Fertility and Sterility
Volume 93, Issue 4 , Pages 1157-1168 , 1 March 2010

Health of children born after ovulation induction

Some results of this study have been presented at The Nordic Meeting on Register-based Health Research, Helsinki, Finland, September 22–23, 2005.

  • Reija Klemetti, Ph.D.

      Affiliations

    • Health Services Research, STAKES, National Research and Development Centre for Welfare and Health, Helsinki, Finland
    • Corresponding Author InformationReprint requests: Reija Klemetti, P.O. Box 220, 00531 Helsinki, Finland (FAX: 358-9-3967 2496).
    • ,
  • Tiina Sevón, M.Soc.Sc.

      Affiliations

    • Health Services Research, STAKES, National Research and Development Centre for Welfare and Health, Helsinki, Finland
    • ,
  • Mika Gissler, Dr.Phil.

      Affiliations

    • Information Unit, STAKES, National Research and Development Centre for Welfare and Health, Helsinki, Finland
    • ,
  • Elina Hemminki, Dr.PH.

      Affiliations

    • Health Services Research, STAKES, National Research and Development Centre for Welfare and Health, Helsinki, Finland

Received 7 May 2008 ,Revised 9 December 2008 ,Accepted 11 December 2008.

References 

  1. Fauser BC, Devroey P, Macklon NS. Multiple birth resulting from ovarian stimulation for subfertility treatment. [see comment] Lancet. 2005;365:1807–1816
  2. Gissler M. Hedelmällisyys suomessa ennen, nyt ja tulevaisuudessa [Fertility in Finland in the past, present and future]. Yhteiskuntapolitiikka. 2003;6:553–565
  3. Nyboe Andersen A, Erb K. Register data on assisted reproductive technology (ART) in Europe including a detailed description of ART in denmark. Int J Androl. 2006;29:12–16
  4. Addor V, Santos-Eggimann B, Fawer CL, Paccaud F, Calame A. Impact of infertility treatments on the health of newborns. Fertil Steril. 1998;69:210–215
  5. Källén B, Olausson PO, Nygren KG. Neonatal outcome in pregnancies from ovarian stimulation. Obstet Gynecol. 2002;100:414–419
  6. Wang JX, Norman RJ, Kristiansson P. The effect of various infertility treatments on the risk of preterm birth. Hum Reprod. 2002;17:945–949
  7. Gaudoin M, Dobbie R, Finlayson A, Chalmers J, Cameron IT, Fleming R. Ovulation induction/intrauterine insemination in infertile couples is associated with low-birth-weight infants. Am J Obstet Gynecol. 2003;188:611–616
  8. Ombelet W, Martens G, De Sutter P, Gerris J, Bosmans E, Ruyssinck G, et al. Perinatal outcome of 12,021 singleton and 3108 twin births after non-IVF-assisted reproduction: a cohort study. Hum Reprod. 2006;21:1025–1032
  9. Verstraelen H, Goetgeluk S, Derom C, Vansteelandt S, Derom R, Goetghebeur E, et al. Preterm birth in twins after subfertility treatment: Population based cohort study. BMJ. 2005;331:1173
  10. Olson CK, Keppler-Noreuil KM, Romitti PA, Budelier WT, Ryan G, Sparks AE, et al. In vitro fertilization is associated with an increase in major birth defects. Fertil Steril. 2005;84:1308–1315
  11. Tulandi T, Martin J, Al-Fadhli R, Kabli N, Forman R, Hitkari J, et al. Congenital malformations among 911 newborns conceived after infertility treatment with letrozole or clomiphene citrate. Fertil Steril. 2006;85:1761–1765
  12. Klemetti R, Gissler M, Sevon T, Koivurova S, Ritvanen A, Hemminki E. Children born after assisted fertilization have an increased rate of major congenital anomalies. Fertil Steril. 2005;84:1300–1307
  13. Zhu JL, Basso O, Obel C, Bille C, Olsen J. Infertility, infertility treatment, and congenital malformations: Danish national birth cohort. BMJ. 2006;333:679
  14. Hemminki E, Klemetti R, Rinta-Paavola M, Martikainen J. Identifying exposures of in vitro fertilization from drug reimbursement files: a case study from Finland. Med Inform Internet Med. 2003;28:279–289
  15. Gissler M, Klemetti R, Sevon T, Hemminki E. Monitoring of IVF birth outcomes in Finland: a data quality study. BMC Med Inf Decis Mak. 2004;4:3
  16. Klemetti R, Sevon T, Gissler M, Hemminki E. Health of children born as a result of in vitro fertilization. Pediatrics. 2006;118:1819–1827
  17. Gissler M, Teperi J, Hemminki E, Merilainen J. Data quality after restructuring a national medical registry. Scand J Soc Med. 1995;23:75–80
  18. Teperi J. Multi method approach to the assessment of data quality in the finnish medical birth registry. J Epidemiol Community Health. 1993;47:242–247
  19. Keskimaki I, Aro S. Accuracy and data on diagnoses, procedures and accidents in the finnish hospital discharge register. Int J Health Sci. 1991;2:15–21
  20. Pinborg A, Lidegaard O, la Cour Freiesleben N, Andersen AN. Consequences of vanishing twins in IVF/ICSI pregnancies. Hum Reprod. 2005;20:2821–2829
  21. Smith GCS, Stenhouse EJ, Crossley JA, Aitken DA, Cameron AD, Connor JM. Early pregnancy levels of pregnancy-associated plasma protein A and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirth. J Clin Endocrinol Metab. 2002;87:1762–1767
  22. Dugoff L, Hobbins JC, Malone FD, Porter TF, Luthy D, Comstock CH, et al. First-trimester maternal serum PAPP-A and free-beta subunit human chorionic gonadotrophin concentrations and nuchal translucency are associated with obstetric complications: A population-based screening study (The FASTER Trial). Am J Obstet Gynecol. 2004;191:1446–1451
  23. Basso O, Baird DD. Infertility and preterm delivery, birthweight, and caesarean section: a study within the Danish national birth cohort. Hum Reprod. 2003;18:2478–2484
  24. Källén B, Finnström O, Nygren KG, Otterblad-Olausson P. In vitro fertilization in Sweden: child morbidity including cancer risk. Fertil Steril. 2005;84:605–610
  25. Venn A, Lumley J. Clomiphene citrate and pregnancy outcome. Aust N Z J Obstet Gynaecol. 1994;34:56–66
  26. Nuojua-Huttunen S, Gissler M, Martikainen H, Tuomivaara L. Obstetric and perinatal outcome of pregnancies after intrauterine insemination. Hum Reprod. 1999;14:2110–2115
  27. De Geyter C, De Geyter M, Steimann S, Zhang H, Holzgreve W. Comparative birth weights of singletons born after assisted reproduction and natural conception in previously infertile women. Hum Reprod. 2006;21:705–712

 R.K. has nothing to disclose. T.S. has nothing to disclose. M.G. has nothing to disclose. E.H. has nothing to disclose.

 Supported by the Academy of Finland (number 73159), the Social Insurance Institution, the Ministry of Education (The School of Doctoral Programs in Public Health), and the National Research and Development Centre for Welfare and Health.

PII: S0015-0282(08)04729-8

doi: 10.1016/j.fertnstert.2008.12.025

Fertility and Sterility
Volume 93, Issue 4 , Pages 1157-1168 , 1 March 2010

Article Tools