Fertility and Sterility
Volume 93, Issue 6 , Pages 1831-1836 , April 2010

Effect of polychlorinated biphenyls (PCBs) and 1,1,1-trichloro-2,2,-bis (4-chlorophenyl)-ethane (DDT) in follicular fluid on the results of in vitro fertilization–embryo transfer (IVF-ET) programs

  • Simona Jirsová, M.D.

      Affiliations

    • Department of Gynecology and Obstetrics, Charles University, First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic
    • Corresponding Author InformationReprint requests: Dr. Simon Jirsová, Department of Gynecology and Obstetrics, First Faculty of Medicine, Charles University, Apolinářská 18, 128 51 Prague, Czech Republic (FAX: +420 224 922 545).
  • ,
  • Jaromír Mašata, M.D., Ph.D.

      Affiliations

    • Department of Gynecology and Obstetrics, Charles University, First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic
  • ,
  • Libor Jech, R.N.Dr.

      Affiliations

    • AXYS Varilab, Vrané nad Vltavou, Czech Republic
  • ,
  • Jana Zvárová, Prof., R.N.Dr., Ph.D., D.Sc.

      Affiliations

    • EuroMISE Centrum of Charles University and Academy of Science of the Czech Republic, Institute of Computer Science AS CR, Prague, Czech Republic

Received 12 September 2008 ,Revised 13 December 2008 ,Accepted 16 December 2008.

