Fertility and Sterility
Volume 93, Issue 3 , Pages 706-715 , February 2010

Endometrial stromal cells from women with endometriosis reveal peculiar migratory behavior in response to ovarian steroids

  • Davide Gentilini, Ph.D.

      Affiliations

    • Molecular Biology Laboratory, Istituto Auxologico Italiano, Milan, Italy
    • Università degli Studi di Milano, Milan, Italy
    • ,
  • Paola Vigano, Ph.D.

      Affiliations

    • Università degli Studi di Milano, Milan, Italy
    • ,
  • Edgardo Somigliana, M.D.

      Affiliations

    • Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    • ,
  • Lucia Maria Vicentini, M.D.

      Affiliations

    • Università degli Studi di Milano, Milan, Italy
    • Department of Pharmacology, School of Medicine, Milan, Italy
    • ,
  • Michele Vignali, M.D.

      Affiliations

    • Università degli Studi di Milano, Milan, Italy
    • Ospedale Macedonio Melloni, Milan, Italy
    • ,
  • Mauro Busacca, M.D.

      Affiliations

    • Università degli Studi di Milano, Milan, Italy
    • Ospedale Macedonio Melloni, Milan, Italy
    • ,
  • Anna Maria Di Blasio, M.D.

      Affiliations

    • Molecular Biology Laboratory, Istituto Auxologico Italiano, Milan, Italy
    • Corresponding Author InformationReprint requests: Anna Maria Di Blasio, M.D., Istituto Auxologico Italiano, Via Zucchi 18, Cusano Milanino, Milan, Italy (FAX: +39-02-619113033).

Received 15 March 2008 ,Revised 11 September 2008 ,Accepted 10 October 2008.

