Fertility and Sterility
Volume 93, Issue 1 , Pages 239-250 , 1 January 2010

Gene therapy targeting leiomyoma: adenovirus-mediated delivery of dominant-negative estrogen receptor gene shrinks uterine tumors in Eker rat model

  • Memy H. Hassan, M.Sc.

      Affiliations

    • Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas
    • Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
    • ,
  • Salama A. Salama, Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas
    • ,
  • Dong Zhang, Ph.D.

      Affiliations

    • Department of Carcinogenesis, M. D. Anderson Cancer Center, University of Texas, Texas
    • Center for Women Health Research, Department of Obstetrics and Gynecology, Meharry Medical College, Nashville, Tennessee
    • ,
  • Hossam M.M. Arafa, Ph.D.

      Affiliations

    • Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
    • ,
  • Farid M.A. Hamada, Ph.D.

      Affiliations

    • Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
    • ,
  • Hala Fouad, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas
    • ,
  • Cheryl C. Walker, Ph.D.

      Affiliations

    • Department of Carcinogenesis, M. D. Anderson Cancer Center, University of Texas, Texas
    • ,
  • Ayman Al-Hendy, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas
    • Center for Women Health Research, Department of Obstetrics and Gynecology, Meharry Medical College, Nashville, Tennessee
    • Corresponding Author InformationReprint requests: Ayman Al-Hendy, Professor and Vice Chair, Center for Women Health Research, Department of Obstetrics and Gynecology, Meharry Medical College, 1005 Dr. D. B. Todd Jr. Blvd., Nashville, Tennessee 37208 (FAX: 615-963-3125).

Received 6 September 2008 ,Revised 23 September 2008 ,Accepted 30 September 2008.

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 M.H. has nothing to disclose. S.S. has nothing to disclose. D.Z. has nothing to disclose. H.A. has nothing to disclose. F.H. has nothing to disclose. H.F. has nothing to disclose. C.W. has nothing to disclose. A.A.-H. has nothing to disclose.

 Supported by National Institutes of Health/National Institute of Child Health and Human Development grant no. R01 HD046228-01.

PII: S0015-0282(08)04127-7

doi: 10.1016/j.fertnstert.2008.09.086

Fertility and Sterility
Volume 93, Issue 1 , Pages 239-250 , 1 January 2010

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