Fertility and Sterility
Volume 92, Issue 6 , Pages 1960-1965 , December 2009

Clinical and biochemical presentations of polycystic ovary syndrome among obese and nonobese women

  • Tsan-Hon Liou, M.D., Ph.D.

      Affiliations

    • Obesity Research Center, Taipei Medical University-Wan Fang Medical Center, Taipei, Taiwan
    • Graduate Institute of Injury Prevention and Control, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan
    • ,
  • Jen-Hung Yang, M.D., Ph.D.

      Affiliations

    • Department of Dermatology, Chung Shan Medical University Hospital, Taichung, Taiwan
    • ,
  • Ching-Hung Hsieh, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Taipei Medical University-Wan Fang Medical Center, Taipei, Taiwan
    • ,
  • Ching-Yin Lee, M.S.

      Affiliations

    • Department of Obstetrics and Gynecology, Taipei Medical University-Wan Fang Medical Center, Taipei, Taiwan
    • ,
  • Chun-Sen Hsu, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Taipei Medical University-Wan Fang Medical Center, Taipei, Taiwan
    • ,
  • Ming-I. Hsu, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Taipei Medical University-Wan Fang Medical Center, Taipei, Taiwan
    • Corresponding Author InformationReprint requests: Ming-I Hsu, M.D., Department of Obstetrics and Gynecology, Taipei Medical University-Wan Fang Medical Center, 111 Hsing-Lung Road, Section 3, Taipei 116 Taiwan (FAX: 886-2-29300036).

Received 12 June 2008 ,Revised 28 August 2008 ,Accepted 2 September 2008.

