adam BL, Yip TT, et al. Proteinchip surface enhanced laser desorption/ionization (SELDI) mass spectrometry: a novel protein biochip technology for detection of prostate cancer biomarkers in complex protein mixtures. Prostate Cancer Prostatic Dis. 1999;2:264–276
  4. Wong YF, Cheung TH, Lo KW, Wang VW, Chan CS, Ng TB, et al. Protein profiling of cervical cancer by protein-biochips: proteomic scoring to discriminate cervical cancer from normal cervix. Cancer Lett. 2004;211:227–234
  5. Gravett MG, Novy MJ, Rosenfeld RG, Reddy AP, Jacob T, Turner M, et al. Diagnosis of intra-amniotic infection by proteomic profiling and identification of novel biomarkers. JAMA. 2004;292:462–469
  6. Park SJ, Yoon WG, Song JS, Jung HS, Kim CJ, Oh SY, et al. Proteome analysis of human amnion and amniotic fluid by two-dimensional electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Proteomics. 2006;6:349–363
  7. Gerton GL, Fan XJ, Chittams J, Sammel M, Hummel A, Strauss JF, et al. A serum proteomics approach to the diagnosis of ectopic pregnancy. Ann N Y Acad Sci. 2004;1022:306–316
  8. Kim YS, Kim MS, Lee SH, Choi BC, Lim JM, Cha KY, et al. Proteomic analysis of recurrent spontaneous abortion: identification of an inadequately expressed set of proteins in human follicular fluid. Proteomics. 2006;6:3445–3454
  9. Katz-Jaffe MG, Gardner DK, Schoolcraft WB. Proteomic analysis of individual human embryos to identify novel biomarkers of development and viability. Fertil Steril. 2006;85:101–107
  10. Shankar R, Gude N, Cullinane F, Brennecke S, Purcell AW, Moses EK. An emerging role for comprehensive proteome analysis in human pregnancy research. Reproduction. 2005;129:685–696
  11. Block E. Quantitative morphological investigations of the follicular system in women: variation at different ages. Acta Anat. 1952;14:108–123
  12. Faddy MJ, Gosden RG, Gougeon A, Richardson SJ, Nelson JF. Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause. Hum Reprod. 1992;7:1342–1346
  13. Thomford PJ, Jelovsek FR, Mattison DR. Effect of oocyte number and rate of atresia on the age of menopause. Reprod Toxicol. 1987;1:41–51
  14. Toner JP, Philput CB, Jones GS, Muasher SJ. Basal follicle-stimulating hormone level is a better predictor of in vitro fertilization performance than age. Fertil Steril. 1991;55:784–791
  15. van Rooij IA, Broekmans FJ, Scheffer GJ, Looman CW, Habbema JD, de Jong FH, et al. Serum antimullerian hormone levels best reflect the reproductive decline with age in normal women with proven fertility: a longitudinal study. Fertil Steril. 2005;83:979–987
  16. Yanushpolsky EH, Hurwitz S, Tikh E, Racowsky C. Predictive usefulness of cycle day 10 follicle-stimulating hormone level in a clomiphene citrate challenge test for in vitro fertilization outcome in women younger than 40 years of age. Fertil Steril. 2003;80:111–115
  17. Jain T, Soules MR, Collins JA. Comparison of basal follicle-stimulating hormone versus the clomiphene citrate challenge test for ovarian reserve screening. Fertil Steril. 2004;82:180–185
  18. Cramer DW, Liberman RF, Powers D, Hornstein MD, McShane P, Barbieri RL. Recent trends in assisted reproductive techniques and associated outcomes. Obstet Gynecol. 2000;95:61–66
  19. Terry DE, Desiderio DM. Between-gel reproducibility of the human cerebrospinal fluid proteome. Proteomics. 2003;3:1962–1979
  20. Ye B, Skates S, Mok SC, Horick NK, Rosenberg HF, Vitonis A, et al. Proteomic-based discovery and characterization of glycosylated eosinophil-derived neurotoxin and COOH-terminal osteopontin fragments for ovarian cancer in urine. Clin Cancer Res. 2006;12:432–441
  21. Greenland S. Modeling and variable selection in epidemiologic analysis. Am J Public Health. 1989;79:340–349
  22. Quenouille M. Notes on bias in estimation. Biometrika. 1956;43:353–360
  23. Kutteh WH, Triplett DA. Thrombophilias and recurrent pregnancy loss. Semin Reprod Med. 2006;24:54–66
  24. Qublan HS, Eid SS, Ababneh HA, Amarin ZO, Smadi AZ, Al-Khafaji FF, et al. Acquired and inherited thrombophilia: implication in recurrent IVF and embryo transfer failure. Hum Reprod. 2006;21:2694–2698
  25. Azem F, Many A, Ben Ami I, Yovel I, Amit A, Lessing JB, et al. Increased rates of thrombophilia in women with repeated IVF failures. Hum Reprod. 2004;19:368–370
  26. Martinelli I, Taioli E, Ragni G, Levi-Setti P, Passamonti SM, Battaglioli T, et al. Embryo implantation after assisted reproductive procedures and maternal thrombophilia. Haematologica. 2003;88:789–793
