Fertility and Sterility
Volume 93, Issue 4 , Pages 1299-1307 , 1 March 2010

Protective effects of telmisartan on ischemia/reperfusion injury of rat ovary: biochemical and histopathologic evaluation

  • Yakup Kumtepe, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Ataturk University School of Medicine, Erzurum, Turkey
    • Corresponding Author InformationReprint requests: Dr. Yakup Kumtepe, Obstetrics and Gynecology, Faculty of Medicine, Ataturk University, Terminal cad no. 14/2, 25200 Erzurum, Turkey (FAX: +90 442 236 0968).
  • ,
  • Fehmi Odabasoglu, Ph.D.

      Affiliations

    • Department of Biochemistry, Ataturk University School of Pharmacy, Erzurum, Turkey
  • ,
  • Mehmet Karaca, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Kafkas University School of Medicine, Kars, Turkey
  • ,
  • Beyzagul Polat, M.Sc.

      Affiliations

    • Department of Pharmacology, Ataturk University School of Medicine, Erzurum, Turkey
  • ,
  • Mesut Bünyamin Halici, Ph.D.

      Affiliations

    • Department of Biochemistry, Ataturk University School of Pharmacy, Erzurum, Turkey
  • ,
  • Osman Nuri Keles, M.Sc.

      Affiliations

    • Department of Histology and Embryology, Ataturk University School of Medicine, Erzurum, Turkey
  • ,
  • Zuhal Altunkaynak, Ph.D.

      Affiliations

    • Department of Histology and Embryology, Ataturk University School of Medicine, Erzurum, Turkey
  • ,
  • Fatma Gocer, M.D.

      Affiliations

    • Department of Pharmacology, Ataturk University School of Medicine, Erzurum, Turkey

Received 1 August 2008 ,Revised 28 November 2008 ,Accepted 8 December 2008.

