Intrauterine insemination with or without mild ovarian stimulation in couples with male subfertility due to oligo/astheno- and/or teratozoospermia or antisperm antibodies: a prospective cross-over trial
Received 23 September 2008; received in revised form 13 January 2009; accepted 19 January 2009. published online 03 March 2009.
Seventy-three couples with male subfertility, which was due to oligo/astheno- and/or teratozoospermia (n = 63) or antisperm antibodies (n = 10), were randomly assigned to sequential timed natural intercourse, intrauterine insemination (IUI) and IUI + mild ovarian hyperstimulation. From the analysis of 384 observed cycles, IUI was shown to be effective in oligo/asthenozoospermia without severe teratozoospermia, when it was associated with moderate multifollicular induction, and in male immunologic subfertility, IUI was highly effective in nonstimulated cycles also.
aAndrologic Unit, Department of Internal Medicine, University of L'Aquila, L'Aquila, Italy
bEpidemiology, Department of Internal Medicine, University of L'Aquila, L'Aquila, Italy
Reprint requests: Prof. Felice Francavilla, M.D., Department of Internal Medicine, University of L'Aquila, Blocco 11, Coppito, 67100, Coppito, L'Aquila, Italy (FAX: +39 0862 368342).
F.F. has nothing to disclose. F.S. has nothing to disclose. S.S. has nothing to disclose. S.N. has nothing to disclose. R.S. has nothing to disclose. A.B. has nothing to disclose. S.F. has nothing to disclose.
ABSTRACT