Fertility and Sterility
Volume 93, Issue 3 , Pages 762-768 , February 2010

Ovarian cryopreservation and transplantation for fertility preservation for medical indications: report of an ongoing experience

  • Kutluk Oktay, M.D., F.A.C.O.G.

      Affiliations

    • Corresponding Author InformationReprint requests: Kutluk Oktay, M.D., F.A.C.O.G., Institute for Fertility Preservation, 21 East 69 Street, New York, NY 10021 (FAX: 212-994-4499).
    • ,
  • Ozgur Oktem, M.D.

Received 17 April 2008 ,Revised 28 September 2008 ,Accepted 3 October 2008.

References 

  1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin. 2007;57:43–66
  2. Lee SJ, Schover LR, Partridge AH, Patrizio P, Wallace WH, Hagerty K, et al. American Society of Clinical Oncology. American Society of Clinical Oncology recommendations on fertility preservation in cancer patients. J Clin Oncol. 2006;24:2917–2931
  3. Annual Report of President's Cancer Panel 2005–2006. Available at: http://deainfo.nci.nih.gov/advisory/pcp/pcp06rpt/pcp06rpt.pdf. Accessed on 17 April 2008.
  4. Oktay K, Cil AP, Bang H. Efficiency of oocyte cryopreservation: a meta-analysis. Fertil Steril. 2006;86:70–80
  5. Oktay K, Newton H, Aubard Y, Salha O, Gosden RG. Cryopreservation of immature human oocytes and ovarian tissue: an emerging technology?. Fertil Steril. 1998;69:1–7
  6. Oktay K, Karlikaya G. Ovarian function after transplantation of frozen, banked autologous ovarian tissue. N Engl J Med. 2000;342:1919
  7. Oktay K, Buyuk E, Veeck L, Zaninovic N, Xu K, Takeuchi T, et al. Embryo development after heterotopic transplantation of cryopreserved ovarian tissue. Lancet. 2004;363:837–840
  8. Oktay K. Spontaneous conceptions and live birth after heterotopic ovarian transplantation: is there a germline stem cell connection?. Hum Reprod. 2006;21:1345–1348
  9. Donnez J, Dolmans MM, Demylle D, Jadoul P, Pirard C, Squifflet J, et al. Live birth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet. 2004;364:1405–1410
  10. Meirow D, Levron J, Eldar-Geva T, Hardan I, Fridman E, Zalel Y, et al. Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy. N Engl J Med. 2005;353:318–321
  11. Oktay K, Buyuk E. The technique of ovarian transplantation: laboratory and clinical aspects. In:  Patrizio P,  Tucker MJ,  Guelman V editor. A color atlas for human assisted reproduction: laboratory and clinical insights. Lippincott Williams & Wilkins: Hagerstown, MD; 2003;p. 229–241
  12. Oktay K, Karlikaya GG, Aydin BA. Ovarian cryopreservation and transplantation: basic aspects. Mol Cell Endocrinol. 2000;169:105–108
  13. Oktem O, Paduch DA, Xu K, Mielnik A, Oktay K. Normal female phenotype and ovarian development despite the ovarian expression of sex determining region of Y chromosome (SRY) in a 46, XX/69, XXY diploid/triploid mosaic child conceived after IVF-ICSI. J Clin Endocrinol Metab. 2007;92:1008–1014
  14. Oktay K, Tilly J. Live birth after cryopreserved ovarian tissue autotransplantation. Lancet. 2004;364:2091–2092
  15. Demeestere I, Simon P, Buxant F, Robin V, Fernandez SA, Centner J, et al. Ovarian function and spontaneous pregnancy after combined heterotopic and orthotopic cryopreserved ovarian tissue transplantation in a patient previously treated with bone marrow transplantation: case report. Hum Reprod. 2006;21:2010–2014
  16. Oktay K, Oktem O. Regeneration of oocytes after chemotherapy: connecting the evidence from mouse to human. J Clin Oncol. 2007;25:3185–3187

 K.O. has nothing to disclose. O.O. has nothing to disclose.

PII: S0015-0282(08)04133-2

doi: 10.1016/j.fertnstert.2008.10.006

Fertility and Sterility
Volume 93, Issue 3 , Pages 762-768 , February 2010

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