Fertility and Sterility
Volume 93, Issue 7 , Pages 2295-2298 , 1 May 2010

Effects of testosterone and metformin on glucose metabolism in endometrium

  • Lei Zhang, M.D.

      Affiliations

    • Reproductive and Genetic Center, The First Hospital of Peking University, Beijing, People's Republic of China
    • Corresponding Author InformationReprint requests: Lei Zhang (FAX: 086-010-66551216).
    • ,
  • Qinping Liao, M.D.

      Affiliations

    • Obstetrics and Gynecology, The First Hospital of Peking University, Beijing, People's Republic of China

Received 25 May 2008 ,Revised 19 January 2009 ,Accepted 19 January 2009.

References 

  1. Mertens H, Heineman M, Theunissen P, De Jong F, Evers J. Androgen, estrogen and progesterone receptor expression in the human uterus during the menstrual cycle. Eur J Obstet Gynecol Reprod Biol. 2001;98:58–65
  2. Chen Xin, Li X, Huang Haiyan, Li X, Lin JF. Effects of testosterone on insulin receptor substrate-1 and glucose transporter 4 expression in cells sensitive to insulin. Zhonghua Yi Xue Za Zhi. 2006;86:1474–1477
  3. Wu XK, Sallinen K, Anttila L, Mäkinen M, Luo C, Pöllänen P, et al. Expression of insulin-receptor substrate-1 and 2 in anries from women with insulin resistance and from controls. Fertil Steril. 2000;74:564–572
  4. Randolph JF, Kipersztok S, Ayers JWT, Ansbacher R, Peegel H, Menon KM. The effect of insulin on aromatase activity in isolated human endometrial glands and stroma. Am J Obestet Gynecol. 1987;157:1534–1539
  5. Waterworth DM, Bennett ST, Gharani N, McCarthy MI, Hague S, Batty S, et al. Linkage and association of insulin gene VN-IR regulatory polymorphism with polycystic ovary syndrome. Lancet. 1997;349:986–990
  6. Palomba S, Russo T, Orio F, Falbo A, Manguso F, Cascella T, et al. Uterine effects of metformin administration in anovulatory women with polycystic ovary syndrome. Hum Reprod. 2006;21:457–465
  7. Aebay O, Gmdoydu S. Can metformin reduce insulin resistance in polycystic ovary syndrome. Fertil Steril. 1996;65:946–949
  8. Jakubowicz DJ, Seppälä M, Jakubowicz S, Rodriguez-Armas O, Rivas-Santiago A, Koistinen H, et al. Insulin reduction with metformin increases luteal phase serum glycodelin and insulin-like growth factor-binding protein 1 concentrations and enhances uterine vascularity and blood flow in the polycystic ovary syndrome. J Clin Endocrinol Metab. 2001;86:1126–1133
  9. Chou KH, Von-Eye-Corleta H, Capp E, Spritzer PM, et al. Clinical, metabolic and endocrine parameters in response to metformin in obese women with polycystic ovary syndrome: a randomized, double-blind and placebo-controlled trial. Horm Metab Res. 2003;35:86–91

 L.Z. has nothing to disclose. Q.L. has nothing to disclose.

PII: S0015-0282(09)00155-1

doi: 10.1016/j.fertnstert.2009.01.096

Fertility and Sterility
Volume 93, Issue 7 , Pages 2295-2298 , 1 May 2010

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