References 

  1. Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yildiz BO. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab. 2004;89:2745–2749
  2. Abbott DH, Dumesic DA, Franks S. Developmental origin of polycystic ovary syndrome—a hypothesis. J Endocrinol. 2002;174:1–5
  3. Dunaif A, Segal KR, Futterweit W, Dobrjansky A. Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes. 1989;38:1165–1174
  4. Hoeger K. Obesity and weight loss in polycystic ovary syndrome. Obstet Gynecol Clin North Am. 2001;28:85–97
  5. Barber TM, McCarthy MI, Wass JA, Franks S. Obesity and polycystic ovary syndrome. Clin Endocrinol. 2006;65:137–145
  6. Gambineri A, Pelusi C, Vicennati V, Pagotto U, Pasquali R. Obesity and the polycystic ovary syndrome. Int J Obes. 2002;26:883–896
  7. Hsu MI, Liou TH, Liang SJ, Su HW, Wu CH, Hsu CS. Inappropriate gonadotropin secretion in polycystic ovary syndrome. Fertil Steril. 2008;in press
  8. Moran C, Garcia-Hernandez E, Barahona E, Gonzalez S, Bermudez JA. Relationship between insulin resistance and gonadotropin dissociation in obese and nonobese women with polycystic ovary syndrome. Fertil Steril. 2003;80:1466–1472
  9. The Asia-Pacific Perspective: Redefining Obesity and Its Treatment. Melbourne: International Diabetes Institute; 2000;
  10. The Rotterdam ESHRE/ASRM-sponsored PCOS workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81:19–25
  11. Hsu MI, Liou TH, Chou SY, Chang CY, Hsu CS. Diagnostic criteria for polycystic ovary syndrome in Taiwanese Chinese women: comparison between Rotterdam 2003 and NIH 1990. Fertil Steril. 2007;88:727–729
  12. Bloom MS, Schisterman EF, Hediger ML. Selecting controls is not selecting “normals”: design and analysis issues for studying the etiology of polycystic ovary syndrome. Fertil Steril. 2006;86:1–12
  13. Jonard S, Robert Y, Dewailly D. Revisiting the ovarian volume as a diagnostic criterion for polycystic ovaries. Hum Reprod. 2005;20:2893–2898
  14. Hart R, Hickey M, Franks S. Definitions, prevalence and symptoms of polycystic ovaries and polycystic ovary syndrome. Best Pract Res Clin Obstet Gynaecol. 2004;18:671–683
  15. Chan CC, Ng EH, Tang OS, Lee CP, Ho PC. The prevalence of polycystic ovaries in Chinese women with a history of gestational diabetes mellitus. Gynecol Endocrinol. 2006;22:516–520
  16. Kiddy DS, Sharp PS, White DM, Scanlon MF, Mason HD, Bray CS, et al. Differences in clinical and endocrine features between obese and non-obese subjects with polycystic ovary syndrome: an analysis of 263 consecutive cases. Clin Endocrinol. 1990;32:213–220
  17. Singh KB, Mahajan DK, Wortsman J. Effect of obesity on the clinical and hormonal characteristics of the polycystic ovary syndrome. J Reprod Med. 1994;39:805–808
  18. Holte J, Bergh T, Gennarelli G, Wide L. The independent effects of polycystic ovary syndrome and obesity on serum concentrations of gonadotrophins and sex steroids in premenopausal women. Clin Endocrinol. 1994;41:473–481
  19. Schmidt JB, Spona J, Huber J. Androgen receptor in hirsutism and acne. Gynecol Obstet Invest. 1986;22:206–211
  20. Seirafi H, Farnaghi F, Vasheghani-Farahani A, Alirezaie NS, Esfahanian F, Firooz A, et al. Assessment of androgens in women with adult-onset acne. Int J Dermatol. 2007;46:1188–1191
  21. Franks S, Kiddy D, Sharp P, Singh A, Reed M, Seppala M, et al. Obesity and polycystic ovary syndrome. Ann N Y Acad Sci. 1991;626:201–206
  22. Bernasconi D, Del Monte P, Meozzi M, Randazzo M, Marugo A, Badaracco B, et al. The impact of obesity on hormonal parameters in hirsute and nonhirsute women. Metabolism. 1996;45:72–75
  23. Lin JF, Li X, Zhu MW. Exploration of the classification of polycystic ovarian syndrome. Zhonghua Fu Chan Ke Za Zhi. 2006;41:684–688
  24. Botwood N, Hamilton-Fairley D, Kiddy D, Robinson S, Franks S. Sex hormone–binding globulin and female reproductive function. J Steroid Biochem Mol Biol. 1995;53:529–531
  25. Gambineri A, Pelusi C, Manicardi E, Vicennati V, Cacciari M, Morselli-Labate AM, et al. Glucose intolerance in a large cohort of Mediterranean women with polycystic ovary syndrome: phenotype and associated factors. Diabetes. 2004;53:2353–2358
  26. Toscano V, Balducci R, Bianchi P, Guglielmi R, Mangiantini A, Rossi FG, et al. Two different pathogenetic mechanisms may play a role in acne and in hirsutism. Clin Endocrinol (Oxf). 1993;39:551–556
  27. Samojlik E, Kirschner MA, Silber D, Schneider G, Ertel NH. Elevated production and metabolic clearance rates of androgens in morbidly obese women. J Clin Endocrinol Metab. 1984;59:949–954
  28. Kirschner MA, Samojlik E, Silber D. A comparison of androgen production and clearance in hirsute and obese women. J Steroid Biochem Mol Biol. 1983;19:607–614
  29. Cohen PG. Aromatase, adiposity, aging and disease. The hypogonadal-metabolic-atherogenic-disease and aging connection. Med Hypoth. 2001;56:702–708
  30. Wake DJ, Strand M, Rask E, Westerbacka J, Livingstone DE, Soderberg S, et al. Intra-adipose sex steroid metabolism and body fat distribution in idiopathic human obesity. Clin Endocrinol (Oxf). 2007;66:440–446
  31. Chen W, Thiboutot D, Zouboulis CC. Cutaneous androgen metabolism: basic research and clinical perspectives. J Invest Dermatol. 2002;119:992–1007
  32. Martínez-Bermejo E, Luque-Ramírez M, Escobar-Morreale HF. Obesity and the polycystic ovary syndrome. Minerva Endocrinol. 2007;32:129–140

 T.-H.L. has nothing to disclose. J.-H.Y. has nothing to disclose. C.-H.H. has nothing to disclose. C.-Y.L. has nothing to disclose. C.-S.H. has nothing to disclose. M.-I.H. has nothing to disclose.

PII: S0015-0282(08)03866-1

doi: 10.1016/j.fertnstert.2008.09.003

Fertility and Sterility
Volume 92, Issue 6 , Pages 1960-1965 , December 2009

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