Fertility and Sterility
Volume 93, Issue 4 , Pages 1088-1096, 1 March 2010

Risk factors for psychiatric disorders in infertile women and men undergoing in vitro fertilization treatment

  • Helena Volgsten, M.Sc.

      Affiliations

    • Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
    • Corresponding Author InformationReprint requests: Helena Volgsten, M.Sc., Department of Women's and Children's Health, University Hospital, 751 85 Uppsala, Sweden (FAX: +46-18-55-97-75).
    • ,
  • Agneta Skoog Svanberg, Ph.D.

      Affiliations

    • Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
    • ,
  • Lisa Ekselius, Ph.D.

      Affiliations

    • Department of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden
    • ,
  • Örjan Lundkvist, Ph.D.

      Affiliations

    • Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
    • ,
  • Inger Sundström Poromaa, Ph.D.

      Affiliations

    • Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden

Received 22 August 2008; received in revised form 10 October 2008; accepted 2 November 2008. published online 31 December 2008.

Objective

To identify risk factors associated with depression and anxiety in infertile women and men undergoing in vitro fertilization (IVF).

Design

Prospective study.

Setting

A university hospital in Sweden during a 2-year period.

Patient(s)

825 participants (413 women and 412 men).

Intervention(s)

Primary Care Evaluation of Mental Disorders (PRIME-MD), based on the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV), as the diagnostic tool for evaluating mood and anxiety disorders, and fertility history and outcome of IVF treatment collected from the patients' medical records.

Main Outcome Measure(s)

Risk factors associated with depression and anxiety disorders.

Result(s)

A negative pregnancy test and obesity were the independent risk factors for any mood disorders in women. Among men, the only independent risk factor for depression was unexplained infertility. No IVF-related risk factors could be identified for any anxiety disorder.

Conclusion(s)

A negative pregnancy test is associated with an increased risk for depression in women undergoing IVF, but no risk of developing anxiety disorders is associated with the pregnancy test result after IVF. Pregnancy test results were not a risk factor for depression or anxiety among men.

Key Words: Depression, anxiety, women, men, infertility, in vitro fertilization, risk factors

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 H.V. has nothing to disclose. A.S.S. has nothing to disclose. L.E. has nothing to disclose. Ö.L. has nothing to disclose. I.S.P. has nothing to disclose.

 Supported by research grants from the Swedish Research Council, project K2008-54X-20642-01-3, the Council for Working Life and Social Research, project 2007-1955, the Family Planning Foundation, and the Foundation of Caring Sciences, Uppsala University.

PII: S0015-0282(08)04552-4

doi:10.1016/j.fertnstert.2008.11.008

Fertility and Sterility
Volume 93, Issue 4 , Pages 1088-1096, 1 March 2010

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