Fertility and Sterility
Volume 93, Issue 5 , Pages 1388-1393 , 15 March 2010

Preventive role of exogenous testosterone on cisplatin-induced gonadal toxicity: an experimental placebo-controlled prospective trial

Presented at the XI Congress of Iranian Urological Association, Tehran, Iran, May 29–June 1, 2008.

  • Alireza Aminsharifi, M.D.

      Affiliations

    • Department of Urology, Comparative Medicine Research Center, Shiraz Nephrology Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
    • Corresponding Author InformationReprint requests: Alireza Aminsharifi, M.D., Department of Urology, Faghihi Hospital, Zand Boulevard, Shiraz, I.R. Iran (FAX: 98-711-2330-724).
    • ,
  • Saeed Shakeri, M.D.

      Affiliations

    • Department of Urology, Comparative Medicine Research Center, Shiraz Nephrology Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
    • ,
  • Ali Ariafar, M.D.

      Affiliations

    • Department of Urology, Comparative Medicine Research Center, Shiraz Nephrology Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
    • ,
  • Behnam Moeinjahromi

      Affiliations

    • Department of Urology, Comparative Medicine Research Center, Shiraz Nephrology Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
    • ,
  • Prikala V. Kumar, M.D.

      Affiliations

    • Department of Pathology, Comparative Medicine Research Center, Shiraz Nephrology Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
    • ,
  • Saeed Karbalaeedoost, M.Sc.

      Affiliations

    • Department of Anatomy, Comparative Medicine Research Center, Shiraz Nephrology Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Received 5 January 2009 ,Revised 3 February 2009 ,Accepted 6 February 2009.

References 

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  14. Glode LM, Robinson J, Gould SF. Protection from cyclophosphamide-induced testicular damage with an analogue of gonadotropin-releasing hormone. Lancet. 1981;1:1132–1134
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  16. Delic JI, Bush C, Peckham MJ. Protection from procarbazine-induced damage of spermatogenesis in the rat by androgen. Cancer Res. 1986;46:1909–1914
  17. Meistrich ML, Wilson G, Kangasniemi M, Huhtaniemi I. Mechanism of protection of rat spermatogenesis by hormonal pretreatment: stimulation of spermatogonal differentiation after irradiation. J Androl. 2000;21:464–469
  18. Udagawa K, Ogawa T, Watanabe T, Tamura Y, Kita K, Kubota Y. Testosterone administration promotes regeneration of chemically impaired spermatogenesis in rats. Int J Urol. 2006;13:1103–1108
  19. Meistrich ML, Wilson G, Porter KL, Huhtaniemi I, Shetty G, Shuttlesworth GA. Restoration of spermatogenesis in dibromochloropropane (DBCP)-treated rats by hormone suppression. Toxicol Sci. 2003;76:418–426
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 A.A. has nothing to disclose. S.S. has nothing to disclose. A.Ar. has nothing to disclose. B.M. has nothing to disclose. P.V.K. has nothing to disclose. S.K. has nothing to disclose.

 Supported by the Shiraz University of Medical Sciences, Shiraz, Iran.

PII: S0015-0282(09)00369-0

doi: 10.1016/j.fertnstert.2009.02.028

Fertility and Sterility
Volume 93, Issue 5 , Pages 1388-1393 , 15 March 2010

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