Fertility and Sterility
Volume 93, Issue 3 , Pages 795-801 , February 2010

The expression and distribution of deoxyribonucleic acid repair and apoptosis markers in testicular germ cells of infertile varicocele patients resembles that of old fertile men

Presented in part at the 24th Annual Meeting of the European Society of Human Reproduction and Embryology, July 6–9, 2008, Barcelona, Spain.

  • Moetaz M. El-Domyati, M.D.

      Affiliations

    • Department of Dermatology, Sexually Transmitted Diseases, and Andrology, Al-Minya Faculty of Medicine, Al-Minya, Egypt
    • ,
  • Abo-Bakr M. Al-Din, M.D.

      Affiliations

    • Department of General Surgery, Al-Minya Faculty of Medicine, Al-Minya, Egypt
    • ,
  • Manal T. Barakat, M.D.

      Affiliations

    • Department of Dermatology, Sexually Transmitted Diseases, and Andrology, Al-Minya Faculty of Medicine, Al-Minya, Egypt
    • ,
  • Hasan M. El-Fakahany, M.D.

      Affiliations

    • Department of Dermatology, Sexually Transmitted Diseases, and Andrology, Al-Minya Faculty of Medicine, Al-Minya, Egypt
    • Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut
    • ,
  • Stanton Honig, M.D.

      Affiliations

    • Urology Center, New Haven, Connecticut
    • ,
  • Jiasen Xu, Ph.D.

      Affiliations

    • Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut
    • ,
  • Denny Sakkas, Ph.D.

      Affiliations

    • Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut
    • Corresponding Author InformationReprint requests: Denny Sakkas, Ph.D., Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 300 George Street, 7th Floor (Room 770H), New Haven CT 06511 (Fax: 203-785-7134).

Received 28 June 2008 ,Revised 14 October 2008 ,Accepted 17 October 2008.

References 

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  3. Saleh RA, Agarwal A, Sharma RK, Said TM, Sikka SC, Thomas AJ. Evaluation of nuclear DNA damage in spermatozoa from infertile men with varicocele. Fertil Steril. 2003;80:1431–1436
  4. Bertolla RP, Cedenho AP, Hassun Filho PA, Lima SB, Ortiz V, Srougi M. Sperm nuclear DNA fragmentation in adolescents with varicocele. Fertil Steril. 2006;85:625–628
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  16. El-Domyati M, Al-Din A, Barakat M, El-Fakahany H, Xu J, Sakkas D. Deoxyribonucleic acid repair and apoptosis in testicular germ cells of aging fertile men: the role of the poly(adenosine diphosphate-ribosyl)ation pathway. Fertil Steril. Published online 28 April 2008 [Epub ahead of print].
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  25. Evers JL, Collins JA. Assessment of efficacy of varicocele repair for male subfertility: a systematic review. Lancet. 2003;361:1849–1852
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  29. Pasqualotto FF, Lucon AM, de Goes PM, Sobreiro BP, Hallak J, Pasqualotto EB, et al. Is it worthwhile to operate on subclinical right varicocele in patients with grade II-III varicocele in the left testicle?. J Assist Reprod Genet. 2005;22:227–231
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 M.M.E. has nothing to disclose. A.-B.M.A. has nothing to disclose. M.T.B. has nothing to disclose. H.M.E. has nothing to disclose. S.H. has nothing to disclose. J.X. has nothing to disclose. D.S. is employed part time by Molecular Biometrics.

 H.M.E. is supported by a fellowship from the Egyptian Cultural and Educational Bureau.

PII: S0015-0282(08)04273-8

doi: 10.1016/j.fertnstert.2008.10.031

Fertility and Sterility
Volume 93, Issue 3 , Pages 795-801 , February 2010

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