  27. Aune B, Hoie KE, Oian P, Holst N, Osterud B. Does ovarian stimulation for in-vitro fertilization induce a hypercoagulable state?. Hum Reprod. 1991;6:925–927
  28. Angelucci S, Ciavardelli D, Di Giuseppe F, Eleuterio E, Sulpizio M, Tiboni GM, et al. Proteome analysis of human follicular fluid. Biochim Biophys Acta. 2006;1764:1775–1785
  29. Chen XJ, Clark-Walker GD. Specific mutations in alpha- and gamma-subunits of F1-ATPase affect mitochondrial genome integrity in the petite-negative yeast Kluyveromyces lactis. EMBO J. 1995;14:3277–3286
  30. Chen XJ, Clark-Walker GD. The mitochondrial genome integrity gene, MGI1, of Kluyveromyces lactis encodes the beta-subunit of F1-ATPase. Genetics. 1996;144:1445–1454
  31. Park DW, Cho T, Kim MR, Kim YA, Min CK, Hwang KJ. ATP-induced apoptosis of human granulosa luteal cells cultured in vitro. Fertil Steril. 2003;80:993–1002
  32. Tai CJ, Kang SK, Choi KC, Tzeng CR, Leung PC. Antigonadotropic action of adenosine triphosphate in human granulosa-luteal cells: involvement of protein kinase C alpha. J Clin Endocrinol Metab. 2001;86:3237–3242
  33. Shimada H, Kasakura S, Shiotani M, Nakamura K, Ikeuchi M, Hoshino T, et al. Hypocoagulable state of human preovulatory ovarian follicular fluid: role of sulfated proteoglycan and tissue factor pathway inhibitor in the fluid. Biol Reprod. 2001;64:1739–1745
  34. Ridgway HJ, Brennan SO, Faed JM, George PM. Fibrinogen Otago: a major alpha chain truncation associated with severe hypofibrinogenaemia and recurrent miscarriage. Br J Haematol. 1997;98:632–639
  35. Haverkate F, Samama M. Familial dysfibrinogenemia and thrombophilia. Report on a study of the SSC Subcommittee on Fibrinogen. Thromb Haemost. 1995;73:151–161
  36. Schweigert FJ, Gericke B, Wolfram W, Kaisers U, Dudenhausen JW. Peptide and protein profiles in serum and follicular fluid of women undergoing IVF. Hum Reprod. 2006;21:2960–2968
  37. Nagy B, Pulay T, Szarka G, Csomor S. The serum protein content of human follicular fluid and its correlation with the maturity of oocytes. Acta Physiol Hung. 1989;73:71–75
  38. Spitzer D, Murach KF, Lottspeich F, Staudach A, Illmensee K. Different protein patterns derived from follicular fluid of mature and immature human follicles. Hum Reprod. 1996;11:798–807
  39. Aleporou-Marinou V, Pappa H, Yalouris P, Patargias T. Purification of apolipoprotein H (beta 2-glycoprotein I)–like protein from human follicular fluid. Comp Biochem Physiol B Biochem Mol Biol. 2001;128:537–542
  40. Stepanovic S, Djukic S, Veljkovic M, Arsic B, Garalejic E, Ranin L. Antimicrobial activity of human follicular fluids. Gynecol Obstet Invest. 2003;56:173–178
  41. Clarke GN, Hsieh C, Koh SH, Cauchi MN. Sperm antibodies, immunoglobulins, and complement in human follicular fluid. Am J Reprod Immunol. 1984;5:179–181
  42. el-Roeiy A, Gleicher N, Friberg J, Confino E, Dudkiewicz A. Correlation between peripheral blood and follicular fluid autoantibodies and impact on in vitro fertilization. Obstet Gynecol. 1987;70:163–170
  43. Mantzavinos T, Dalamanga N, Hassiakos D, Dimitriadou F, Gregoriou O, Zourlas PA. Immunoglobulins IgG, IgA, IgM, complement C3, C4 and ferritin and transferrin levels in serum and follicular fluid in IVF patients. Clin Exp Obstet Gynecol. 1993;20:32–36
  44. Anahory T, Dechaud H, Bennes R, Marin P, Lamb NJ, Laoudj D. Identification of new proteins in follicular fluid of mature human follicles. Electrophoresis. 2002;23:1197–1202
  45. Lee HC, Lee SW, Lee KW, Lee SW, Cha KY, Kim KH, et al. Identification of new proteins in follicular fluid from mature human follicles by direct sample rehydration method of two-dimensional polyacrylamide gel electrophoresis. J Korean Med Sci. 2005;20:456–460
  46. Combelles CM, Racowsky C. Protein expression profiles of early embryos—an important step in the right direction: just not quite ready for prime time. Fertil Steril. 2006;86:493;;author reply 493
  47. Andersen MM, Kroll J, Byskov AG, Faber M. Protein composition in the fluid of individual bovine follicles. J Reprod Fertil. 1976;48:109–118

 S.E. has nothing to disclose. B.Y. has nothing to disclose. W.Q. has nothing to disclose. D.C. has nothing to disclose. M.H. has nothing to disclose. S.M. has nothing to disclose.

 Supported by National Institutes of Health grant no. HD32153 and the research fund of the Department of Obstetrics and Gynecology, Brigham and Women's Hospital.

PII: S0015-0282(08)03830-2

doi: 10.1016/j.fertnstert.2008.08.120

Fertility and Sterility
Volume 92, Issue 5 , Pages 1569-1578 , November 2009

Article Tools

* Image Usage & Resolution