Fertility and Sterility
Volume 93, Issue 4 , Pages 1244-1247 , 1 March 2010

Association study of vascular endothelial growth factor polymorphisms with the risk of recurrent spontaneous abortion

  • Hyun Haing Lee, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, College of Medicine, Pochon CHA University, Seongnam, South Korea
    • Institute for Clinical Research, College of Medicine, Pochon CHA University, Seongnam, South Korea
    • Hyun Haing Lee and Seung Ho Hong contributed equally to this work.
  • ,
  • Seung Ho Hong, Ph.D.

      Affiliations

    • Department of Science Education, Teachers College, Cheju National University, Jeju, South Korea
    • Hyun Haing Lee and Seung Ho Hong contributed equally to this work.
  • ,
  • Seung Ju Shin, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, College of Medicine, Pochon CHA University, Seongnam, South Korea
  • ,
  • Jung Jae Ko, Ph.D.

      Affiliations

    • CHA Research Institute, College of Medicine, Pochon CHA University, Seongnam, South Korea
  • ,
  • Doyeun Oh, M.D.

      Affiliations

    • Institute for Clinical Research, College of Medicine, Pochon CHA University, Seongnam, South Korea
  • ,
  • Nam Keun Kim, Ph.D.

      Affiliations

    • Institute for Clinical Research, College of Medicine, Pochon CHA University, Seongnam, South Korea
    • Corresponding Author InformationReprint requests: Nam Keun Kim, Ph.D., Institute for Clinical Research, Bundang CHA General Hospital, College of Medicine, Pochon CHA University, 351 Yatap-dong, Bundang-gu, Seongnam 463-712, South Korea (TEL: +82-31-780-5762; FAX: +82-31-780-5766).

Received 17 July 2008 ,Revised 15 October 2008 ,Accepted 20 November 2008.

