Fertility and Sterility
Volume 93, Issue 2 , Pages 527-536 , 15 January 2010

Direct health services costs of providing assisted reproduction services in older women

Presented at British Fertility Society Summer College, September 4, 2008, Liverpool, U.K.

  • Abha Maheshwari, M.R.C.O.G.

      Affiliations

    • Department of Obstetrics and Gynaecology, University of Aberdeen, Aberdeen Maternity Hospital, Aberdeen, Scotland
    • Corresponding Author InformationReprint requests: Abha Maheshwari, Clinical Lecturer and Subspeciality Trainee in Reproductive Medicine, University Department of Obstetrics and Gynaecology, Aberdeen Maternity Hospital, Foresterhill, Aberdeen, AB25 2ZL, U.K. (FAX: + 44 1224 551072).
    • ,
  • Graham Scotland, M.Sc.

      Affiliations

    • Health Economics Research Unit, University of Aberdeen, Aberdeen Maternity Hospital, Aberdeen, Scotland
    • ,
  • Jacqueline Bell, M.Sc.

      Affiliations

    • Department of Public Health, University of Aberdeen, Aberdeen Maternity Hospital, Aberdeen, Scotland
    • ,
  • Alison McTavish, R.G.C.R.N.

      Affiliations

    • Department of Obstetrics and Gynaecology, University of Aberdeen, Aberdeen Maternity Hospital, Aberdeen, Scotland
    • ,
  • Mark Hamilton, M.D.

      Affiliations

    • Department of Obstetrics and Gynaecology, University of Aberdeen, Aberdeen Maternity Hospital, Aberdeen, Scotland
    • ,
  • Siladitya Bhattacharya, M.D.

      Affiliations

    • Department of Obstetrics and Gynaecology, University of Aberdeen, Aberdeen Maternity Hospital, Aberdeen, Scotland

Received 14 November 2008 ,Revised 16 January 2009 ,Accepted 19 January 2009.