References 

  1. Haskins T, Shull B. Adnexal torsion: a mind-twisted diagnosis. South Med J. 1986;79:576–577
  2. Chen M, Chen CD, Yang YS. Torsion of the previously normal uterine adnexa. Evaluation of the correlation between the pathological changes and the clinical characteristics. Acta Obstet Gynecol Scand. 2001;80:58–61
  3. Kuroda S, Siesjo BK. Reperfusion damage following focal ischemia: pathophysiology and therapeutic windows. Clin Neurosci. 1997;4:199–212
  4. Abumiya T, Fitridge R, Mazur C, Copeland BR, Koziol JA, Tschopp JF, et al. Integrin alpha(IIb)beta(3) inhibitor preserves microvascular patency in experimental acute focal cerebral ischemia. Stroke. 2000;31:1402–1409
  5. Bird JE, Milhoan K, Wilson CB, Young SG, Mundy CA, Parthasarathy S, et al. Ischemic acute renal failure and antioxidant therapy in the rat: the relation between glomerular and tubular dysfunction. J Clin Invest. 1988;81:1630–1638
  6. Baker GL, Corry RJ, Autor AP. Oxygen free radical induced damage in kidneys subjected to warm ischemia and reperfusion: protective effect of superoxide dismutase. Ann Surg. 1985;202:628–641
  7. McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med. 1985;312:159–163
  8. Lipton P. Ischemic cell death in brain neurons. Physiol Rev. 1999;79:1431–1568
  9. Mogilner JG, Lurie M, Coran AG, Nativ O, Shiloni E, Sukhotnik I. Effect of diclofenac on germ cell apoptosis following testicular ischemia-reperfusion injury in a rat. Pediatr Surg Int. 2006;22:99–105
  10. Turkoz Y, Celik O, Hascalik S, Cigremis Y, Hascalik M, Mizrak B, et al. Melatonin reduces torsion-detorsion injury in rat ovary: biochemical and histopathologic evaluation. J Pineal Res. 2004;37:137–141
  11. Hahn AWA, Jonas U, Buhler FR, Resink TJ. Activation of human peripheral monocytes by angiotensin II. FEBS Lett. 1994;347:178–180
  12. Han Y, Runge MA, Brasier AR. Angiotensin II induces Il-6 transcription in vascular smooth muscle cells through pleiotropic activation of NF-kB transcription factors. Circ Res. 1999;84:695–703
  13. Schieffer B, Schieffer E, Hilfiker-Kleiner D, Hilfiker A, Kovanen PT, Kaartinen M, et al. Expression of angiotensin II and interleukin 6 in human coronary atherosclerotic plaques: potential implications for inflammation and plaque instability. Circulation. 2000;101:1372–1378
  14. Kalra D, Sivasubramanian N, Mann DL. Angiotensin II induces tumor necrosis factor biosynthesis in the adult mammalian heart through a protein kinase C–dependent pathway. Circulation. 2002;105:2198–2205
  15. Nickenig G, Harrison DG. The AT(1)-type angiotensin receptor in oxidative stress and atherogenesis: part I: oxidative stress and atherogenesis. Circulation. 2002;105:393–396
  16. Nickenig G, Harrison DG. The AT(1)-type angiotensin receptor in oxidative stress and atherogenesis: part II: AT(1) receptor regulation. Circulation. 2002;105:530–536
  17. Zhang H, Schmeisser A, Garlichs CD, Plotze K, Damme U, Mugge A, et al. Angiotensin II-induced superoxide anion generation in human vascular endothelial cells: role of membrane-bound NADH/NADPH-oxidases. Cardiovasc Res. 1999;44:215–222
  18. Vazquez-Oliva G, Fernandez-Real JM, Zamora A, Vilaseca M, Badimon L. Lowering of blood pressure leads to decreased circulating interleukin-6 in hypertensive patients. J Hum Hypertens. 2005;19:457–462
  19. Takaya T, Kawashima S, Shinohara M, Yamashita T, Toh R, Sasaki N, et al. Angiotensin II type 1 receptor blocker telmisartan suppresses superoxide production and reduces atherosclerotic lesion formation in apolipoprotein E–deficient mice. Atherosclerosis. 2006;186:402–410
  20. Schmieder RE. Endothelial dysfunction: how can one intervene at the beginning of the cardiovascular continuum?. J Hypertens. 2006;24:S31–S35
  21. Takai S, Kirimura K, Jin D, Muramatsu M, Yoshikawa K, Mino Y, et al. Significance of angiotensin II receptor blocker lipophilicities and their protective effect against vascular remodeling. Hypertens Res. 2005;28:593–600
  22. Kajihara N, Nishida T, Boku N, Tatewaki H, Eto M, Morita S. Angiotensin II type 1 receptor antagonist protects ventricular and coronary endothelial function after 24-hour heart preservation. J Heart Lung Transplant. 2005;24:2211–2217
  23. Taskin O, Birincioglu M, Aydin A, Buhur A, Burak F, Yilmaz I, et al. The effects of twisted ischaemic adnexa managed by detorsion on ovarian viability and histology: an ischaemia-reperfusion rodent model. Hum Reprod. 1998;13:2823–2827