References 

  1. Sampson JA. Peritoneal endometriosis due to the menstrual dissemination of endometrial tissues into the peritoneal cavity. Am J Obstet Gynecol. 1927;14:422–469
  2. Alessandro R, Kohn EC. Signal transduction targets in invasion. Clin Exp Metastasis. 2002;19:265–273
  3. Friedl P, Wolf K. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer. 2003;3:362–374
  4. Mareel M, Leroy A. Clinical, cellular, and molecular aspects of cancer invasion. Physiol Rev. 2003;83:337–376
  5. Witz CA, Thomas MR, Montoya-Rodriguez IA, Nair AS, Centonze VE, Schenken RS. Short-term culture of peritoneum explants confirms attachment of endometrium to intact peritoneal mesothelium. Fertil Steril. 2001;75:385–390
  6. Debrock S, Vander Perre S, Meuleman C, Moerman P, Hill JA, D'Hooghe TM. In-vitro adhesion of endometrium to autologous peritoneal membranes: effect of the cycle phase and the stage of endometriosis. Hum Reprod. 2002;17:2523–2528
  7. Lessey BA, Damjanovich L, Coutifaris C, Castelbaum A, Albelda SM, Buck CA. Integrin adhesion molecules in the human endometrium. Correlation with the normal and abnormal menstrual cycle. J Clin Invest. 1992;90:188–195
  8. Starzinski-Powitz A, Handrow-Metzmacher H, Kotzian S. The putative role of cell adhesion molecules in endometriosis: can we learn from tumour metastasis?. Mol Med Today. 1999;5:304–309
  9. Gaetje R, Kotzian S, Herrmann G, Baumann R, Starzinski-Powitz A. Nonmalignant epithelial cells, potentially invasive in human endometriosis, lack the tumour suppressor molecule E-cadherin. Am J Pathol. 1997;150:461–467
  10. Martelli M, Campana A, Bischof P. Secretion of matrix metallo proteinases by human endometrial cells in vitro. J Reprod Fertil. 1993;98:67–76
  11. Harada T, Kaponis A, Iwabe T, Taniguchi F, Makrydimas G, Sofikitis N, et al. Apoptosis in human endometrium and endometriosis. Hum Reprod Update. 2004;10:29–38
  12. Gentilini D, Busacca M, Di Francesco S, Vignali M, Viganò P, Di Blasio AM. PI3K/Akt and ERK1/2 signaling pathways are involved in endometrial cell migration induced by 17β-estradiol and growth factors. Mol Hum Reprod. 2007;13:317–322
  13. Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril. 1997;67:817–821
  14. Viganò P, Gaffuri B, Somigliana E, Busacca M, Di Blasio AM, Vignali M. Expression of intercellular adhesion molecule (ICAM)-1 mRNA and protein is enhanced in endometriosis versus endometrial stromal cells in culture. Mol Hum Reprod. 1998;4:1150–1156
  15. Viganò P, Somigliana E, Gaffuri B, Santorsola R, Busacca M, Vignali M. Endometrial release of soluble intercellular adhesion molecule 1 and endometriosis: relationship to the extent of the disease. Obstet Gynecol. 2000;95:115–118
  16. Heath JP, Holifield BF. On the mechanisms of cortical actin flow and its role in cytoskeletal organisation of fibroblasts. Symp Soc Exp Biol. 1993;47:35–56
  17. Heath JP. Behaviour and structure of the leading lamella in moving fibroblasts. J Cell Sci. 1983;60:331–354
  18. Simoncini T, Scorticati C, Mannella P, Fadiel A, Giretti MS, Fu XD, et al. Estrogen receptor alpha interacts with Galpha13 to drive actin remodeling and endothelial cell migration via the RhoA/Rho kinase/moesin pathway. Mol Endocrinol. 2006;20:1756–1771
  19. Small JV, Rottner K, Kaverina I, Anderson KI. Assembling an actin cytoskeleton for cell attachment and movement. Biochim Biophys Acta. 1998;1404:271–281
  20. Hotulainen P, Lappalainen P. Stress fibers are generated by two distinct actin assembly mechanisms in motile cells. J Cell Biol. 2006;173:383–394
  21. Buccione R, Orth JD, McNiven MA. Foot and mouth: podosomes invadopodia and circular dorsal ruffles. Nat Rev. 2004;5:647–657
  22. Mote PA, Bartow S, Tran N, Clarke CL. Loss of co-ordinate expression of progesterone receptors A and B is an early event in breast carcinogenesis. Breast Cancer Res Treat. 2002;72:163–172
  23. McGowan EM, Weinberger RP, Graham JD, Hill HD, Hughes JA, O'Neill GM, et al. Cytoskeletal responsiveness to progestins is dependent on progesterone receptor. A levels J Mol Endocrinol. 2003;31:241–253
  24. Wu Y, Strawn E, Basir Z, Halverson G, Guo SW. Promoter hypermethylation of progesterone receptor isoform B (PR-B) in endometriosis. Epigenetics. 2006;1:106–111
  25. Attia GR, Zeitoun K, Edwards D, Johns A, Carr BR, Bulun SE. Progesterone receptor isoform A but not B is expressed in endometriosis. J Clin Endocrinol Metab. 2000;85:2897–2902
  26. Igarashi TM, Bruner-Tran KL, Yeaman GR, Lessey BA, Edwards DP, Eisenberg E, et al. Reduced expression of progesterone receptor B in the endometrium of women with endometriosis and in cocultures of endometrial cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fertil Steril. 2005;84:67–74
  27. Lin VC, Ng EH, Aw SE, Tan MG, Ng EH, Bay BH. Progesterone induces focal adhesion in breast cancer cells MDA-MB-231 transfected with progesterone receptor complementary DNA. Mol Endocrinol. 2000;14:348–358
  28. Carnevale RP, Proietti CJ, Salatino M, Urtreger A, Peluffo G, Edwards DP, et al. Progestin effects on breast cancer cell proliferation, proteases activation, and in vivo development of metastatic phenotype all depend on progesterone receptor capacity to activate cytoplasmic signaling pathways. Mol Endocrinol. 2007;21:1335–1358
  29. Vallejo G, Ballaré C, Barañao JL, Beato M, Saragüeta P. Progestin activation of nongenomic pathways via cross talk of progesterone receptor with estrogen receptor beta induces proliferation of endometrial stromal cells. Mol Endocrinol. 2005;19:3023–3037

 D.G. has nothing to disclose. P.V. has nothing to disclose. E.S. has nothing to disclose. L.M.V. has nothing to disclose. M.V. has nothing to disclose. M.B. has nothing to disclose. A.M.D. has nothing to disclose.

PII: S0015-0282(08)04205-2

doi: 10.1016/j.fertnstert.2008.10.014

Fertility and Sterility
Volume 93, Issue 3 , Pages 706-715 , February 2010

Article Tools

* Image Usage & Resolution