Fertility and Sterility
Volume 93, Issue 7 , Pages 2295-2298, 1 May 2010

Effects of testosterone and metformin on glucose metabolism in endometrium

  • Lei Zhang, M.D.

      Affiliations

    • Reproductive and Genetic Center, The First Hospital of Peking University, Beijing, People's Republic of China
    • Corresponding Author InformationReprint requests: Lei Zhang (FAX: 086-010-66551216).
    • ,
  • Qinping Liao, M.D.

      Affiliations

    • Obstetrics and Gynecology, The First Hospital of Peking University, Beijing, People's Republic of China

Received 25 May 2008; received in revised form 19 January 2009; accepted 19 January 2009. published online 27 March 2009.

Objective

To investigate the effects of testosterone and metformin on glucose metabolism in endometrium.

Design

In vitro experiment.

Setting

Reproductive and Genetic Center, Obstetrics and Gynecology, The First Hospital of Peking University, Beijing, China.

Patient(s)

Premenopausal women undergoing total abdominal hysterectomy for uterine myoma or adenomyosis.

Intervention(s)

Endometrial glandular epithelial cell culture.

Main Outcome Measure(s)

Insulin receptor substrate-1 (IRS-1) and glucose transporter 4 (GLUT-4) expression in endometrial glandular epithelial cell.

Result(s)

After the action of testosterone solution, the protein expressions of IRS-1mRNA, IRS-1, and GLUT-4 in endometrial glandular epithelial cells all decreased significantly. Metformin may reverse this effect.

Conclusion(s)

The high androgen levels in patients with polycystic ovary syndrome could induce insulin resistance in endometrial glandular epithelial cell, whereas metformin has an antagonizing effect.

Key Words: PCOS, metformin, endometrium, IRS-1, GLUT-4

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 L.Z. has nothing to disclose. Q.L. has nothing to disclose.

PII: S0015-0282(09)00155-1

doi:10.1016/j.fertnstert.2009.01.096

Fertility and Sterility
Volume 93, Issue 7 , Pages 2295-2298, 1 May 2010

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