  24. Bradley PP, Priebat DA, Christensen RD, Rothstein G. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol. 1982;78:206–209
  25. Sun Y, Larry WO, Ying L. A simple method for clinical assay of superoxide dismutase. Clin Chem. 1988;34:497–500
  26. Feelisch M, Noack EA. Correlation between nitric oxide formation during degredation of organic nitrates and activation of guanylate cyclase. Eur J Pharmacol. 1987;139:19–30
  27. Knowles RG, Merrett M, Salter M, Moncada S. Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat. Biochem J. 1990;270:833–836
  28. Liou KT, Shen YC, Chen CF, Taso CM, Tsai SK. Honokiol protects rat brain from focal cerebral ischemia-reperfusion injury by inhibiting neutrophil infiltration and reactive oxygen species production. Brain Res. 2003;992:159–166
  29. Halici Z, Karaca M, Keles ON, Borekci B, Odabasoglu F, Suleyman H, et al. Protective effects of amlodipine on ischemia-reperfusion injury of rat ovary: biochemical and histopathologic evaluation. Fertil Steril. 2008;90:2408–2415
  30. Wink DA, Hanbauer I, Krishna MC, DeGraff W, Gamson J, Mitchell JB. Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species. Proc Natl Acad Sci U S A. 1993;90:9813–9817
  31. Wink DA, Miranda KM, Espey MG, Pluta RM, Hewett SJ, Colton C, et al. Mechanisms of the antioxidant effects of nitric oxide. Antioxid Redox Signal. 2001;3:203–221
  32. Chatterjee PK, Patel NS, Kvale EO, Cuzzocrea S, Brown PA, Stewart KN, et al. Inhibition of inducible nitric oxide synthase reduces renal ischemia/reperfusion injury. Kidney Int. 2002;61:862–871
  33. Sugino N, Nakamura Y, Okuno N, Ishimatu M, Teyama T, Kato H. Effects of ovarian ischemia-reperfusion on luteal function in pregnant rats. Biol Reprod. 1993;49:354–358
  34. Davies SJ, Reichardt-Pascal SY, Vaughan D, Russell GI. Differential effect of ischaemia-reperfusion injury on antioxidant enzyme activity in the rat kidney. Exp Nephrol. 1995;3:348–354
  35. Jassem W, Fuggle SV, Rela M, Koo DD, Heaton ND. The role of mitochondria in ischemia/reperfusion injury. Transplantation. 2002;73:493–499
  36. Dobashi K, Ghosh B, Orak JK, Singh I, Singh AK. Kidney ischemiareperfusion: modulation of antioxidant defenses. Mol Cell Biochem. 2000;205:1–11
  37. Hayek T, Attias J, Coleman R, Brodsky S, Smith J, Breslow JL, et al. The angiotensin-converting enzyme inhibitor, fosinopril, and the angiotensin II receptor antagonist, losartan, inhibit LDL oxidation and attenuate atherosclerosis independent of lowering blood pressure in apolipoprotein E–deficient mice. Cardiovasc Res. 1999;44:579–587
  38. Dol F, Martin G, Staels B, Mares AM, Cazaubon C, Nisato D, et al. Angiotensin AT1 receptor antagonist in apolipoprotein E–deficient mice. J Cardiovasc Pharmacol. 2001;38:395–405
  39. Cianchetti S, Del Fiorentino A, Colognato R, Di Stefano R, Franzoni F, Pedrinelli R. Anti-inflammatory and antioxidant properties of telmisartan in cultured human umbilical vein endothelial cells. Atherosclerosis. 2008;198:22–28
  40. Hickey MJ, Granger DN, Kubes P. Inducible nitric oxide synthase (iNOS) and regulation of leucocyte/endothelial cell interactions: studies in iNOS-deficient mice. Acta Physiol Scand. 2001;173:119–126
  41. Ozokutan BH, Kucukaydin M, Muhtaroglu S, Tekin Y. The role of nitric oxide in testicular ischemia-reperfusion injury. J Pediatr Surg. 2000;35:101–103
  42. Ferreiro CR, Chagas AC, Carvalho MH, Dantas AP, Jatene MB, Bento De Souza LC, et al. Influence of hypoxia on nitric oxide synthase activity and gene expression in children with congenital heart disease: a novel pathophysiological adaptive mechanism. Circulation. 2001;103:2272–2276
  43. Hibbs JBJ, Taintor RR, Vavrin Z, Rachlin EM. Nitric oxide: a cytotoxic activated macrophage effector molecule. Biochem Biophys Res Commun. 1998;157:87–94
  44. Lamas S, Michel T, Brenner BM, Marsden PA. Nitric oxide synthesis in endothelial cells—evidence for a pathway inducible by TNFalpha. Am J Physiol. 1991;261:C634–C641
  45. Ermert M, Ruppert C, Gunther A, Duncker HR, Seeger W, Ermert L. Cell-specific nitric oxide synthase–isoenzyme expression and regulation in response to endotoxin in intact rat lungs. Lab Invest. 2002;82:425–441

 Y.K. has nothing to disclose. F.O. has nothing to disclose. M.K. has nothing to disclose. B.P. has nothing to disclose. M.B.H. has nothing to disclose. O.N.K. has nothing to disclose. Z.A. has nothing to disclose. F.G. has nothing to disclose.

PII: S0015-0282(08)04662-1

doi: 10.1016/j.fertnstert.2008.12.016

Fertility and Sterility
Volume 93, Issue 4 , Pages 1299-1307 , 1 March 2010