Fertility and Sterility
Volume 93, Issue 4 , Pages 1088-1096 , 1 March 2010

Risk factors for psychiatric disorders in infertile women and men undergoing in vitro fertilization treatment

  • Helena Volgsten, M.Sc.

      Affiliations

    • Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
    • Corresponding Author InformationReprint requests: Helena Volgsten, M.Sc., Department of Women's and Children's Health, University Hospital, 751 85 Uppsala, Sweden (FAX: +46-18-55-97-75).
    • ,
  • Agneta Skoog Svanberg, Ph.D.

      Affiliations

    • Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
    • ,
  • Lisa Ekselius, Ph.D.

      Affiliations

    • Department of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden
    • ,
  • Örjan Lundkvist, Ph.D.

      Affiliations

    • Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
    • ,
  • Inger Sundström Poromaa, Ph.D.

      Affiliations

    • Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden

Received 22 August 2008 ,Revised 10 October 2008 ,Accepted 2 November 2008.

References 

  1. Verhaak CM, Smeenk JM, Evers AW, van Minnen A, Kremer JA, Kraaimaat FW. Predicting emotional response to unsuccessful fertility treatment: a prospective study. J Behav Med. 2005;28:181–190
  2. Volgsten H, Skoog Svanberg A, Ekselius L, Lundkvist O, Sundstrom Poromaa I. Prevalence of psychiatric disorders in infertile women and men undergoing in vitro fertilization treatment. Hum Reprod. 2008;23:2056–2063
  3. Kessler RC, McGonagle KA, Zhao S, Nelson CB, Hughes M, Eshleman S, et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry. 1994;51:8–19
  4. Kringlen E, Torgersen S, Cramer V. A Norwegian psychiatric epidemiological study. Am J Psychiatry. 2001;158:1091–1098
  5. Kringlen E, Torgersen S, Cramer V. Mental illness in a rural area: a Norwegian psychiatric epidemiological study. Soc Psychiatry Psychiatr Epidemiol. 2006;41:713–719
  6. Domar AD, Broome A, Zuttermeister PC, Seibel M, Friedman R. The prevalence and predictability of depression in infertile women. Fertil Steril. 1992;58:1158–1163
  7. Demyttenaere K, Bonte L, Gheldof M, Vervaeke M, Meuleman C, Vanderschuerem D, et al. Coping style and depression level influence outcome in in vitro fertilization. Fertil Steril. 1998;69:1026–1033
  8. Newton CR, Hearn MT, Yuzpe AA. Psychological assessment and follow-up after in vitro fertilization: assessing the impact of failure. Fertil Steril. 1990;54:879–886
  9. Sundstrom IM, Bixo M, Bjorn I, Astrom M. Prevalence of psychiatric disorders in gynecologic outpatients. Am J Obstet Gynecol. 2001;184:8–13
  10. Andersson L, Sundstrom-Poromaa I, Bixo M, Wulff M, Bondestam K, Åstrom M. Point prevalence of psychiatric disorders during the second trimester of pregnancy: a population-based study. Am J Obstet Gynecol. 2003;189:148–154
  11. Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62:617–627
  12. Baumeister H, Harter M. Prevalence of mental disorders based on general population surveys. Soc Psychiatry Psychiatr Epidemiol. 2007;42:537–546
  13. Andersson L, Sundstrom-Poromaa I, Wulff M, Astrom M, Bixo M. Implications of antenatal depression and anxiety for obstetric outcome. Obstet Gynecol. 2004;104:467–476
  14. Kessler RC. Epidemiology of women and depression. J Affect Disord. 2003;74:5–13
  15. Spitzer RL, Williams JB, Kroenke K, Linzer M, deGruy FV, Hahn SR, et al. Utility of a new procedure for diagnosing mental disorders in primary care. The PRIME-MD 1000 study. JAMA. 1994;272:1749–1756
  16. Bagley SC, White H, Golomb BA. Logistic regression in the medical literature: standards for use and reporting, with particular attention to one medical domain. J Clin Epidemiol. 2001;54:979–985
  17. Hosmer D, Lemeshow S. Applied logistic regression. 2nd ed. New York: Wiley Interscience; 2000;
  18. Verhaak CM, Smeenk JM, Evers AW, Kremer JA, Kraaimaat FW, Braat DD. Women's emotional adjustment to IVF: a systematic review of 25 years of research. Hum Reprod Update. 2006;13:27–36