References 

  1. Rivas A, Fernándes MF, Cerrillo I, Ibarluzea J, Olea-Serrano MF, Pedraza V, et al. Human exposure to endocrine disrupters: standardisation of a marker of estrogenic exposure in adipose tissue. APMIS. 2001;109:189–197
  2. Fernández MF, Olmos B, Granada A, Lopez MJ, Lopez C, Canos A, et al. Organochlorine determination in human placentas from different regions. Organohalogen Compd. 2002;58:301–304
  3. Cerna M, Bajgar L, Crhova S, Grabic R, Kozak J, Kratenova J, et al. Levels of PCDDs, PCDFs, and PCBs in the blood of the nonoccupationally exposed residents living in the vicinity of chemical plant, comparison with a background level for the Czech population. Organohalogen Compd. 2004;66:2667–2671
  4. Giullette LJ, Gross TS, Masson GR, Matter JM. Developmental abnormalities of the gonad and abnormal sex hormone concentration in juvenile alligators from contaminated and control lakes in Florida. Environ Health Persp. 1994;102:680–688
  5. Participating Organizations of the International POPs Elimination Network. Stockholm Convention on Persistent Organic Pollutants for adoption by the Conference of Plenipotentiaries. The POPs Handbook for the Stockholm Convention on Persistent Organic Pollutants. United Nations, 2001:35.
  6. Sakkas D. Evaluation of embryo quality: a strategy for sequential analysis of embryo development with aim of single embryo transfer. In:  Gardner DK,  Weissman A,  Howles CM,  Shoham Z editor. Textbook of assisted reproductive techniques. London: Martin Dunitz; 2001;p. 223–232
  7. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc B. 1995;57:289–300
  8. Gentleman R, Ithaka R. Project of the Statistics Department of the University of Auckland. 1997. Available at: http://www.r-project.org/. Last accessed 10 August 2008.
  9. Drbohlav P, Bencko V, Masata J, Rezacova J, Zouhar T, Cerný V, et al. Detection of cadmium and zinc in follicular fluid of women undergoing IVF + ET program. Czech Gynek. 1998;63:301–305
  10. Bonefeld-Jorgensen EC, Andersen HR, Rasmussen TH, Vinggaard AM. Effect of highly bioaccumulated polychlorinated biphenyl congeners on estrogen and androgen receptor activity. Toxicology. 2001;158:141–153
  11. Kelce WR, Gray LE, Wilson EM. Antiandrogens as environmental endocrine disruptors. Reprod Fertil Dev. 1998;10:105–111
  12. Schrader TJ, Cooke GM. Effects of aroclors and individual PCB congeners on activation of the human androgen receptor in vitro. Reprod Toxicol. 2003;17:15–23
  13. Scippo ML, Argiris C, Van De Weerdt C, Muller M, Willemsen P, Martial J, et al. Recombinant human estrogen, androgen and progesterone receptors for detection of potential endocrine disruptors. Anal Bioanal Chem. 2004;378:664–669
  14. Matsui M, Kashima Y, Kawano M, Matsuda M, Wakimoto T, Doi R. Estrogenicity in crude and fractionated extracts of medical waste incinerator ashes. Organohalogen Compd. 2001;56:61–64
  15. Mukerjee D. Endocrine disrupting chemicals and their association with male sexual abnormalities. Organohalogen Compd. 2003;60–5:269–280
  16. Langer P, Kocan A, Tajtakova M, Petrik J, Chovancova J, Drobna B, et al. Possible effects of polychlorinated biphenyls and organochlorinated pesticide on the thyroid after long-term exposure to heavy environmental pollution. J Occup Environ Med. 2003;45:526–532
  17. Takasuga T, Senthilkumar K, Watanabe K, Takemori H, Shoda T, Kuroda Y. Ultratrace analysis of polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs) in human serum and cerebrospinal fluid (CSF) samples. Organohalogen Compd. 2004;66:2530–2533
  18. Birnbaum LS, Fenton S. Role of developmental exposure to endocrine disruptors in cancer. Organohalogen Compd. 2002;56:65–69
  19. Gaisina AF, Kaioumova FF. Erythron respone to PCB intoxication. Organohalogen Compd. 2002;55:489–493
  20. Wu Y, Younglai EW. Rapid effects of pesticides on intracellular calcium changes in human granulosa-lutein cells. Fertil Steril. 2005;84:433
  21. Younglai EV, Kwan TK, Kwan CY, Lobb DK, Foster WG. Dichlorodiphenylchloroethylen elevates cytosolic kalcium concentrations and oscillations in primary cultures of human granulosalutien cells. Biol Reprod. 2004;70:1693–1700
  22. Rignell-Hydbom A, Rylander L, Giwercman A, Jönsson A, Lindh C, Eleuteri P, et al. Exposure to PCBs and p,p′-DDE and human sperm chromatin integrity. Environ Health Perspect. 2005;113:175–179
  23. Rignell-Hydbom A, Rylander L, Giwercman A, Jönsson A, Lindh C, Eleuteri P, et al. Serum levels of 2,2′,4,4′,5,5′- hexachlorbiphenyl in relation to semen quality and quantity among Swedish fishermen. Organohalogen Compd. 2003;60:2865–2869
  24. Spano M, Toft G, Hagmar L, Eleuteri P, Rescia M, Rignell-Hydbom A, et al. Exposure to PCB and p,p′-DDE in European and Inuit populations: impact on human sperm chromatin integrity. Hum Reprod. 2005;20:3488–3499
  25. Pflieger-Bruss P, Schill WB. Effects of chlorinated hydrocarbons on sperm function in vitro. Andrologia. 2000;32:311–315
  26. Cooper GS, Klebanoff MA, Promislow J, Brock JW, Longnecker MP. Polychlorinated biphenyls and menstrual cycle characteristics. Epidemiology. 2005;16:191–200
  27. Ouyang F, Perry MJ, Venners SA, Chen C, Wang B, Yang F, et al. Serum DDT, age at menarche, and abnormal menstrual cycle length. Occup Environ Med. 2005;62:878–884
  28. Perry MJ, Ouyang F, Korrick SA, Venners SA, Chen C, Xu X, et al. A prospective study of serum DDT and progesterone and estrogen levels across the menstrual cycle in nulliparous women of reproductive age. Am J Epidemiol. 2006;164:1056–1064
  29. Windham GC, Lee D, Mitchell P, Anderson M, Petreas M, Lasley B. Exposure to organochlorine compounds and effects on ovarian function. Epidemiology. 2005;16:182–190
  30. Toft G, Axmon A, Lindh CH, Giwercman A, Bonde JP. Menstrual cycle characteristics in European and Inuit women exposed to persistent organochlorine pollutants. Hum Reprod. 2008;23:193–200
  31. Schaefer WR, Hermann T, Meinhold-Heerlein I, Deppert WR, Zahradnik HP. Exposure of human endometrium to environmental estrogens, antiandrogens, and organochlorine compounds. Fertil Steril. 2000;74:558–563
  32. Shen H, Main KM, Andersson A, Damgaard IN, Virtanen HE, Skakkebaek NE, et al. Concentrations of persistent organochlorine compounds in human milk and placenta are higher in Denmark than in Finland. Hum Reprod. 2008;23:201–210
  33. Olea N. The combined effect of environmental hormones and the risk of hormone dependent diseases. Organohalogen Compd. 2002;59:1–4
  34. La Rocca C, Abate V, Alivernini S. Levels of PCBs, DDT, DDE and DDD in Italian human blood samples. Organohalogen Compd. 2004;66:2789–2793
  35. Pauwels A, Schepens PJC, Hooghe TD, Delbeke L, Dhout M, Brouwer A, et al. The risk of endometriosis and exposure to dioxins and polychlorinated biphenyls: a case-control study of infertile women. Hum Reprod. 2001;6:2050–2055
  36. Foster W, Chan S, Platt L, Hughes C. Detection of endocrine disrupting chemicals in samples of second trimester human amniotic fluid. J Clin Endocrinol Metab. 2000;85:2954–2957
  37. Sala M, Ribas-Fito N, Cardo E, De Muga ME, Marco E, Mazon C, et al. Levels of hexachlorobenzene and other organochlorine compounds in cord blood: exposure across placenta. Chemosphere. 2001;43:895–901
  38. Waliszewski SM, Aguirre AA, Infanzon RM, Siliceo J. Carry-over of persistent organochlorine pesticides through placenta to fetus. Salud Publica Mex. 2000;42:384–390
  39. Mašata J, Jirsová S, Drbohlav P, Jech L, Bencko V, Omelka M, et al. Comparation of organochlorine pesticide levels in blood and follicular fluid of infertile women. Czech Gynek. 2005;70:440–446

 S.J. has nothing to disclose. J.M. has nothing to disclose. L.J. has nothing to disclose. J.Z. has nothing to disclose.

 Supported by the Internal Grant Agency of Ministry of Health of the Czech Republic.

PII: S0015-0282(08)04782-1

doi: 10.1016/j.fertnstert.2008.12.063

Fertility and Sterility
Volume 93, Issue 6 , Pages 1831-1836 , April 2010