References 

  1. Younis JS, Ohel G, Brenner B, Ben-Ami M. Familial thrombophilia—the scientific rationale for thrombophylaxis in recurrent pregnancy loss?. Hum Reprod. 1997;12:1389–1390
  2. Raziel A, Kornberg Y, Fridler S, Schachter M, Sela BA, Ron-El R. Hypercoagulable thrombothilic defects and hyperhomocysteinemia in patients with recurrent pregnancy loss. Am J Reprod Immunol. 2001;45:65–71
  3. Yamada H, Kato EH, Kobashi G, Ebina Y, Shimada S, Morikawa M, et al. Recurrent pregnancy loss: etiology of thrombophilia. Semin Thromb Hemost. 2001;27:121–129
  4. Li TC, Makris M, Tomsu M, Tuckerman E, Laird S. Recurrent miscarriage: aetiology, management and prognosis. Hum Reprod Update. 2002;8:463–481
  5. Iruela-Arispe ML, Dvorak HF. Angiogenesis: a dynamic balance of stimulators and inhibitors. Thromb Haemost. 1997;78:672–677
  6. Senger DR, Van de Water L, Brown LF, Nagy JA, Yeo KT, Teo TK, et al. Vascular permeability factor (VPF, VEGF) in tumor biology. Cancer Metastasis Rev. 1993;12:303–324
  7. Lin CC, Wu HC, Tsai FJ, Chen HY, Chen WC. Vascular endothelial growth factor gene –460 C/T polymorphism is a biomarker for prostate cancer. Urology. 2003;62:374–377
  8. Lu H, Shu X-O, Cui Y, Kataoka N, Wen W, Cai Q, et al. Association of genetic polymorphisms in the VEGF gene with breast cancer survival. Cancer Res. 2005;65:5015–5019
  9. Sharkey AM, Charnock JD, Boocock CA, Brown KD, Smith SK. Expression of mRNA for vascular endothelial growth factor in human placenta. J Repord Fertil. 1993;99:609–615
  10. Zhang Z, Chopp M. Vascular endothelial growth factor and angiopoietins in focal cerebral ischemia. Trends Cardiovasc Med. 2002;12:62–66
  11. Ladoux A, Frelin C. Expression of vascular endothelial growth factor by cultured endothelial cells from brain microvessels. Biochem Biophys Res Commun. 1993;194:799–803
  12. Lambrechts D, Storkebaum E, Morimoto M, Del-Favero J, Desmet F, Marklund S, et al. VEGF in a modifier of amyotrophic lateral sclerosis in mice and humans and proects motoneurons against ischemic death. Nat Genet. 2003;34:383–394
  13. Shahbazi M, Fryer AA, Pravica V, Brogan IJ, Ramsay HM, Hutchinson IV, et al. Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejection. J Am Soc Nephrol. 2002;13:260–264
  14. Tischer E, Mitchell R, Harrman T, Silva M, Gospodarowicz D, Fiddes JC, et al. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem. 1991;266:11947–11954
  15. Papazoglou D, Galazios G, Papatheodorou K, Liberis V, Papanas N, Maltezos E, et al. Vascular endothelial growth factor gene polymorphisms and idiopathic recurrent pregnancy loss. Fertil Steril. 2005;83:959–963
  16. Del Bo R, Scarlato M, Ghezzi S, Martinelli F, Boneschi M, Fenoglio C, et al. Vascular endothelial growth factor gene variability is associated with increased risk for AD. Ann Neurol. 2005;57:373–380
  17. Papazoglou D, Galazios G, Koukourakis MI, Kontomanolis EN, Maltezos E. Association of –634G/C and 936C/T polymorphisms of the vascular endothelial growth factor with spontaneous preterm delivery. Acta Obstet Gynecol Scand. 2004;83:461–465
  18. Chapuis J, Tian J, Shi J, Bensemain F, Cottel D, Lendon C, et al. Association study of the vascular endothelial growth factor gene with the risk of developing Alzheimer disease. Neurobio Aging. 2006;27:1212–1215
  19. Jin Q, Hemminki K, Enquist K, Lenner P, Grzybowska E, Klaes R, et al. Vascular endothelial growth factor polymorphisms in relation to breast cancer development and prognosis. Hum Can Biol. 2005;11:3647–3653
  20. Jacobs EJ, Feigelson HS, Bain EB, Brady KA, Rodriguez C, Stevens VL, et al. Polymorphisms in the vascular endothelial growth factor gene and breast cancer in the cancer prevention study II cohort. Breast Cancer Res. 2005;8:R22
  21. Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature. 1996;380:435–439
  22. Coulam CB, Jeyendran RS. Vascular endothelial growth factor gene polymorphisms and recurrent pregnancy loss. Am J Reprod Immunol. 2008;59:301–305
  23. Goodman C, Jeyendran RS, Coulam CB. P53 tumor suppressor factor, plasminogen activator inhibitor, and vascular endothelial growth factor gene polymorphisms and recurrent implantation failure. Fertil Steril. In press.
  24. Goodman C, Jeyendran RS, Coulam CB. Vascular endothelial growth factor gene polymorphisms and implantation failure. Reprod Biomed Online. 2008;16:720–723
  25. Brogan IJ, Khan N, Isaac K, Hutchinson JA, Pravica V, Hutchinson IV. Novel polymorphism in the promoter and 5′ UTR regions of the human vascular endothelial growth factor gene. Hum Immunol. 1999;60:1245–1249
  26. Mohammadi M, Ollier WE, Hutchinson IV. A functional association study of VEGF gene promoter polymorphism with VEGF expression by stimulated pbm cells. Hum Immunol. 2003;64(Suppl):S125
  27. Watson CJ, Webb NJA, Bottomley MJ, Brenchley PEC. Identification of polymorphisms within the vascular endothelial growth factor gene: correlation with variation in VEGF protein production. Cytokine. 2000;12:1232–1235
  28. Howell WM, Bateman AC, Turner SJ, Collins A, Theaker JM. Influence of vascular endothelial growth factor single nucleotide polymorphisms on tumour development in cutaneous malignant melanoma. Genes Immunol. 2002;3:229–232

 H.H.L has nothing to disclose. S.H.H. has nothing to disclose. S.J.S. has nothing to disclose. J.J.K. has nothing to disclose. D.O. has nothing to disclose. N.K.K. has nothing to disclose.

 This work was supported by a grant from the Korea Research Foundation of the Korean Government (MOEHRD) (KRF-2005-041-E00360 & KRF-2006-331-E00304).

PII: S0015-0282(08)04591-3

doi: 10.1016/j.fertnstert.2008.11.017

Fertility and Sterility
Volume 93, Issue 4 , Pages 1244-1247 , 1 March 2010