  19. Verhaak CM, Smeenk JM, Eugster A, van Minnen A, Kremer JA, Kraaimaat FW. Stress and marital satisfaction among women before and after their first cycle of in vitro fertilization and intracytoplasmic sperm injection. Fertil Steril. 2001;76:525–531
  20. World Health Organization. Obesity in Europe. Available at: http://www.euro.who.int/obesity. Accessed October 2008.
  21. Simon GE, Von Korff M, Saunders K, Miglioretti DL, Crane PK, van Belle G, et al. Association between obesity and psychiatric disorders in the US adult population. Arch Gen Psychiatry. 2006;63:824–830
  22. Barry D, Pietrzak RH, Petry NM. Gender differences in associations between body mass index and DSM-IV mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Ann Epidemiol. 2008;18:458–466
  23. Hollinrake E, Abreu A, Maifeld M, Van Voorhis BJ, Dokras A. Increased risk of depressive disorders in women with polycystic ovary syndrome. Fertil Steril. 2007;87:1369–1376
  24. Maheshwari A, Stofberg L, Bhattacharya S. Effect of overweight and obesity on assisted reproductive technology—a systematic review. Hum Reprod Update. 2007;13:433–444
  25. Lintsen AM, Pasker-de Jong PC, de Boer EJ, Burger CW, Jansen CA, Braat DD, et al. Effects of subfertility cause, smoking and body weight on the success rate of IVF. Hum Reprod. 2005;20:1867–1875
  26. Galletly C, Clark A, Tomlinson L, Blaney F. Improved pregnancy rates for obese, infertile women following a group treatment program. An open pilot study. Gen Hosp Psychiatry. 1996;18:192–195
  27. Homan GF, Davies M, Norman R. The impact of lifestyle factors on reproductive performance in the general population and those undergoing infertility treatment: a review. Hum Reprod Update. 2007;13:209–223
  28. Sjoholm L, Lavebratt C, Forsell Y. A multifactorial developmental model for the etiology of major depression in a population-based sample. J Affect Disord. Published online June 14, 2008.
  29. Williams KE, Marsh WK, Rasgon NL. Mood disorders and fertility in women: a critical review of the literature and implications for future research. Hum Reprod Update. 2007;13:607–616
  30. Thiering P, Beaurepaire J, Jones M, Saunders D, Tennant C. Mood state as a predictor of treatment outcome after in vitro fertilization/embryo transfer technology (IVF/ET). J Psychosom Res. 1993;37:481–491
  31. Facchinetti F, Matteo ML, Artini GP, Volpe A, Genazzani AR. An increased vulnerability to stress is associated with a poor outcome of in vitro fertilization–embryo transfer treatment. Fertil Steril. 1997;67:309–314
  32. Smeenk JM, Verhaak CM, Eugster A, van Minnen A, Zielhuis GA, Braat DD. The effect of anxiety and depression on the outcome of in-vitro fertilization. Hum Reprod. 2001;16:1420–1423
  33. Slade P, Emery J, Lieberman BA. A prospective, longitudinal study of emotions and relationships in in-vitro fertilization treatment. Hum Reprod. 1997;12:183–190
  34. Milad MP, Klock SC, Moses S, Chatterton R. Stress and anxiety do not result in pregnancy wastage. Hum Reprod. 1998;13:2296–2300
  35. Ardenti R, Campari C, Agazzi L, La Sala GB. Anxiety and perceptive functioning of infertile women during in-vitro fertilization: exploratory survey of an Italian sample. Hum Reprod. 1999;14:3126–3132
  36. Klonoff-Cohen H, Chu E, Natarajan L, Sieber W. A prospective study of stress among women undergoing in vitro fertilization or gamete intrafallopian transfer. Fertil Steril. 2001;76:675–687
  37. de Klerk C, Hunfeld JA, Heijnen EM, Eijkemans MJ, Fauser BC, Passchier J, et al. Low negative affect prior to treatment is associated with a decreased chance of live birth from a first IVF cycle. Hum Reprod. 2008;23:112–116

 H.V. has nothing to disclose. A.S.S. has nothing to disclose. L.E. has nothing to disclose. Ö.L. has nothing to disclose. I.S.P. has nothing to disclose.

 Supported by research grants from the Swedish Research Council, project K2008-54X-20642-01-3, the Council for Working Life and Social Research, project 2007-1955, the Family Planning Foundation, and the Foundation of Caring Sciences, Uppsala University.

PII: S0015-0282(08)04552-4

doi: 10.1016/j.fertnstert.2008.11.008

Fertility and Sterility
Volume 93, Issue 4 , Pages 1088-1096 , 1 March 2010

Article Tools