Fertility and Sterility
Volume 94, Issue 1 , Pages 144-148 , June 2010

Poor success of gonadotropin-induced controlled ovarian hyperstimulation and intrauterine insemination for older women

  • Isiah D. Harris, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
    • ,
  • Stacey A. Missmer, Sc.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
    • Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
    • Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
    • ,
  • Mark D. Hornstein, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
    • Corresponding Author InformationReprint requests: Dr. Mark D. Hornstein, 75 Francis Street, Boston, MA 02115 (FAX: 617-566-7752).

Received 28 August 2008 ,Revised 12 February 2009 ,Accepted 12 February 2009.

References 

  1. Melis GB, Paoletti AM, Ajossa S, Guerriero S, Depau GF, Mais V. Ovulation induction with gonadotropins as sole treatment in infertile couples with open tubes: a randomized prospective comparison between intrauterine insemination and timed vaginal intercourse. Fertil Steril. 1995;64:1088–1093
  2. Vlahos NF, Coker L, Lawler C, Zhao Y, Bankowski B, Wallach EE. Women with ovulatory dysfunction undergoing ovarian stimulation with clomiphene citrate for intrauterine insemination may benefit from administration of human chorionic gonadotropin. Fertil Steril. 2005;83:1510–1516
  3. Dodson WC, Haney AF. Controlled ovarian hyperstimulation and intrauterine insemination for treatment of infertility. Fertil Steril. 1991;55:457–467
  4. Martinez AR, Bernardus RE, Vermeiden JP, Schoemaker J. Basic questions on intrauterine insemination: an update. Obstet Gynecol Surv. 1993;48:811–828
  5. Deaton JL, Gibson M, Blackmer KM, Nakajima ST, Badger GJ, Brumsted JR. A randomized, controlled trial of clomiphene citrate and intrauterine insemination in couples with unexplained infertility or surgically corrected endometriosis. Fertil Steril. 1990;54:1083–1088
  6. Hughes EG. Stimulated intra-uterine insemination is not a natural choice for the treatment of unexplained subfertility. ”Effective treatment” or “not a natural choice”?. Hum Reprod. 2003;18:912–914
  7. Dankert T, Kremer JA, Cohlen BJ, Hamilton CJ, Pasker-de Jong PC, Straatman H, et al. A randomized clinical trial of clomiphene citrate versus low dose recombinant FSH for ovarian hyperstimulation in intrauterine insemination cycles for unexplained and male subfertility. Hum Reprod. 2007;22:792–797
  8. Gregoriou O, Vlahos NF, Konidaris S, Papadias K, Botsis D, Creatsas GK. Randomized controlled trial comparing superovulation with letrozole versus recombinant follicle-stimulating hormone combined to intrauterine insemination for couples with unexplained infertility who had failed clomiphene citrate stimulation and intrauterine insemination. Fertil Steril. 2008;90:678–683
  9. Cantineau AE, Cohlen BJ, Heineman MJ. Ovarian stimulation protocols (antioestrogens, gonadotrophins with and without GnRH agonists/antagonists) for intrauterine insemination (IUI) in women with subfertility. Cochrane Database Syst Rev. 2007;(2):CD005356
  10. Gindoff PR, Jewelewicz R. Reproductive potential in the older woman. Fertil Steril. 1986;46:989–1001
  11. Jacobs SL, Metzger DA, Dodson WC, Haney AF. Effect of age on response to human menopausal gonadotropin stimulation. J Clin Endocrinol Metab. 1990;71:1525–1530
  12. Corsan G, Trias A, Trout S, Kemmann E. Ovulation induction combined with intrauterine insemination in women 40 years of age and older: is it worthwhile?. Hum Reprod. 1996;11:1109–1112
  13. Frederick JL, Denker MS, Rojas A, Horta I, Stone SC, Asch RH, et al. Is there a role for ovarian stimulation and intra-uterine insemination after age 40?. Hum Reprod. 1994;9:2284–2286
  14. Plosker SM, Jacobson W, Amato P. Predicting and optimizing success in an intra-uterine insemination programme. Hum Reprod. 1994;9:2014–2021
  15. Sahakyan M, Harlow BL, Hornstein MD. Influence of age, diagnosis, and cycle number on pregnancy rates with gonadotropin-induced controlled ovarian hyperstimulation and intrauterine insemination. Fertil Steril. 1999;72:500–504
  16. Goverde AJ, McDonnell J, Vermeiden JP, Schats R, Rutten FF, Schoemaker J. Intrauterine insemination or in-vitro fertilisation in idiopathic subfertility and male subfertility: a randomised trial and cost-effectiveness analysis. Lancet. 2000;355:13–18
  17. Van Voorhis BJ, Barnett M, Sparks AE, Syrop CH, Rosenthal G, Dawson J. Effect of the total motile sperm count on the efficacy and cost-effectiveness of intrauterine insemination and in vitro fertilization. Fertil Steril. 2001;75:661–668

 I.H. has nothing to disclose. S.M. has nothing to disclose. M.H. has nothing to disclose.

PII: S0015-0282(09)00430-0

doi: 10.1016/j.fertnstert.2009.02.040

Fertility and Sterility
Volume 94, Issue 1 , Pages 144-148 , June 2010

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