References 

  1. te Velde ER, Pearson PL. The variability of female reproductive ageing. Hum Reprod Update. 2002;8:141–154
  2. Templeton A, Morris J, Parslow W. Factors that affect outcome of in-vitro fertilization treatment. Lancet. 1996;348:1402–1406
  3. Baird DT, Collins J, Egozcue J, Evers LH, Gianaroli L, Leridon H, et al. ESHRE Capri Workshop Fertility and ageing. Hum Reprod Update. 2005;11:261–276
  4. Tough SC, Newburn-Cook C, Johnston DW, Svenson LW, Rose S, Belik J. Delayed childbearing and its impact on population rate changes in lower birth weight, multiple birth, and preterm delivery. Pediatrics. 2002;109:399–403
  5. Bell JS, Campbell DM, Graham WJ, Penny GC, Ryan M, Hall MH. Can obstetric complications explain the high levels of obstetric interventions and maternity service use among older women? A retrospective analysis of routinely collected data. BJOG. 2001;108:910–918
  6. Hecht CA, Hook EB. Rates of Down syndrome at live birth by one-year maternal age intervals in studies with apparent close to complete ascertainment in populations of European origin: a proposed revised rate schedule for use in genetic and prenatal screening. Am J Med Genet. 1996;62:376–385
  7. Temmerman M, Verstraelen H, Martens G, Bekaert A. Delayed childbearing and maternal mortality. Euro J Obstet Gynecol Reprod Biol. 2004;114:19–22
  8. Alonzo AA. Long-term health consequences of delayed childbirth: NHANES III. Womens Health Issues. 2002;12:37–45
  9. Cleary-Goldman J, Malone FD, Vidaver J, Ball RH, Nyberg DA, Comstock CH, et al. FASTER Consortium Impact of maternal age on obstetric outcome. Obstet Gynecol. 2005;105:983–990
  10. Collins J, Feeny D, Gunby J. The cost of infertility diagnosis and treatment in Canada in 1995. Hum Reprod. 1997;12:951–958
  11. Mol BW, Bonsel GJ, Collins JA, Wiegerinck MA, van der Veen F, Bossuyt PM. Cost-effectiveness of in-vitro fertilization and embryo transfer. Fertil Steril. 2000;73:748–754
  12. Philips Z, Barraza-Llorens M, Posnett J. Evaluation of the relative cost-effectiveness of treatments for infertility in UK. Hum Reprod. 2000;15:95–106
  13. Bouwmans CAM, Lintsen BMEA, Eijkemans MJC, Habbema JDF, Bratt DDM, Hakkaart L. A detailed cost analysis of in vitro fertilization and intracytoplasmic sperm injection treatment. Fertil Steril. 2008;89:331–341
  14. National Institute of Clinical Excellence Fertility—assessment and treatment for people with fertility problems. Clinical Guideline no. 11, NICE UK. London: National Collaborating Centre for Women's and Children's Health; 2004;
  15. Chambers GM, Ho MT, Sullivan EA. Assisted reproductive-technology treatment costs of a live-birth: an age stratified cost-outcome study of treatment in Australia. Med J Aust. 2006;184:155–18
  16. Bhattacharya S, Campbell DM. The incidence of severe complications of pre-eclampsia. Hypertens Pregnancy. 2005;24:181–190
  17. Maheshwari A, Hamilton M, Bhattacharya S. Effect of female age on the diagnostic categories of infertility. Hum Reprod. 2008;23:538–542
  18. Maheshwari A, Bhattacharya S, Daya S, Gibreel A, Siristatidis CS. Gonadotrophin-releasing hormone agonist protocols for pituitary down regulation in assisted reproductive treatment (protocol). Cochrane Database Syst Rev. 2008;(2):
  19. Mathur R, Evbuomwan I, Jenkins J. Prevention and management of ovarian hyperstimulauion syndrome. Currt Obstet Gynecol. 2005;15:132–138
  20. Briggs AH, O'Brien BJ, Blackhouse G. Thinking outside the box: recent advances in the analysis and presentation of uncertainty in cost-effectiveness studies. Annu Rev Public Health. 2002;23:377–401
  21. Sykes D, Out H, Palmer S, van Loon J. The cost effectiveness of IVF in the UK: A comparison of three gonadotrophin treatments. Hum Reprod. 2001;16:2557–2562
  22. Daya S, Ledger W, Auray J, Duru G, Silverberg K, Wikland M, et al. Cost effectiveness modelling of recombinanat FSH versus urinary FSH in assisted reproduction techniques in the UK. Hum Reprod. 2001;16:2563–2569
  23. Malizia BA, Hacker MR, Penzias AS. Cumulative live-birth rates after in-vitro fertilization. N Engl J Med. 2009;360:236–243
  24. Andersen AN, Goossens V, Ferraretti AP, Bhattacharya S, Felberbaum R, de Mouzon J, et al. European IVF-Monitoring (EIM) Consortium, European Society of Human Reproduction and Embryology (ESHRE) Assisted reproductive technology in Europe, 2004: results generated from European registers by ESHRE. Hum Reprod. 2008;23:756–771
  25. Schartwatnachai C, Wongkularb A, Srisombut C, Chokanasiri W, Chinsomboon S, Rojanasakul A. Cost-effectiveness of IVF in women 38 years and older. Int J Gynecol Obstet. 2000;69:143–148
  26. Ledger W, Anumba D, Marlow N, Thomas C, Wilson E Cost of Multiple Births Study Group (COMBS Group). The costs to the NHS of multiple births after IVF treatment in the UK. BJOG. 2006;113:21–25
  27. Dixon S, Nasiri FF, Ledger W, Lenton EA, Duenas A, Sutcliffe P, et al. Cost-effectiveness analysis of different embryo transfer strtegies in England. BJOG. 2008;115:758–766
  28. McManus J, Traub A. The impact of an assisted conception unit on the workload of a general gynaecology unit. BJOG. 2002;109:207–211
  29. Henderson J, McCandlish R, Kumiega L, Petrou S. Systematic review of economic aspects of alternative modes of delivery. BJOG. 2001;108:149–157
  30. Garceau L, Henderson J, Davis L, Petrou S, Henderson L, McVeigh E, et al. Economic implications of assisted reproductive techniques: a systematic review. Hum Reprod. 2002;17:3090–3109
  31. Maheshwari A, Hamilton M, Bhattacharya S. A survey of clinicians' views on the effect of age on access to in-vitro fertilization (IVF) and the use of tests of ovarian reserve prior to IVF in the United Kingdom. Hum Fertil. 2008;11:23–27

 A.M. has nothing to disclose. G.S. has nothing to disclose. J.B. has nothing to disclose. A.M. has nothing to disclose. M.H. has nothing to disclose. S.B. has nothing to disclose.

 Supported by National Health Service Endownment (07/63) and the University of Aberdeen.

PII: S0015-0282(09)00238-6

doi: 10.1016/j.fertnstert.2009.01.115

Fertility and Sterility
Volume 93, Issue 2 , Pages 527-536 , 15 January 2010

Article Tools

* Image Usage & Resolution