Fertility and Sterility
Volume 93, Issue 4 , Pages 1255-1259 , 1 March 2010

Modulation of HOXA10 and other markers of endometrial receptivity by age and human chorionic gonadotropin in an endometrial explant model

  • Robin H. Fogle, M.D.

      Affiliations

    • Atlanta Center for Reproductive Medicine, Atlanta, Georgia
    • University of Southern California Keck School of Medicine, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Los Angeles, California
    • Corresponding Author InformationReprint requests: Robin H. Fogle, M.D., Atlanta Center for Reproductive Medicine, 5909 Peachtree Dunwoody Road, Suite 720, Atlanta, Georgia 30328 (FAX: 770-592-2092).
    • ,
  • Aimin Li, M.D.

      Affiliations

    • University of Southern California Keck School of Medicine, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Los Angeles, California
    • ,
  • Richard J. Paulson, M.D.

      Affiliations

    • University of Southern California Keck School of Medicine, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Los Angeles, California

Received 24 May 2008 ,Revised 14 November 2008 ,Accepted 14 November 2008.

References 

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  2. Reshef E, Lei AM, Rao CV, Pridham DD, Chegini N, Luborsky JL. The presence of gonadotropin receptors in nonpregnant human uterus, human placenta, fetal membranes, and decidua. J Clin Endocrinol Metab. 1990;70:421–430
  3. Han SW, Lei ZM, Rao CV. Treatment of human endometrial stromal cells with chorionic gonadotropin promotes their morphological and functional differentiation into decidua. Mol Cell Endocrinol. 1999;147:7–16
  4. Nemansky M, Moy E, Lyons CD, Yu I, Blithe DL. Human endometrial stromal cells generate uncombined alpha-subunit from human chorionic gonadotropin, which can synergize with progesterone to induce decidualization. J Clin Endocrinol Metab. 1998;83:575–581
  5. Fazleabas AT, Donnelly KM, Srinivasan S, Fortman JD, Miller JB. Modulation of the baboon (Papio Anubis) uterine endometrium by chorionic gonadotrophin during the period of uterine receptivity. Proc Natl Acad Sci U S A. 1999;96:2543–2548
  6. Srisuparp S, Strakova Z, Fazleabas AT. The role of chorionic gonadotropin (CG) in blastocyst implantation. Arch Med Res. 2001;32:627–634
  7. Sauer MV, Paulson RJ, Lobo RA. Reversing the natural decline in human fertility: an extended clinical trial of oocyte donation to women of advanced reproductive age. JAMA. 1992;268:1275–1279
  8. Marbaix E, Donnez J, Courtoy PJ, Eeckhout Y. Progesterone regulates the activity of collagenase and related gelatinases A and B in human endometrial explants. Proc Natl Acad Sci U S A. 1992;89:11789–11793
  9. Osteen KG, Rodgers WH, Gaire M, Hargrove JT, Gorstein F, Matrisian LM. Stromal-epithelial interaction mediates steroidal regulation of metalloproteinase expression in human endometrium. Proc Natl Acad Sci U S A. 1994;91:10129–10133
  10. Jain JK, Li A, Nucatola DL, Minoo P, Felix JC. Nonoxynol-9 induces apoptosis of endometrial explants by both caspase-dependent and independent apoptotic pathways. Biol Reprod. 2005;73:382–388
  11. Hansis C, Patel S, Stanczyk FZ, Paulson RJ. Measurement of hCG in culture media: a promising marker for selecting high-potential preimplantation human embryos. Fertil Steril. 2005;84(Suppl 1):S90
  12. Gerdes J, Lemke H, Baisch H, Wacker HH, Schwab U, Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol. 1984;133:1710–1715
  13. Jain JK, Li A, Yang W, Minoo P, Felix JC. Effects of mifepristone on proliferation and apoptosis of human endometrium in new users of medroxyprogesterone acetate. Hum Reprod. 2006;21:798–809
  14. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2- ΔΔCt method. Methods. 2001;25:402–408
  15. Dudley DJ, Hatasaka HH, Branch DW, Hammond E, Mitchell MD. A human endometrial explant system: validation and potential applications. Am J Obstet Gynecol. 1992;167:1774–1780
  16. Nucatola DL, Li A, Nicosia AF, Felix JC, Jain JK. The effect of mifepristone on estrogen receptors following treatment with medroxyprogesterone acetate in cultured human endometrial explants. Fertil Steril. 2003;80:S53
  17. Sakkas D, Lu C, Zulfikaroglu E, Neuber E, Taylor HS. A soluble molecule secreted by human blastocysts modulates regulation of HOXA10 expression in an epithelial endometrial cell line. Fertil Steril. 2003;80:1169–1174
  18. Paulson RJ, Hatch IE, Lobo RA, Sauer MV. Cumulative conception and live birth rates after oocyte donation: implications regarding endometrial receptivity. Hum Reprod. 1997;12:835–839
  19. Sauer MV, Paulson RJ, Ary BA, Lobo RA. Three hundred cycles of oocyte donation at the University of Southern California: assessing the effect of age and infertility diagnosis on pregnancy and implantation rates. J Assist Reprod Genet. 1994;11:92–96
  20. Legro RS, Wong IL, Paulson RJ, Lobo RA, Sauer MV. Recipient's age does not adversely affect pregnancy outcome after oocyte donation. Am J Obstet Gynecol. 1995;172:96–100
  21. Toner JP, Grainger DA, Frazier LM. Clinical outcomes among recipients of donated eggs: an analysis of the U.S. national experience, 1996–1998. Fertil Steril. 2002;78:1038–1045

 R.H.F. has nothing to disclose. A.L. has nothing to disclose. R.J.P. has nothing to disclose.

PII: S0015-0282(08)04547-0

doi: 10.1016/j.fertnstert.2008.11.002

Fertility and Sterility
Volume 93, Issue 4 , Pages 1255-1259 , 1 March 2010

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